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Recent Publications

Structure and inhibition of Cryptococcus neoformans sterylglucosidase to develop antifungal agents. Pereira de Sa N, Taouil A, Kim J, Clement T, Hoffmann RM, Burke JE, Rizzo RC, Ojima I, Del Poeta M, Airola MV. Nat Commun. 2021 Oct 7;12(1):5885. doi: 10.1038/s41467-021-26163-5. PMID: 34620873 

The middle lipin domain adopts a membrane-binding dimeric protein fold. Gu W, Gao S, Wang H, Fleming KD, Hoffmann RM, Yang JW, Patel NM, Choi YM, Burke JE, Reue K, Airola MV. Nat Commun. 2021 Aug 5;12(1):4718. doi: 10.1038/s41467-021-24929-5. PMID: 34354069 

Crystal structure of human PLD1 provides insight into activation by PI(4,5)P2 and RhoA. Bowling FZ, Salazar CM, Bell JA, Huq TS, Frohman MA, Airola MV. Nat Chem Biol. 2020 Apr;16(4):400-407. doi: 10.1038/s41589-020-0499-8. Epub 2020 Mar 16. PMID: 32198492 

Crystal structure of a lipin/Pah phosphatidic acid phosphatase. Khayyo VI, Hoffmann RM, Wang H, Bell JA, Burke JE, Reue K, Airola MV. Nat Commun. 2020 Mar 11;11(1):1309. doi: 10.1038/s41467-020-15124-z. PMID: 32161260 

Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613 Moises O. Guardado Rivas ,Shawn D. Stuart ,Daniel Thach,Michael Dahan, Robert Shorr, Zuzana Zachar, Paul M. Bingham 
Published: June 8, 2022

Wang, CD., Xu, S., Chen, S., Chen, ZH., Dean, N., Wang, N. and Gao, XD. 2022. An in vitro assay for human ALG13/14 heterodimeric UDP-N-acetylglucosamine transferase.  Frontiers in Cell and Developmental Biology

Dean, N., Jones, R., DaSilva, J., Chionchio, G. and Ng, H. 2022. Mnn10/Anp1-dependent N-linked outer chain glycan is dispensable for Candida albicans cell wall integrity.  Genetics

Xiang, MH, Xu, XX, Wang, CD, Chen,S. Xu,S, Xu, XY, Dean, N., Wang, N and Gao, XD. 2022. Topological and enzymatic analysis of human Alg2 mannosyltransferase reveals its role in lipid-linked oligosaccharide biosynthetic pathway.  Communication Biology

Neupane S, Berardinelli SJ, Cameron DC, Grady RC, Komatsu DE, Percival CJ, Takeuchi M, Ito A, Liu TW, Nairn AV, Moremen KW, Haltiwanger RS, Holdener BCO-fucosylation of thrombospondin type 1 repeats is essential for ECM remodeling and signaling during bone development. Matrix Biol. 2022 Mar;107:77-96. doi: 10.1016/j.matbio.2022.02.002. Epub 2022 Feb 12. PMID: 35167946

Jones FK, Phillips A, Jones AR, Pisconti AThe INSR/AKT/mTOR pathway regulates the pace of myogenesis in a syndecan-3-dependent manner. Matrix Biol. 2022 Sep 21. doi: 10.1016/j.matbio.2022.09.004