Research in structural biology provides the foundation for understanding life at the molecular and atomic levels. The Center for Structural Biology at Stony Brook brings together cutting‑edge technologies and expert faculty to explore the architecture, dynamics, and mechanisms of biological macromolecules.
A central strength of the Center is its advanced cryo-electron microscopy (cryoEM) facility, which enables high‑resolution visualization of protein complexes, membrane assemblies, and other challenging targets in near‑native states. Complementing these capabilities, the Center also supports state‑of‑the‑art X‑ray crystallography, allowing researchers to determine precise three‑dimensional structures of proteins, nucleic acids, and large macromolecular assemblies.
The Center’s interdisciplinary environment spans faculty from Biochemistry and Cell Biology, Chemistry, Pharmacological Sciences, Physiology and Biophysics, and related departments. Stony Brook’s close partnership with Brookhaven National Laboratory further enhances research opportunities, providing access to premier crystallographic beamlines and complementary resources at the National Synchrotron Light Source II.
Together, these facilities support a broad range of research opportunities for trainees and investigators, from visualizing molecular machines to deciphering mechanisms that drive cellular function. We welcome your interest in the Center for Structural Biology and invite you to explore the many avenues of discovery it offers.