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Yue Zhang, Ph.D.
Laboratory of Dr. James Bliska

Ph.D., 1999, Stony Brook University

Select Publications:
Zhang Y, Tam JW, Mena P, van der Velden AW, and JB Bliska. 2015. CCR2+ inflammatory dendritic cells and translocation of antigen by type III secretion are required for the exceptionally large CD8+ T cell response to the protective YopE69-77 epitope during Yersinia infection. PLoS Pathog. 11(10):e1005167. PMID: 26468944

Zhang Y, Mena P, Romanov G, and JB Bliska. 2014. Effector CD8+ T cells are generated in response to an immunodominant epitope in type III effector YopE during primary Yersinia pseudotuberculosis infection. Infect. Immun. 82(7):3033-3044. PMID: 24799630

McPhee JB, Mena P,   Zhang Y, and JB Bliska. 2012. Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM. Infect. Immun. 80:2519-2527. PMID: 22547545

Zhang Y, Mena P, Romanov G, Lin JS, Smiley ST, and JB Bliska. 2012. A protective epitope in the type III effector YopE is a major CD8 T cell antigen during primary infection with Yersinia pseudotuberculosis. Infect. Immun. 80:206-214. PMID: 22064714

Zhang Y, Romanov G and JB Bliska. 2011. Type III secretion system-dependent translocation of ectopically expressed Yop effectors into macrophages by intracellular Yersinia pseudotuberculosis. Infect. Immun. 79:4322-4331. PMID: 21844228

Zheng Y, Lilo S, Brodsky IE,   Zhang Y, Medzhitov R, Marcu KB, and JB Bliska. 2011. A Yersinia effector with enhanced inhibitory activity on the NF-kB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages. PLoS Pathog. 7(4):e1002026. PMID: 21533069

Zhang Y  and JB Bliska. 2011. Mathematical relationship between cytokine concentrations and pathogen levels during infection. Cytokine. 53:158-162. PMID: 21093285

Zhang Y  and JB Bliska. 2010. YopJ-promoted cytotoxicity and systemic colonization are associated with high levels of murine interleukin-18, gamma interferon, and neutrophils in a live vaccine model of Yersinia pseudotuberculosis infection. Infect. Immun. 78:2329-2341. PMID: 20231414

Zhang Y, Murtha J, Roberts MA, Siegel RM, and JB Bliska. 2008. Type III secretion decreases bacterial and host survival following phagocytosis of Yersinia pseudotuberculosis by macrophages. Infect. Immun. 76:4299-4310. PMID: 18591234

Zhang Y, Ting AT, Marcu KB, and JB Bliska. 2005. Inhibition of MAPK and NF-kappaB pathways is necessary for rapid apoptosis in macrophages infected with Yersinia. J. Immunol. 174:7939-7949. PMID: 15944300

Zhang Y  and JB Bliska. 2005. Role of macrophage apoptosis in the pathogenesis of Yersinia. Curr. Top. Microbiol. Immunol. 289:151-173. PMID: 15791955

Zhang Y  and JB Bliska. 2003. Role of Toll-like receptor signaling in the apoptotic response of macrophages to Yersinia infection. Infect. Immun. 71:1513-1519. PMID: 12595470

Zhang Y. 2002. Rapid Amplification of cDNA Ends. Generation of cDNA libraries P13-22. Edited by Ying, S. Y., Humana Press Inc., Totowa, NJ. PMID: 12703729

Zhang Y, Redina O, Altshuller YM, Yamazaki M, Ramos J, Chneiweiss H, Kanaho Y, and MA Frohman. 2000. Regulation of expression of phospholipase D1 and D2 by PEA-15, a novel protein that interacts with them. J. Biol. Chem. 275:35224-35232. PMID: 10926929

Frohman MA, Kanaho Y,   Zhang Y, and AJ Morris. 2000. Regulation of phospholipase D1 activity by Rho GTPases. Methods Enzymol. 325:177-189. PMID: 11036603

Zhang Y  and MA Frohman. 2000. Using rapid amplification of cDNA ends (RACE) to obtain full-length cDNAs. Nucleic Acids Protocols Handbook P 267-288. Edited by Rapley, R., Humana Press Inc., Totowa, NJ. PMID: 22547545

Zhang Y,  Altshuller YM, Hammond SM, Hayes F, Morris AJ and MA Frohman. 1999. Loss of receptor regulation by a phospholipase D1 mutant selectively unresponsive to protein kinase C. EMBO J. 18:6339-6348. PMID: 10562546

Yamazaki M,   Zhang Y, Watanabe H, Yokozeki T, Ohno S, Kaibuchi K, Shibata H, Mukai H, Ono Y, Frohman MA, and Y Kanaho. 1999. Interaction of the small G protein RhoA with the C terminus of human phospholipase D1. J. Biol. Chem. 274:6035-6038. PMID: 10037681

Sung TC,   Zhang Y, Morris AJ, and MA Frohman. 1999. Structural analysis of human phospholipase D1. J. Biol. Chem. 274:3659-3666. PMID: 9920915

Sung TC, Roper RL,   Zhang Y, Rudge SA, Temel R, Hammond SM, Morris AJ, Moss B, Engebrecht J, and MA Frohman. 1997. Mutagenesis of phospholipase D defines a superfamily including a trans-Golgi viral protein required for poxvirus pathogenicity. EMBO J. 16:4519-4530. PMID: 9303296

Zhang Y  and MA Frohman. 1998. Cloning cDNA ends using RACE. Methods Mol. Med. 13:81-105. PMID: 21390839

Zhang Y  and MA Frohman. 1997. Using rapid amplification of cDNA ends (RACE) to obtain full-length cDNAs. Methods Mol. Biol. 69:61-87. PMID: 9116864

Huang H, Tudor M, Su T,   Zhang Y, Hu Y, and H Ma. 1996. DNA binding properties of two Arabidopsis MADS domain proteins: binding consensus and dimmer formation. Plant Cell. 8:81-94. PMID: 8597661

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