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Laurie Krug Assistant Professor Molecular Genetics and Microbiology School of Medicine

Contact Information

216-A Life Sciences Bldg.

Stony Brook, 11794

631/632-9055

Biography

Laurie Krug’s research interests lie in understanding the molecular determinants of virus-host interactions during chronic infections caused by human gammaherpesviruses: Epstein-Barr virus (EBV) and Kaposi’s sarcoma associated-herpesvirus (KSHV). Her research of these critical virus-cell interactions will provide a greater understanding of these disorders and can lead to novel therapeutic targets. Her laboratory uses genetic knock-out and CRISPR tools to identify virus and host determinants in a model pathogen system.

Education

  • PhD, Emory University
  • BS, University of South Carolina-Coastal

Research Grants

Award Start End Sponsor Type Amount Status
Function of Gammaherpesvirus ORF75 Tegument Proteins 2012-03-01T00:00:00 2015-02-28T00:00:00 National Institute of Allergy & Infectious Disease Federal 426976 Closed
Regulation of Gammaherpesvirus Latency by NF-kappaB Signaling 2011-07-01T00:00:00 2016-06-30T00:00:00 American Cancer Society Nonfederal 720000 Closed
Uracil DNA Glycosylases in Herpesvirus Pathogenesis and DNA Mutation 2014-04-01T00:00:00 2017-03-31T00:00:00 National Institute of Allergy & Infectious Disease Federal 446788 Closed
Functional Analysis of STAT3 in Gammaherpesvirus Infection 2015-05-15T00:00:00 2018-04-30T00:00:00 National Institute of Allergy & Infectious Disease Federal 1336213 Approved
Uracil DNA Glycosylates in Gammherpesvirus Pathogenesis and B Cell Development 2016-06-01T00:00:00 2017-12-31T00:00:00 University of Texas MD Anderson Cancer Center Nonfederal 143885 Approved
SBIR: CRISPR-Cas9 Systems Delivered by Targeted Nanoparticles to Eradicate Herpesvirus Pathogens 2017-04-01T00:00:00 2018-03-31T00:00:00 Theragnostic Technologies Incorporated Nonfederal 94792 Approved

Publications

  1. Author Article Journal of Virology Tiled Microarray Identification of Novel Viral Transcript Structures and Distinct Transcriptional Profiles During Two Modes of Productive Murine Gammaherpesvirus 68 Infection 2012
  2. Author Article American Journal of Respiratory Cell and Molecular Biology Role of Endoplasmic Reticulum Stress in Age-Related Susceptibility to Lung Fibrosis 2012
  3. Author Article The American Journal of Pathology Inhibition of NF-?B Signaling Reduces Virus Load and Gammaherpesvirus-Induced Pulmonary Fibrosis 2010 177 2 608 - 621
  4. Author Article Journal of Virology NF- B p50 Plays Distinct Roles in the Establishment and Control of Murine Gammaherpesvirus 68 Latency 2009 83 10 4732 - 4748
  5. Author Article Journal of Experimental Medicine A gammaherpesvirus-secreted activator of V 4+ CD8+ T cells regulates chronic infection and immunopathology 2008 205 3 669 - 684
  6. Author Article PLoS Pathogens Inhibition of NF-?B Activation In Vivo Impairs Establishment of Gammaherpesvirus Latency 2007 3 1
  7. Author Article Journal of Virology A Gammaherpesvirus 68 Gene 50 Null Mutant Establishes Long-Term Latency in the Lung but Fails To Vaccinate against a Wild-Type Virus Challenge 2006 80 3 1592 - 1598
  8. Author Article Blood The targeting of primary effusion lymphoma cells for apoptosis by inducing lytic replication of human herpesvirus 8 while blocking virus production 2005 105 10 4028 - 4034
  9. Author Article Journal of Virology Inhibition of Infection and Replication of Human Herpesvirus 8 in Microvascular Endothelial Cells by Alpha Interferon and Phosphonoformic Acid 2004 78 15 8359 - 8371
  10. Author Article Journal of Virology Short Duration of Elevated vIRF-1 Expression during Lytic Replication of Human Herpesvirus 8 Limits Its Ability To Block Antiviral Responses Induced by Alpha Interferon in BCBL-1 Cells 2004 78 12 6621 - 6635
  11. Author Article Journal of Virology Variable Methylation of the Epstein-Barr Virus Wp EBNA Gene Promoter in B-Lymphoblastoid Cell Lines 2004 78 24 14062 - 14065

Courses

Term Role Course ID Description
Spring 2017 Primary Instructor BIO 487 Rsrch in Molec Cell & Dev Bio
Spring 2017 Primary Instructor HBM 692 Experimental Methods in Molec
Spring 2017 Primary Instructor HBM 699 Dissertation Resrch on Campus
Fall 2017 Primary Instructor HBM 599 Grad. Res. in Mol. Gen.& Micro
Fall 2017 Primary Instructor HBM 640 Molec Mech of Microb Pathoge
Fall 2017 Primary Instructor HBM 699 Dissertation Resrch on Campus
Spring 2016 Primary Instructor HBM 692 Experimental Methods in Molec
Spring 2016 Primary Instructor HBM 699 Dissertation Resrch on Campus
Fall 2016 Primary Instructor HBM 699 Dissertation Resrch on Campus
Spring 2015 Primary Instructor BIO 487 Rsrch in Molec Cell & Dev Bio
Spring 2015 Primary Instructor HBM 599 Grad. Res. in Mol. Gen.& Micro
Spring 2015 Primary Instructor HBM 699 Dissertation Resrch on Campus
Fall 2015 Primary Instructor HBM 599 Grad. Res. in Mol. Gen.& Micro
Fall 2015 Primary Instructor HBM 699 Dissertation Resrch on Campus
Spring 2014 Primary Instructor BIO 487 Rsrch in Molec Cell & Dev Bio
Spring 2014 Primary Instructor HBM 599 Grad. Res. in Mol. Gen.& Micro
Spring 2014 Primary Instructor HBM 699 Dissertation Resrch on Campus
Fall 2014 Primary Instructor BIO 487 Rsrch in Molec Cell & Dev Bio
Fall 2014 Primary Instructor HBM 599 Grad. Res. in Mol. Gen.& Micro
Fall 2014 Primary Instructor HBM 695 Advanced Readings in Molecular
Fall 2014 Primary Instructor HBM 699 Dissertation Resrch on Campus
Fall 2014 Primary Instructor HBM 699 Dissertation Resrch on Campus
Fall 2013 Primary Instructor BIO 487 Rsrch in Molec Cell & Dev Bio
Fall 2013 Primary Instructor BIO 487 Rsrch in Molec Cell & Dev Bio
Fall 2013 Primary Instructor HBM 699 Dissertation Resrch on Campus
Fall 2013 Primary Instructor HBM 699 Dissertation Resrch on Campus

Scholarly Activities

Activity Title Date
Seminar Of Mice and Herpes: NF-kappaB signaling is a critical determinant of gammaherpesvirus pathogenesis. 2012.Department of Microbiology and Molecular Genetics of UMDNJ-New Jersey Medical School. Newark, NJ. 2012-02
Presentation/Paper at a conference A Santana, K Bulaklak, and LT Krug. Investigating the role of NF-κB in the regulation of MHV68 gene expression. 2012. International Congress on Oncogenic Viruses and Associated Diseases. Philadelphia, PA. 2012
Presentation/Paper at a conference B Cieniewicz, N Carpino, and LT Krug. Role of T cell regulators STS1 and STS2 in gammaherpesvirus pathogenesis and immune control. 2012. International Congress on Oncogenic Viruses and Associated Diseases. Philadelphia, PA. 2012
Presentation/Paper at a conference E Abernathy, K Clyde, J Richner, L Coscoy, L Krug, and B Glaunsinger. Global mRNA degradation influences gammaherpesvirus gene expression and replication. 2012. International Congress on Oncogenic Viruses and Associated Diseases. Philadelphia, PA. 2012
Presentation/Paper at a conference N Minkah, R Stockton, J. Law, and LT Krug. Distinct roles for ORF75A and ORF75B tegument proteins in murine gammaherpesvirus pathogenesis. 2012. International Congress on Oncogenic Viruses and Associated Diseases. Philadelphia, PA. 2012
Presentation/Paper at a conference Cheng, BHY, J Zhi, A Santana, S Khan, SS Reddy, Y Zheng, S Jaggi, J Leatherwood, and LT Krug. 2011. Hybrid Microarray Analysis of a Model Gammaherpesvirus Pathogen during De novo Infection and upon Reactivation from Latency Reveals Distinct Transcriptomes. 13th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies. Bethesda, MD. 2011-12
Presentation/Paper at a conference Minkah, NK, R Stockton, JC Forrest, and LT Krug. 2011. Roles for MHV68 ORF75A and ORF75B Tegument Proteins in Gammaherpesvirus Pathogenesis. 2nd ASM Conference on Manipulationof Nuclear Processes by DNA viruses. Santa Fe, NM. 2011-12
Seminar Connecting the dots: NF-kappaB signaling and gammaherpesvirus pathogenesis. 2011. Stony Brook Molecular Genetics and Microbiology Departmental Retreat. Stony Brook, NY. 2011-12
Workshop Speaker, Group discussion NIH IRACDA post-doctoral program, PennPORT, University of Pennsylvania, Philadelphia, PA 2011-04-18
Seminar NF-kappaB signaling: A key host determinant of gammaherpesvirus pathogenesis". 2010. New York University School of Medicine Microbiology Department. New York, NY. 2010-08
Presentation/Paper at a conference Krug, LT, EM Torres-Gonzales, A Stecenko, KL Brigham, SH Speck, and AL Mora. 2009. Inhibition of NF-kappa B signaling reduces virus persistence and identifies a role for the SDF-1/CXCR4 axis in a murine model of gammaherpesvirus-associated pulmonary fibrosis. Kaposi’s Sarcoma Associated Herpesvirus and Related Agents 12th International Workshop. Charleston, SC. 2009-09
Presentation/Paper at a conference Krug, LT. LM Gargano, AG Evans, CR Paden, and SH Speck. 2009. The absence of M1 leads to higher establishment of MHV68 latency in memory B cells. 34th International Herpesvirus Workshop, Ithaca, NY. 2009-02

Professional Service

Service Title Date
Referee Reviewer for PLoS Pathogens 2011 - 2012
Other Ad Hoc Reviewer, PLoS Pathogens, Journal of General Virology 2010 - 2011
Service on Editorial Boards Ad hoc reviewer, Journal of Virological Methods, Viruses, and American Journal of Pathology 2009 - 2010

University Service

Service Title Date
Administrative Work Assignment Organizer Molecular Genetics and Microbiology Departmental Retreat 2011 - 2012
College/University Committee School of Medicine Curriculum Committee 2011 - 2012
Community Activity Math and Science Night at Mount Elementary School 2011 - 2012
Departmental Committee Genetics Admissions Committee 2011 - 2012
Departmental Committee Molecular and Cellular Biology Admissions Commitee 2011 - 2012
Departmental Committee Molecular and Cellular Biology Graduate StudentQualifying Exam Committee 2011 - 2012
Departmental Committee Molecular Genetics and Microbiology Cancer Biology Curriculum Committee 2011 - 2012
Other Workshop Panelist, “Tailor Your Application” Office of Postdoctoral Affairs, Stony Brook University 2011 - 2012
Community Activity Organizer, Mount Elementary Math, Science, and Technology Night 2010 - 2011
Departmental Committee Cancer Biology Curriculum Committee 2010 - 2011
Departmental Committee Graduate Student Qualifying Exam Committee 2010 - 2011
Departmental Committee Graduate Students: Ha Youn Shin, Ann Marie Torres, Jason Tam 2010 - 2011
College/University Committee Faculty Forward Task Force 2009 - 2010
College/University Committee Faculty Senate 2009 - 2010
Community Activity Career Day volunteer at Mount Elementary School. 2009 - 2010
Departmental Committee Faculty search committee 2009 - 2010
Departmental Committee Organizer, Annual Departmental Retreat 2009 - 2010

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