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2017 Publications

Daryaee F, Zhang Z, Gogarty KR, Li Y, Merino J, Fisher SL, and   PJ Tonge. 2017. A quantitative mechanistic PK/PD model directly connects Btk target engagement and in vivo efficacy.  Chem. Sci. 8:3434-3443.

Gil AA, Laptenok SP, Iuliano JN, Lukacs A, Verma A, Hall CR, Yoon E, Brust R, Greetham GM, Towrie M, French JB, Meech SR,   and  PJ Tonge. 2017. Photoactivation of the BLUF protein PixD probed by the site-specific incorporation of fluorotyrosine residues.  J. Am. Chem. Soc. doi: 10.1021/jacs.7b07849.

Huang H, Rodolis MT, Bhatia SR, and   NS Sampson. 2017. Sugars require rigid multivalent displays for activation of mouse sperm acrosomal exocytosis.  Biochemistry. 56:2779-2786. 

Lu R, Schaefer CM, Nesbitt NM, Kuper J, Kisker C, and   NS Sampson. 2017. Catabolism of the cholesterol side chain in   Mycobacterium tuberculosis  is controlled by a redox-sensitive thiol switch.  A. C. S. Infect. Dis.  2017 Aug 16. doi: 10.1021/acsinfecdis.7b00072.

McLaughlin PA, McClelland M, Yang HJ, Porwollik S, Bogomolnaya L, Chen JS, Andrews-Polymenis H, and   AW van der Velden. 2017. Contribution of asparagine catabolism to salmonella virulence.   Infect. Immunity.  85: e00740-16.

Mladinich MC, Schwedes J, and   ER Mackow. 2017. Zika virus persistently infects and is basolaterally released from primary human brain microvascular endothelial cells.   MBio. 2017 Jul 11;8(4). pii: e00952-17.

Neckles C, Eltschkner S, Cummings JE, Hirschbeck M, Daryaee F, Bommineni GR, Zhang Z, Spagnuolo L, Yu W, Davoodi S, Slayden RA, Kisker C,   and  PJ Tonge. 2017. Rationalizing the binding kinetics for the inhibition of the Burkholderia pseudomallei FabI1 Enoyl-ACP reductase.  Biochemistry. 56:1865-1878.

Puri N and   AW Karzai. 2017. HspQ functions as a unique specificity-enhancing factor for the AAA+ Lon protease.  Mol. Cell.  66:672-683.

Romagnoli PA, Fu HH, Qiu Z, Khairallah C, Pham QM, Puddington L, Khanna KM, Lefrancois L, and  BS Sheridan . 2017. Differentiation of distinct long-lived memory CD4 T cells in intestinal tissues after oral  Listeria monocytogenes  infection.  Mucosal Immunol.  10:520-530. 

Spagnuolo LA, Eltschkner S, Yu W, Daryaee F, Davoodi S, Knudson SE, Allen EK, Merino J, Pschibul A, Moree B, Thivalapill N, Truglio JJ, Salafsky J, Slayden RA, Kisker C,   and  PJ Tonge. 2017. Evaluating the contribution of transition-state destabilization to changes in the residence time of triazole-based InhA inhibitors.  J. Am. Chem. Soc.  139:3417-3429.

PJ Tonge. 2017. Drug-target kinetics in drug discovery.  A. C. S Chem Neurosci. doi: 10.1021/acschemneuro.7b00185.

Touchette MH and   JC Seeliger. 2017. Transport of outer membrane lipids in mycobacteria.  Biochim. Biophys. Acta. pii: S1388-1981(17)30011-2

Touchette MH, Van Vlack ER, Bai L, Kim J, Cognetta AB 3rd, Previti ML, Backus KM, Martin DW, Cravatt BF, and   JC Seeliger. 2017. A screen for protein-protein interactions in live Mycobacteria reveals a functional link between the virulence-associated lipid transporter LprG and the Mycolyltransferase antigen 85A.  A. C. S. Infect. Dis. 3:336-348.

Van Vlack ER, Topp S, and   JC Seeliger. 2017. Characterization of engineered PreQ1 riboswitches for inducible gene regulation in Mycobacteria.  J. Bacteriol. 199(6). pii: e00656-16.

Zhang Z, Ordonez AA, Smith-Jones P, Wang H, Gogarty KR, Daryaee F, Bambarger LE, Chang YS, Jain SK,   and  PJ Tonge. 2017. The biodistribution of 5-[18F]fluoropyrazinamide in Mycobacterium tuberculosis-infected mice determined by positron emission tomography. PLoS One. 12:e0170871.

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