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BME NEWS

October 2022

Graduate Program Highlights:

Communications Biology Paper for Yanzuo Liu 

ZoeyYanzuo (Zoey) Liu, a Ph.D. student in the Biomedical Engineering graduate program, recently published an article entitled “Cocaine’s cerebrovascular vasoconstriction is associated with
astrocytic Ca 2+ increase in mice” in the journal Communications Biology (a Nature publication with an impact factor of 6.3). Her research project emphasized to characterize the roles of neurons and astrocytes in mediating neurovascular coupling in the brain while its responses to a stimulant such as cocaine. In this study, it provided first time evidence of astrocyte’s involvement in the cocaine-induced vasoconstriction. Her experiments performed by using lab -developed multimodal imaging platform to simultaneously assess neuronal and astrocytic. activity and vascular hemodynamic changes in response to acute cocaine in the cortex of mice in vivo. The results showed that cocaine-evoked neuronal Ca activation inversely correlated with changes in tissue oxygenation, whereas a long-lasting increase in astrocytic Ca activity were associated with persistent vasoconstriction induced by cocaine. Also, inhibition of astrocyte activity prevented cocaine vasoconstriction. These findings indicate cellular and vascular interaction induced by cocaine which will be helpful for putative treatment strategies to reduce cerebrovascular pathology in brain diseases including cocaine use disorders.
This research was advised by Dr. Congwu Du in collaboration with Dr. Yingtian Pan and it was
supported by research grant from NIH. Co-authors including Yueming Hua and Kicheon Park
both are also graduate students at Stony Brook. For the details of this research, please check:

communications biologyLiu, Y., Hua, Y., Park, K. et al. Cocaine’s cerebrovascular vasoconstriction is associated with
astrocytic Ca 2+ increase in mice. Commun Biol 5, 936 (2022). https://doi.org/10.1038/s42003-
022-03877-w

Microsystems and Nanoengineering paper for Evan Lammertse 

evanEvan Lammertse, a 4 th year Ph.D. student in the BME graduate program, recently published an article entitled “Widely accessible method for 3D microflow mapping at high spatial and temporal resolutions” in the journal Microsystems & Nanoengineering (a Nature publication with an impact factor of 8). His research demonstrates the ability to track particles in microfluidic flows in 4D using open source and widely available equipment. In this report, Evan proved that we could use a simple brightfield microscopy to perform 3D particle tracing velocimetry to map microflows at high spatial and temporal resolution. He demonstrated that the 3D tracking of particles could be achieved by mapping the defocusing pattern to a library of calibrated patterns with a precision better than one micron. The paper illustrates the method by analyzing flow patterns of a single-phase flow, displacement structures, and microfluidic droplets. The method will prove fundamental in supporting the development and design of
novel microfluidic structures, and in addressing the increasing demand for controlling fluids at the micron scale.
The research was performed under the supervision of Dr. Brouzes. Co-authors include Dr. Martin Sauzade and Luc Anis who are a former post-doc and a BME undergraduate, respectively. The study was funded by the National Science Foundation.

evan research

Lammertse, E., Koditala, N., Sauzade, M. et al. Widely accessible method for 3D microflow mapping at high spatial and temporal resolutions. Microsyst Nanoeng 8, 72 (2022). https://doi.org/10.1038/s41378-
022-00404-z

September 2022

Snyders Scholars Program Recipient: Christopher Ashdown

ashdownChimeric antigen receptor T cell therapy, also known as CAR-T therapy, is a rapidly evolving immunotherapy that has the potential to revolutionize cancer treatment. Nevertheless, autologous CAR-T therapy remains a relatively inefficient process that is confounded by prohibitively long ex-vivo expansion periods and loss of effector function upon reintroduction to the patient. Thus, strategies which speed up the manufacturing process and help maintain T cell effector function would dramatically increase the speed and efficacy of CAR-T therapy.
Mammalian cells have well-conserved mechano-sensing and mechanoresponse mechanisms, the aggregate of which provide an important regulatory component for a variety of cellular responses. Our lab has spent decades developing Low-Intensity Vibration (LIV) as a mechanical regime modeled after the physiologic, high-frequency muscle contractions generated during exercise. We have previously found that in Mesenchymal Stem Cells (MSCs) LIV promotes both proliferation and differentiation. Our lab and others have identified that
LIV acts on MSCs through conserved cytoskeletal components (focal adhesions and LINC complex proteins) as well as through nearly ubiquitous cell signaling pathways (AKT-GSK3b pathway). In T cells, the AKT-GSK3b pathway plays a particularly important role as it is involved in CC28 co-stimulation and subsequent activation of the T cell. My preliminary results have shown that T cells are in fact mechanosensitive to vibration. I have demonstrated that LIV applied to in-vitro culture can increase T cell number by 30% over 5 days and alter the expression of activation-associated surface receptors such as CD62L, CD69, and PD-1. Some of our most recent work indicates that LIV may indeed by acting on the AKT-GSK3b pathway, as inhibition of this pathway eliminated the majority of vibration induced changes in T cell proliferation and activation.
Ultimately, funding from the Synder Scholars Program that supports this research will help further our understanding of cell mechanosensitivity, potentially helping to generate a non-invasive and non-pharmacologic method for enhancing both the proliferation and activation of T cells, leading to more effective manufacturing of CAR-T therapy.

August 2022

2022 BME Graduate Program Research Day 

After a long hiatus due to the COVID pandemic, the graduate program went back to his roots with an in-person research day that demonstrated the creativity and scientific rigors for our graduate students. The event included both oral and poster presentations and was followed by our not least traditional BBQ.

Students and faculties voted for their favorite presentations:

Students’ choice for the best oral presentation: Evan Lammertse

Development of Magnetized Balls of Acrylamide Gel (MAG-BAGs) for streamlined genomic workflows

Microfluidics for Quantitative and Genomic Biology, PI: Dr. Brouzes

 research day 1

 

Students’ choice for the best poster: Sai Sreenivasamurthy

Developing woven bone organoids as a therapy platform for bone regeneration

Zhu Lab, PI: Dr.  Zhu

sai

Faculties’ choice for the best oral presentation: Hailing Huang and Peineng Wang

Hailing Huang: Spectral simulation for a dual-layer detector for dual-energy contrast-enhanced breast imaging

Digital Radiological Imaging Laboratory, PI: Dr. Zhao

Peineng Wang: AI-Accelerated Multiscale Modeling For Platelet Adhesion Dynamics And Thrombus Formation At Millisecond and Molecular Resolutions

Biofluids Research Group, PI: Dr. Bluestein

hailiang

Faculties’ choice for the best poster: Joshua Azukas

Expression Dynamics Utilizing Low-Noise Optogenetic Circuits and Modified Cell Culture Substrates

Micro- and Nano-Technologies for Quantitative Biology  Quantitative Analysis of Single-Cell Protein, PI: Dr.  Strey

josh

Febrruary 2022

In Memoriam Shmuel Einav, 1942-2022

ShmuelA pillar of the biomedical engineering community and the field of biofluids and cardiovascular engineering- Prof. Shmuel Einav, passed away in Israel on February 20, 2022. Besides his major contributions to our field, Prof. Einav was an inspiring and beloved figure who was appreciated by many in the bioengineering community. During its nascent years, he was a part of a small group of visionary academics who helped establish biomedical engineering as an independent academic discipline and a prosperous research field. He received his B.S. in mechanical engineering in 1964 and M.S. in nuclear engineering in 1968 from the Technion, Israel Institute of Technology, followed by a Ph.D. in mechanical engineering in 1972 from Stony Brook University. At that time he developed his lifelong interest in the emerging field of bioengineering and pursued a postdoc in Physiology and Medicine at Boston University. Returning to Israel he became a faculty at Tel Aviv University (TAU) and rose through the academic ranks, while collaborating with leading researchers in the US and Europe. He led the process of granting advanced degrees in biomedical engineering and was the founding chair of the biomedical engineering department (1993). He then led other BME departments in Israel to offer undergraduate studies in Biomedical Engineering. Driven by boundless curiosity and always looking for innovative research directions, his research has led to new insights into the way we diagnose and treat cardiovascular diseases and develop cardiovascular devices. He was among the first to investigate and publish in 1975 on LDA measurements of the flow of red blood cells in the living body. His studies focused on the role of hemodynamics in the initiation of atherosclerosis, the dynamics of cardiovascular flows and the associated shear stress on vascular endothelial biology. Prof. Einav also served as a visiting professor at Boston University, Berkley, Caltech, and MIT. He was a fellow of ASME, BMES, AIMBE, ICMBE, member of several international academies, and past President of the Israeli Society for Medical and Biological Engineering. Prof. Einav was the driving force of the International Biofluid Symposium and Workshop and led and chaired its conferences from 2003 on. He returned in 2004 to his alma mater Stony Brook University where he served in leading roles until his retirement last year. Prof. Einav was an inspirational figure who saw himself as a mentor for young talent and facilitator of new ideas. He was a researcher, teacher, leader, mentor, and friend to many in the biomedical engineering community. He will be deeply missed.
The full article of JBME in Memoriam honoring Shmuel Einav's lifelong contribution can be
viewed via this link:

https://asmedigitalcollection.asme.org/biomechanical/article/144/8/080101/1141608/In-
Memoriam-Shmuel-Einav-1942-2022

January 2022

Alumni Spotlight: Philip Xie publication in Lab on a Chip entitled "Non-contact ultrasound oocyte denudation"

Philip is currently working in Weill Cornell Medicine in New York City as an academic staff as well as an embryologist. His work involves routine clinical andrology and embryology tasks in IVF laboratories as well as research projects involving artificial gametes, developmental biology, as well as designing and testing microfluidic devices to improve and revolutionize IVF lab workflow.

He worked on a team to develop a surface acoustic wave (SAW)-based microfluidic device to successfully achieve oocyte denudation with high efficiency and safety. Compared to the conventional denudation method currently used in IVF clinics, this novel automated device successfully minimized mechanical, thermal, and chemical stress with its safety proven by the generation of healthy mouse offspring. https://pubs.rsc.org/en/content/articlelanding/2022/lc/d1lc00715g/unauth

FEBRUARY 2021

Dr. Mujica-Parodi named a Fulbright Distinguished Scholar Award (2021-2022)

The Fulbright Distinguished Chair Awards comprise approximately forty distinguished lecturing, distinguished research and distinguished lecturing/research awards ranging from three to 12 months. Fulbright Distinguished Chair Awards are viewed as among the most prestigious appointments in the U.S. Fulbright Scholar Program. Candidates should be eminent scholars and have a significant publication and teaching record (definition from Wikipedia). Dr. Mujica-Parodi will be studying at the Department Physics of Complex Systems, Weizmann Institute of Science in Rohovot Israel.

JANUARY 2021

Sindhuja Tirumalai Govindaraj's, BME Graduate Student, Research Showcased on the Cover of Brain Sciences

Multiple sclerosis (MS) is a neurodegenerative disease that causes lesion formation and tissue loss or atrophy in the brain. Cognitive and motor challenges are commonly observed in people with MS. Reduced speed of information processing is typically the first sign of cognitive involvement, which in turn broadly affects other cognitive processes including attention, executive function, and memory. The Attention Network Test—Interactions can measure the efficiency of 3 distinct attentional processes—alerting, orienting, and executive control. In this study, we measured attentional efficiencies and gray matter morphometry in a sample of young adults (18–35 years) with relatively mild MS severity. We show that thickness and volume changes in specific gray matter regions correlate with attentional efficiency even in the absence of widespread atrophy.

The paper can be viewed here.

The cover can be viewed here.

NOVEMBER 2020

Dr. Danny Bluestein awarded the 2021 ASME Savio Woo Translational Biomechanics Medal

Dr. Bluestein has been named the 2021 recipient of the 2021 ASME Savio Woo Translational Biomechanics Medal for his seminal work on thrombosis that represents a paradigm shift in translating biomechanics research to clinical applications, and for meritorious cardiovascular disease studies and thromboresistance optimization in circulatory support devices. The formal presentation of the award will take place during the Summer Biomechanics, Bioengineering, and Biotransport Conference in June, 2021.

OCTOBER 2020

LILAC Enables BME Faculty to Purchase New Equipment

The laboratories of Dr. Brouzes from BME and Dr. Ju from Pathology) received funds from LILAC (Long Island League to Abolish Cancerto purchase a piece of small thermocycler. We recently received the flat thermocycler that will enable us to perform molecular reactions in flat microfluidic devices. This piece of equipment will be critical to pursue our cancer research projects, particularly for the development of our novel platform for spatial genomics. We are deeply grateful for the generosity of LILAC members and very proud to have LILAC as our partner in our cancer research efforts.

ThermocyclerThermocycler & Dr. Brouzes

NOVEMBER 2019

BME Undergraduate Design Team Wins 1st Place 

Congratulations to Nicole Hershkowitz, Sishir PasumarthyAlonzo Tabada, Vincent Destefano
Yosman Dhar for winning the 1st place award in the Wolfie Tank competition. The team received a $2000 cash prize and free consultation with a patent attorney. They developed a prototype for a novel clinical retractor for brain surgery during their Bioinnovation Summer Internship Program and continued the development of this innovation into their senior design project.

Design Team

JUNE 2019

Andrew Labella, BME Graduate Student, Lands ACS Photonics Cover

Picosecond timing in an avalanche amorphous selenium semiconductor is achieved by implementing Nano-Frisch grids along the collecting electrode to form a multiwell structure. The induced photocurrent following optical impulse exposure is independent of carrier motion outside the wells resulting in unipolar time-differential charge sensing via extended-state hot hole transport. This is the first experimental report of avalanche gain and picosecond time-resolution using an amorphous semiconductor. Further analysis suggests we may be able to achieve sub-100 picosecond coincidence timing resolution in time-of-flight PET using our multiwell selenium semiconductor as the photodetector. For the Goldan Lab click here or ACS Publications click here.

ACS Cover Labella

MAY 2019

Dr. David A. Rubenstein, Awarded the 2019 Faculty Award for Excellence

The Center for Inclusive Education at Stony Brook University, awarded Dr. David A. Rubenstein, Associate Professor and Director of the Graduate Program in Biomedical Engineering, the 2019 Faculty Award for Excellence.  The citation for this award reads: "In recognition of your commitment to diversity and outstanding contribution to mentoring at Stony Brook University." Congratulations to Dr. Rubenstein!

MARCH 2019

Graduate Students from Dr. Arbab's Lab Win Best Student Paper Award at OTST

Omar B. Osman and Andrew Chen from the Terahertz (THz) Biophotonics Laboratory, won a best student poster award at the eighth international conference on Optical Terahertz Science and Technologies (OTST) in Santa Fe, New Mexico. Omar and Andrew presented their work, titled A THz-TDS study of dehydration dynamics of corneal phantoms, where they report the simulation and validation of the water content of a corneal phantom using THz-TDS. Their poster was selected from approximately 100 poster presentations. This was the first step in the progression towards developing a non-invasive corneal imaging tool using THz imaging. Congratulations to Omar and Andrew!

Omar_Andrew_poster

JANUARY 2019

Journal Article by Dr. Bluestein, Ram Ghosh (Doctoral Candidate), Gil Marom (Post-doctoral Fellow) and Oren Rotman (Post-doctoral Fellow) Named as a JBME Editors' Choice for 2018

A recent publication from Dr. Bluestein's Biofluids Research Group, Comparative fluid-structure interaction analysis of polymeric transcatheter and surgical aortic valves' hemodynamics and structural mechanics” published as JBME 140(12):121002,  has been named as one of 12  JBME Editors' Choice papers for 2018. These selected papers represent those that the editorial board felt best exemplified the high quality and significance of work in JBME. Click here to  view a youtube animation of the work represented in this manuscript. This video was also featured on the ANSYS blog.

OCTOBER 15, 2017

SBU Chapter of AEMB Awarded 2 National awards

 The SBU Chapter of AEMB was awarded the "Best Community Service" and "Outstanding Chapter Advisor" Awards at the recent Annual Meeting of the Biomedical Engineering Society.  Congratulations on the amazing work from the SBU Chapter.

 AEMB Awards

October 14, 2017

TV Winner at the Annual BMES Conference

Congratulations to Nathan Ankomah-Mensah from the University of Rhode Island for winning our TV at the Annual BMES Conference.

TV Winner

OCTOBER 1, 2017

New Leadership Roles in Biomedical Engineering

On October 1, Dr. Clinton T. Rubin, Distinguished Professor and Founding Chair of Biomedical Engineering and Director of the Center for Biotechnology, rejoined the faculty to focus on research endeavors and the promotion of biotechnology and multiple levels. Dr. Stefan Judex, Professor of Biomedical Engineering, has been named as the interim chair. We want to take this opportunity to thank Dr. Rubin for all of his effort in forming the "BME Universe" at Stony Brook University and congratulate Dr. Judex on his new role for the BME department. More information about the new leadership roles can be found here.

August 25, 2017

Vihita Patel, BME Graduate Student, Publishes Findings in Obesity

Vihita is the first author on a publication that used an adult murine model of high fat diet induced obesity. This manuscript shows that obesity leads to adipose tissue dysfunction (increased visceral adiposity, adipocyte hypertrophy, chronic inflammation in adipose tissue, and reduced mesenchymal stem cell population in the adipose tissue) and consequently impaired glucose metabolism (increased glucose intolerance and insulin resistance). Subjecting these obese mice to a very low magnitude and high frequency mechanical stimulation (LMMS) for 6 weeks mitigates obesity-induced adipose tissue dysfunction and impaired glucose metabolism. However, LMMS is more effective when it is delivered in two bouts of 15 minutes per day separated by a 5 hour rest period, rather than one bout of 30 minutes per day. This study provides an insight into how exercise could be beneficial in obesity, emphasizing that with aging, the scheduling of the physical activity is at least as important, if not more, than the activity itself. It also demonstrates that LMMS, as a surrogate to exercise, can serve as a non-invasive and non-pharmacological treatment for obesity without requiring strenuous physical exertion. The entire article can be found here.

AUGUST 23, 2017

3 BME Faculty are Awarded Seed Funding for Cancer Research

2 teams partially composed of BME faculty members, Eric Brouzes, David A. Rubenstein and Helmut Strey are awarded funding for novel cancer research projects. This funding comes as part of the exciting Engineering Driven Medicine colloboration of the College of Engineering and Applied Sciences and the School of Medicine.

READ MORE

 

August 7, 2017

Nicholas Van Nest, BME Senior, Presents His Summer Research at Washington State University

Nicholas Van Nest presents his summer research conducted with the Center for Bioplastics and Biocomposites at the Washington State University Summer Research Symposium. His research involved the development of a bio-based synthesis pathway for a polymer adhesive, as an alternative to fossil fuel feedstocks. Congratulations.

Nick van Nest

August 7, 2017

Cerebrovascular adaptations to cocaine-induced transient ischemic attacks in the rodent brain" is published in JCI insight

Occurrence of transient ischemic attacks (TIA) and cerebral strokes is a recognized risk associated with cocaine abuse. Our research, for the first time, bridges the clinical observed cocaine induced transient ischemic attack (TIA) with the cerebral vascular disorder (e.g. vasoconstriction) by using cutting-edge optical imaging technology, ultrahigh-resolution optical coherence Doppler tomography developed in our lab. In this study, we reported longitudinal imaging to reveal the process of repeated cocaine induced vasoconstriction, TIA and hemiparalysis, and vasoadaptation including vascular redistribution and neoangiogenesis to partially ameliorate the symptom of TIA and brain damage.

Read More

July 26, 2017

Henry Towery, Class of '17, Motivated to Make a Difference

Henry Towery, Biomedical Engineering Alumni of the Class of 2017, is Motivated to making a difference in clincical research.

Read More 

JUNE 15, 2017

Michael Salerno, BME Graduate Student, Awarded the Chateaubriand Fellow

Congratulations to Michael Salerno, who has been named as a 2017-2018 Chateaubriand Fellow. He will be supported to study PET imaging in France for 9 months.

Read More

JUNE 9, 2017

Andrew Kumpfbeck, a BME major (Class of 2018), named URECA Researcher of the Month

Congratulations to Andrew for being named as the URECA researcher of the month. He is currently working with Dr. Prives (Pharmacological Sciences) and Dr. Frame (BME).

Read More

JUNE 9, 2017

Eric Brouzes, BME Assistant Professor, Discusses A Recent Publication in Lab on A Chip

Recently, technologies based on droplet microfluidics have enabled the development of novel platforms to facilitate single-cell analysis, paving the way towards a better understanding of the role of tissue heterogeneity in the development of diseases such as cancer. Platforms relying on droplets microfluidics operate at very high-throughput and are unable to reliably deposit one individual cell per droplet. Both aspects hinder the development of droplet-based devices for processing samples of limited availability such as needle biopsies or isolated CTCs.
In this Lab on a Chip communication, we introduce an innovative strategy for the preparation of precious samples for single-cell analysis. Individual cells from the sample are captured using hydrodynamic traps before introducing an oil phase which sequentially surrounds the cell-occupied chambers. This results in the generation of numerous droplets, each containing a single cell. The encapsulated cells can then be retrieved from the platform for analysis using established droplet-based technologies. Our device efficiently encapsulates hundreds of individual cells into droplets while exhibiting no sample loss, effectively laying the foundations for the single-cell analysis of rare samples via droplet microfluidics.

Read More | Full Text PDF

MAY 4, 2017

Dr. Clinton Rubin, BME Distinguished Professor and Chair, and Director of Center for Biotechnology, Talks on Improving SBIR and STTR Programs

Dr. Clinton Rubin talks NIH-REACH program as catalyst for tech & econ dev at joint congressional hearing. Start video at 2:53 to hear Dr. Rubin's remarks.

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APRIL 10, 2017

Dr. Danny Bluestein, BME Professor, Awarded a New Grant

Congratulations to Danny Bluestein who has received a Phase 1 STTR grant entitled "A novel polymeric valve for transcatheter aorta valve replacement. This is a 2 year grant for a total of $225,000.

APRIL 10, 2017

Dr. Gabor Balazsi, BME Associate Professor, Awarded NIH Grant

Congratulations to Dr. Balazsi and his team for being awarded a 5 year NIH grant entitled "Dynamics and Evolution of Synthetic and Natural Gene Regulatory Networks."

APRIL 4, 2017

Gabor Balazsi, BME Associate Professor, Named as a Discovery Prize Finalist

Stony Brook has earned its stellar reputation as a prestigious research institution because of its many breakthrough discoveries — such as developing the technology for the MRI — made during the past several decades. In a time of dwindling federal funding, it is crucial that we continue to support fundamental research and encourage our greatest minds to pursue the big ideas that transform lives and make an impact around the world.
With this in mind, we established the Discovery Prize in 2013 with a generous donation from the Stony Brook Foundation Board of Trustees. The Prize is awarded to an early-career Stony Brook faculty member in the STEM disciplines whose pioneering project embraces risk and innovation and embodies the potential of discovery-driven research — the catalysts for scientific advances.

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APRIL 3, 2017

Dr. Qin on Capitol Hill; Advocating for NIH Research Funding

As a delegate for the American Academy of Orthopaedic Surgeons (AAOS), Dr. Qin went to Washington for a Research Capitol Hill Days. Their goal is to encourage Congress and Senate to pass NIH FY 2017 bill ($34.1B) and FY 2018 bill ($36.1B). This is a critical year. The whole team represents total of 24 orthopaedic related societies. The small group includes an orthopaedic surgeon, Dr. Gary Brock, a Victoria Secret supermodel, Martha Hunt, as a patient advocate, and Dr. Qin as a researcher. They visited both NY and TX Congress and Senate Offices, including Chuck Schumer, Lee Zeldin, John Cornyn, Kristen Gillibrand, Nita Lowey, and John Culberson. It was a very busy and productive day, but absolutely worthwhile. Their voices were heard loudly. Their impression is that to keep and/or increase NIH budget, it must be supported in bipartisan at least for these two States. Both Senators and Congressman/Congresswoman are willing to fight for NIH.

JANUARY 23, 2017

Stony Brook Ranked #7 for percent of students from the bottom fifth of the income distribution who end up in the top three-fifths

Stony Brook was recently ranked by the New York Times as one of America's Great Working-Class colleges.

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OCTOBER 25, 2016

Shu Jia, BME Assistant Professor, Awarded 2 Prestigious Awards

The National Science Foundation and the Defense Advanced Research Projects Agency has funded two projects focused on the development of new super-resolution light microscope for both imaging of cells, tissues and organ systems and specifically will try to develop an understanding of the brain. Congratulations to Shu and his research team!

SEPTEMBER 27, 2016

Amna Haider, BME Junior, Featured on PSEG LI Investing in the Future of Stem

Congratulations to Amna for her research work this summer, funded by PSEG LI, to look into the role of cocaine on bone mechanical/physical properties. Amna is currently working on the direction of Drs Ete Chan and Clint Rubin. Bruce Coluccio, a BME Sophomore, and Robert Bruce, a Physics Major, also work with Drs Chan and Rubin over the summer in this project. Congratulations to all for their important work.

Read More

SEPTEMBER 20, 2016>

Assistant Professor, Shu Jia, has been named as a DARPA Young Faculty Awardee

The awarded project entitled: "Wavefront-Engineered, High-Speed Super-Resolution Microscopy for Nanometer-Scale, Live-Tissue Imaging" is at the forefront of super resolution microscopy.
The advancement of our understanding of biology has been greatly reliant on observations of cells. Light microscopy, especially fluorescence microscopy, has evolved to observe smaller specimens with greater resolution. The spatial resolution of a microscope is defined as the smallest distance in an image in which two distinct points can be distinguished. Because of the diffraction of light, resolution had previously been thought to have a theoretical limit from what is called Abbe's diffraction limit of light (~200-300 nanometers). Recent emergence of super-resolution imaging techniques has surpassed this limit, allowing visualization of cellular and sub-cellular structures with ~10-20 nanomater resolution at the near-molecular-scale. This advance provides thriving opportunities for exploring the complex structure, dynamics and function of biological molecules. Due to the significant impact of these new techniques, the 2014 Nobel Prize in Chemistry was awarded to the development of super-resolution fluorescence microscopy.
The research in the Jia Laboratory aims to enhance this resolving power across unexplored regimes in space and time to attain a better understanding of the molecular basis for the functions of tissues and organisms. To achieve the goal, the group investigates the physical and engineering principles underlying single-molecule imaging in complex biological materials, and utilizes these principles to develop new biophotonic methods for super-resolution microscopy. These methods include optical physics, optical wavefront engineering, single-molecule biophysics, adaptive optics, phase microscopy, large-data processing, advanced instrumentation, nano-fabrication, etc.
One super-resolution imaging method currently under investigation is called stochastic optical reconstruction microscopy (STORM), which relies on imaging of single molecules to reconstruct fluorescence images with sub-diffraction-limit resolution. In biological systems, how these single-molecule mechanisms are integrated over larger scales is critical for understanding physiological functions and disease initiation of complex biological systems. There remains a great demand in an enabling technology to extract such single-molecule information and dynamics across large volumes of specimen with ultra-high spatiotemporal resolution.
The DARPA award will support the lab's development of a new super-resolution microscopy system for in vivo investigations of cell, tissue and organ functions. The research will base on the lab's expertise in a technique called point spread function engineering, which can modify how light is propagated within an imaging system to achieve better imaging capability. By exploring and implementing a new type of optical non-diffracting waveforms, the light within a microscope can propagate in a dramatically different way from normal light. One typical feature is that it will not spread out as much as described by the usual diffraction effect of light. This allows people to image further deeper into biological samples. In addition, it also provides better 3D resolution and is more robust to scattering effect in biological tissues.
First trained as an applied physicist and electrical engineer and later into a bioimaging expert, Dr. Jia is passionate about advancing imaging technology with new physical concepts and engineering design. The highly interdisciplinary team consists of experts from physics, computer science, engineering, and biology. In collaboration with researchers both within the Department of Biomedical Engineering and elsewhere, the lab expects their new technologies would provide new insights and solutions to challenges in biological and ultimately clinical research.

AUGUST 16, 2016

James Scheuermann wins First Place

Congratulations to BME Ph.D. Candidate, James Scheuermann who won first place in the John R. Cameron Young Investigators Competition held by the American Association of Physicists in Medicine.

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AUGUST 1, 2016

Ete Chan wins SUNY Funding to Develop a Virtual Lab

Ete Chan, Assistant Professor, has received funding which will explore and develop the creation of virtual labs for Biomedical Engineering students. She is the leader of a group of biomedical engineering faculty and students and computer science faculty and students that will implement this project. Congratulations.

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JULY 22, 2016

ASEE TV Highlights CEAS Research and Educational Mission

Dr. Ete Chan and BME Junior Amna Haider were featured on the ASEE Highlights of CEAS Research and Education. Congratulations.