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Enhancing Responses to Chemical Interventions by Programmed Introduction of Multiple Refractory Periods
A medical device that can deliver multiple, brief intervention doses over a 24 hour period that improves cell biologic responses.
Source: Anusorn,,


The ability of any exogenous intervention, be it physical or chemical in nature, to influence cell activity is markedly enhanced by incorporating a rest period between stimulation periods within any given 24 hour period. Thus, a 24 hour period does not need to transpire before the biologic responsiveness to a given stimulus is ?reset.?


Researchers at Stony Brook University created an invention which indicates that the potency of a given intervention can be improved, and the biologic response enhanced, by delivering it via multiple, brief doses over a day, rather than single doses in any given day. In the context of a medical device that delivers an electric or mechanical signal, the ability of that intervention to upregulate a cell response is improved by waiting at least 1 hour before introducing the signal again and is improved even more by waiting 3 hours. This allows for multiple periods of stimulus over a given day, and the outcome is improved as compared to a single dose given once per day.


Builds on the responsiveness of the biologic system. - Can also be used in non-human applications, such as timing/optimizing yields in recombinant stills in bioprocessing or agriculture.


Introduces rest periods between stimulation periods within a 24 hour period to increase the effectiveness of exogenous intervention.


Clinton Rubin, Distinguished Professor, Biomedical Engineering

Licensing Potential

Development partner - Commercial partner - Licensing

Licensing Status

Available for license. Stony Brook seeks to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area.

Licensing Contact

Sean Boykevisch, Director, Intellectual Property Partners,, 6316326952

Patent Status


Some in-vitro data is available. PCT Publication No. WO 2012-051495

Tech Id