Faculty
Arnold Wishnia, Research Associate Professor Emeritus
A.B., 1952, Cornell University
Ph.D., 1957, New York University
Postdoctoral Fellow, Yale University, 1956-1959
Special (Senior) Fellow, USPHS, University of Edinburgh, 1967
International Exchange Visitor, INSERM, Institut de Biologie Physico-Chimique, Paris,
1978 and 1982
Maître de Recherche, Ecole Polytechnique, Palaiseau, 1989-1990
203 Duchess Hall
Email: arnold.wishnia@stonybrook.edu
Biochemistry
The structure and behavior of a variety of macromolecules and macromolecular systems (proteins, nucleic acids, ribosomes, phospholipid vesicles) have been studied by several techniques. For example, processes related to initiation of protein synthesis were studied by stopped-flow or pressure-jump light-scattering or fluorescence, as well as by more "classical" techniques of molecular biology. The behavior of ribosomes as polyelectrolytes is a continuing interest. The mechanism of cation-induced fusion of phospholipid vesicles--models for the behavior of biological membranes--was probed by stopped-flow fluorescence and light-scattering, while the nature of the vesicle surfaces was investigated by 31P NMR and fluorescence lifetime studies of the interaction with lanthanide cations. NMR has been used over the years to explore problems in protein and nucleic acid behavior. Currently, the emphasis is on magnetic resonance imaging using laser-polarized 129Xe.
Publications
Use of magnetic resonance imaging for noninvasive characterization and follow-up of an experimental injury to normal mouse muscles. Wishnia A, Alameddine H, de Gery ST, Leroy-Willig A. NEUROMUSCULAR DISORDERS, 11 (1): 50-55 JAN 2001
Magnetic susceptibility shift selected imaging (MESSI) and localized (H2O)-H-1 spectroscopy in living plant tissues. Zhong K, Li X, Shachar-Hill Y, Picart F, Wishnia A, Springer CS. NMR IN BIOMEDICINE, 13 (7): 392-397 NOV 2000
In vivo MR imaging and spectroscopy using hyperpolarized Xe-129. Wagshul ME, Button TM, Li HFF, Liang ZR, Springer CS, Zhong K, Wishnia. AMAGNETIC RESONANCE IN MEDICINE, 36 (2): 183-191 AUG 1996
Hyperpolarized xe-129 magnetic-resonance spectroscopy and imaging of the living mouse. Wishnia A, Button T, Li H, Wagshul ME. FASEB JOURNAL, 9 (6): A1386-A1386 APR 24 1995