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Guest Speaker

adrienne fairhall

Giulio Tononi  
David P. White Chair in Sleep Medicine and Distinguished Chair in Consciousness Science, University of Wisconsin

Dr. Tononi’s laboratory studies consciousness and its disorders as well as the mechanisms and functions of sleep. For his work on sleep, he has received the   NIH  Director’s Pioneer Award (2005) and the Harvard Medical School’s Farrell Prize in Sleep Medicine (2017) for his outstanding lifetime contributions to the field. For his work on consciousness, he has received the Max Planck Institute’s Klaus Joachim Zülch Prize (2017) and the Leibniz Institute for Neurobiology’s Leibniz Chair (2018). Dr. Tononi is also the recipient of the Academy of Sleep and Consciousness’s Bernese Sleep Award (2018) and the Humboldt Foundation’s distinguished Humboldt Research Prize (2018).

Dr. Tononi’s main contribution in the study of sleep has been the development of a comprehensive hypothesis about the function of sleep, the synaptic homeostasis hypothesis. According to the hypothesis, sleep serves to renormalize synaptic strength, counterbalancing a net increase of synaptic strength due to plasticity during wakefulness. On the basis of the   synaptic homeostasis hypothesis, Dr. Tononi and his long-term collaborator Dr. Chiara Cirelli have shown (using molecular and electrophysiological markers in both invertebrates, rodents, and humans) that synaptic strength does in fact increase during wake and decrease during sleep in much of the brain. Moreover, using a combination of genetic, molecular, and electrophysiological approaches, they have found that sleep need is increased by the amount of plastic changes during wake and that sleep can be induced on a local basis by learning and plasticity. Studies in humans also show that sleep slow waves are important for brain restoration and performance enhancements, with implications for the understanding of sleep disorders (e.g., parasomnias), the neurobiology of mood disorders, and the beneficial effects of sleep deprivation on depression. Dr. Tononi’s laboratory has also demonstrated that patients with schizophrenia show a characteristic reduction of sleep spindles—a hallmark of the sleep   EEG—pointing to an impairment of a specific region of the thalamus that could account for many of the symptoms.

Dr. Tononi’s main contribution in the study of consciousness has been the development of the   integrated information theory. This is a comprehensive theory of what consciousness is, what determines its quantity and quality, and how it emerges from causal structures such as neural networks. The theory provides a parsimonious account of many neuropsychological observations, among them why certain parts of the brain give rise to experience and others do not, why consciousness vanishes during slow wave sleep and seizures despite continuing neural activity, and how unconscious processes interact with conscious ones. The theory has implications for the unfolding of consciousness across development and phylogeny, and predicts which ingredients are necessary and sufficient to construct sentient machines.

 

 

 

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