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Yingtian Pan, Ph.D.

Professor

Biophotonics Laboratory

Research Focus

Dr. Pan’s research focuses on developing innovative biophotonic imaging techniques. 3D cross-sectional imaging of biological tissue at close to cellular resolution (e.g., 2-10µm) and at depths of 1-3mm can have significant impacts on noninvasive clinical diagnosis of biological tissue abnormalities (e.g., early cancer detection, tracking engineering tissue growth and repair) and dysfunction (e.g., microischemia, paralysis). In Dr. Pan’s lab, several laser scanning catheter endoscopes, based on optical coherence tomography (OCT), laser Doppler flowmetry, and fluorescence imaging, have been developed and validated in vivo on a wide variety of biological tissues. Encouraging results based on preclinical and clinical studies show that the new-generation laser scanning endoscopes can provide morphological details correlated well with excisional histology, suggesting its potential for optical biopsy or optically guided biopsy to reduced negative biopsies in clinical practice. Current research of Dr. Pan’s lab is focused on subcellular-resolution imaging diagnosis of early cancers, interstitial cystitis, noninvasive longitudinal assessment of engineering tissue growth, functional neuroimaging, optogenetics, and drug addiction.

Dr. Pan and his group publish their findings in PNAS, J. of Clinical Investigation, Molecular Psychiatry, J. of Neuroscience, NeuroImage, Optics Letters, Applied Physics Letters, J. Urology, among others. Their work has been featured in Science Update, PBS NewsHour, Business Insider, Neuroscience News, BioPhotonics International, NIDA Front Page, SBU News, as well as cover pages of many peer-reviewed journals

Education

  • 1993 - 1996     Res. Fellow – Biophotonics, Medical Laser Center of Luebeck, Germany
  • 1992           Ph.D. - National Laser Technology Laboratories, China
  • 1988           M.Sc. - Huazhong University of Science and Technology, China
  • 1985           B.Sc. - Huazhong University of Science and Technology, China

Academic Appointments

  • 2008 - current: Professor, Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY
  • 2004 – 2008: Associate Professor, Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York
  • 2002 – 2004: Assistant Professor, Department of Biomedical Engineering, Stony Brook University, Stony Brook, New York
  • 2001 – 2002: Assistant Professor of Biomedical Engineering, McGowan Center for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA
  • 1999 – 2002: (Tenure Track) Assistant Professor of Medicine & Biomedical Engineering, University of Pittsburgh, and Principal Investigator, Science & Technology Center, Carnegie Mellon University, Pittsburgh, PA
  • 1996 – 1999: Sr. Imaging Scientist and Director of OCT Lab, (NSF) Center for Light Microscope Imaging & Biotechnology, Carnegie Mellon University, Pittsburgh, PA

PUBLICATIONS

Click here to search Yingtian Pan's Google Scholar listing.

PATENT APPLICATIONS

  • Y.T. Pan, C Du, H. Ren, N. Volkow, "Intralipid as a contrast agent to enhance subsurface blood flow imaging," US patent 61/670954 (07/12/2012)
  • Y.T. Pan, “An endoscopic optical biopsy device with subcellular resolutions,” US Patent 8948846, issued in 3/2015
  • Y.T. Pan, G. Fedder, H. Xie, P. Campbell, “An endoscopic laser scanning imaging device based on a MEMS micromirror,” US Patent 10/316,404, Publication 0142934 (2003)

 COURSES TAUGHT

  • BME 481 – Biosensors (SBU)
  • BME 502 – Numerical Methods in Biomedical Engineering (SBU)
  • BME 531 – Biosensing and Bioimaging (SBU)
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