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Hoi-Chung Leung, Ph.D

Northwestern University (1997)
Professor, Integrative Neuroscience


Office: Psychology B-314
Phone: (631) 632-7820

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Dr. Leung plans to admit a new graduate student pending approval of funding.

Research Interests:

Cognitive neuroscience, spatial working memory, action control, eye movement control, neuroimaging.

Current Research:

Dr. Leung's primary research interest is in understanding the neural basis of cognitive processes, with particular emphasis on the contribution of the prefrontal cortex. In the past, I studied the activity of the prefrontal cortex and other cortical areas during cognitive interference and visual-spatial working memory using functional magnetic resonance imaging (fMRI). Current research continues on investigating the functional organization of the human prefrontal cortex and its interaction with posterior association areas and subcortical areas. We are studying the human prefrontal circuits during processing different forms of visual information and its role in recognition/response selection using fMRI. The lab is also interested in understanding the relationship between the abnormalities of the prefrontal cortex and cognitive dysfunctions observed in patients with psychiatric and neurological disorders.

Book Chapters:

Goldman-Rakic, P. S., & Leung, H.-C. (2002). Functional architecture of the dorsolateral prefrontal cortex in monkeys and man. In D. T. Stuss & R. T. Knight (Eds.), Principles of Frontal Lobe Function (pp. 85-95). New York: Oxford University Press.

Representative Publications:

Le, T.M, Huang, A.S., O'Rawe, J.F., & Leung, H.-C.  Functional neural network configuration across cognitive states in late childhood show age- and state-dependent integration and flexibility Developmental Cognitive Neuroscience In press

Kann, S.,  Chang CP, Manza P,  & Leung, H.-C.  (2020)   Akinetic Rigid Symptoms are Associated with Decline in a Cortical Motor Network in Parkinson’s Disease NPJ  Parkinson's Disease   6, Article number: 19 | doi: 10.1038/s41531-020-00120-3

O'Rawe, J. F., & Leung, H.-C.  (2020)  Topographic mapping as a basic principle of functional organization for visual and prefrontal functional connectivity e Neuro.  7 (1): ENEURO.0532-19.2019

O'Rawe, J. F., Huang, A., Klein, D., & Leung, H.-C.  (2019)  Posterior parietal influences on visual network specialization during development: an fMRI study of functional connectivity in children ages 9 to 12.  Neuropsychologia. 127: 158-170.  PMID:  30849407 .

O'Rawe J, Ide JS, Leung H-C.  (2019)  Model testing for distinctive functional connectivity gradients with resting-state fMRI data. Neuroimage. 185: 102-110 PMID:  30315909 .

Manza, P.,  Schwartz, G., Masson, M., Kann, S., Volkow, N.D., Li, C.R.,  Leung, H.-C.  (2018)  Levodopa  improves response inhibition and enhances striatal activation in early-stage Parkinson's disease. Neurobiol Aging. 66: 12-22 PMID:  29501966 .

Kann, S., O'Rawe, J., Huang, A., Klein, D.N., & Leung, H.-C. (2017). Preschool Negative Emotionality Impacts Activity and Connectivity of the Fusiform Face Area and Amygdala at Later Childhood. Social Cognitive and Affective Neuroscience. In press

Manza, P., Amandola, M., Li, Tatineni, V., C.S., & Leung, H.-C. (2017) Response Inhibition in Parkinson’s Disease: A Meta-Analysis of Dopaminergic Medication and Disease Duration Effects. npj Parkinson's Disease. 3, 23. doi:10.1038/s41531-017-0024-2.

Li, L,, Li, B., Bai, Y., Wang, H., Leung, H.-C., Liu, W., Tian, P., Zhang, L., Guo, F., Cui, L.-B., Yin, H., LU, H., & Tan, Q. (2017) Abnormal Resting State Effective Connectivity within the Default Mode Network in Major Depressive Disorder: A Spectral Dynamic Causal Modeling Study. Brain and Behavior.  7(7):e00732.

Sabharwal, A., Kotov, R., Szekely, A., Leung, H.-C., Barch, D., & Mohanty, A. (2017) Neural markers of emotional face perception across psychotic disorders and general population. J Abnormal Psychology. 126(5):663-678.

Le, T.M., Borghi, J.A., Kujawa, A.J., Klein, D.N., & Leung, H.-C. (2017) Alterations in visual cortical activation and connectivity with prefrontal cortex during working memory updating in major depressive disorder.  NeuroImage: Clinical. 14:43-53.

Kann, S, Zhang, S., Manza, P., Leung, H.-C. & Li, C.S. (2016) Hemispheric lateralization of resting state functional connectivity of the anterior insula: association with age, gender, and a novelty seeking trait. Brain Connectivity. Brain Connectivity. 6(9): 724-734

Manza, P., Hu, S., Ide, J.S., Farr, O.M., Zhang, S., & Leung, H.-C. & Li, C.S. (2016) The effects of methylphenidate on cerebral responses to conflict anticipation and unsigned prediction error in a stop signal task. Journal of Psychopharmacology. 30(3):283-93.

Huang, A., Klein, D.N., & Leung, H.-C. (2016) Load-related brain activation predicts spatial working memory performance in youth aged 9-12 and is associated with executive function at earlier ages.  Developmental Cognitive Neuroscience. 17:1-9.

Manza, P., Zhang, S., Li, C.S., & Leung, H.-C. (2016) Resting-state functional connectivity of the striatum in early-stage Parkinson’s disease: cognitive decline and motor symptomatology. Human Brain Mapping. 37(2):648-62.

Manza, P., Zhang, S.; Hu, S.; Chao, H., Leung, H.-C., & Li, C.S. (2015) The effects of age on resting state functional connectivity of the basal ganglia from young to middle adulthood. Neuroimage. 107:311–322

Manza, P., Hau, C.V., & Leung, H.-C. (2014) Alpha Power Gates Relevant Information during Working Memory Updating. Journal of Neuroscience. 34(17):

Cai, W., Cannistraci, C., Gore, J.C., & Leung, H.-C. (2014) Sensorimotor-independent prefrontal activity during response inhibition. Human Brain Mapping

Driesen, N.R., McCarthy, G., Bhagwagar Z., Bloch, M.H., Calhoun, V., D'Souza, D.C., Gueorguieva, R., He, G., Leung, H.-C., Ramachandran, R, Anticevic, A, Suckow, R., Morgan, P.T., & Krystal, J.H.(2013).The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity. Neuropsychopharmacology. 38(13): 2613-22

Han, X., Berg, A.C., Oh, H., Samaras, D., & Leung, H.-C. (2013) Multi-voxel pattern analysis of selective representation of visual working memory in ventral temporal and occipital regions.Neuroimage. 73: 8-15.

Honorio, J., Tomasi, D., Goldstein, R.Z., Leung, H.-C., & Samaras, D. (2012) Can a Single Brain Region Predict a Disorder? IEEE Transactions on Medical Imaging. 31(11):2062-72..

Cai, W., & Leung, H.-C. (2011). Rule-guided Executive Control of Response Inhibition: Functional Topography of the Inferior Frontal Cortex. PloS One. 6(6), e20840.

Yi, Y., & Leung, H.-C. (2011) Linear and nonlinear prefrontal and parietal activity during multiple-item working memory. Neuroimage.

Oh, H., & Leung, H.-C. (2010). Specific and non-specific neural activity during selective processing of visual representations in working memory. Journal of Cognitive Neuroscience.

Current Research Support:

Fronto-striatal circuitry in Parkinson's Disease. (Hartman Foundation) PI: Hoi-Chung Leung. Total Budget: $20, 000 (Awarded)