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Daniel Klein, Ph.D.


State University of New York at Buffalo (1983)
Distinguished Professor, Clinical Psychology

Klein

Contact:

daniel.klein@stonybrook.edu
Office: Psychology A-338
Phone: (631) 632-7859

Visit Lab Website

Visit Temperament Study Website

Dr. Klein plans to admit a new graduate student pending approval of funding

Research Interests:

Dr. Klein is interested in developmental psychopathology and adult psychopathology, particularly mood disorders in children, adolescents, and adults. His research explores the intergenerational transmission of depression; the roles of temperament and emotional reactivity, and early adversity in the development and course of mood disorders; the long-term course and continuity of mood disorders; the classification of mood disorders; comorbidity between depression and other disorders; and the psychotherapeutic and psychopharmacological treatment of depressive disorders.

Current Research:  

Dr. Klein is currently directing a longitudinal study of the role of early temperament and emotional style in the development of later mood and anxiety disorders in a large community sample of children (the Stony Brook Temperament Study). The children were assessed at ages 3, 6, 9, 12, and 15; the age 18 assessment is currently underway. The study uses multiple measurement strategies to assess potential risk, protective, mediating, and moderating factors in multiple domains, including child emotional reactivity and regulation, psychopathology, psychophysiological and behavioral measures of processing of emotional information, polygenic risk scores, stress and pubertal hormones, parenting, environmental and family stress, stressful life events, and parental personality and psychopathology. In addition, resting state and task-related functional magnetic resonance imaging (fMRI) measures were collected on a subset of the larger sample. Together with Dr. Roman Kotov (Psychiatry), Dr. Klein is also directing a longitudinal study of a large sample of early adolescent girls who have been followed on six occasions to age 20 (the Adolescent Development of Emotions and Personality Traits study). This project also seeks to identify antecedents of, and pathways to, depressive disorders, and uses many of the same measures as the Stony Brook Temperament Study.

 

Selected Publications since 2018

Finsaas, M.C., Bufferd, S.M., Dougherty, L.R., Carlson, G.A., & Klein, D.N. (2018). Preschool psychiatric disorders: Homotypic and heterotypic continuity through middle childhood and early adolescence. Psychological Medicine, 48, 2159-2168.

Goldstein, B.L., Kotov, R., Perlman, G., Watson, D., & Klein, D.N. (2018). Trait and facet-level predictors of first-onset depressive and anxiety disorders in a community sample of adolescent girls. Psychological Medicine, 48, 1282-1290.

Kessel, E.M., Nelson, B.D., Kujawa, A., Hajcak, G., Bromet, E., Kotov, R., Carlson, G.A. & Klein, D.N. (2018). Hurricane Sandy-related stress exposure alters the development of neural reactivity to negative stimuli in children. Child Development, 89, 339-348.

Kopala‐Sibley, D. C., Olino, T., Durbin, E., Dyson, M. W., & Klein, D. N. (2018). The stability of temperament from early childhood to early adolescence: A multi‐method, multi‐informant examination. European Journal of Personality, 32, 128-145.

Meyer, A., Hajcak, G., Torpey-Newman, D., Kujawa, A., Olino, T.M., Dyson, M., & Klein, D.N. (2018). Early temperamental fearfulness and the developmental trajectory of error-related brain activity. Developmental Psychobiology, 60, 224-231.

Meyer, A., & Klein, D.N. (2018). Examining the relationships between error-related brain (ERN) activity and anxiety disorders versus externalizing disorders in young children: Focusing on cognitive control, fear, and shyness. Comprehensive Psychiatry, 87, 112-119

Meyer, A., Nelson, B., Perlman, G., Klein, D.N., & Kotov, R. (2018). A neural biomarker, the error-related negativity, predicts the new onset of generalized anxiety disorder in a large sample of adolescent females. Journal of Child Psychology and Psychiatry, 59, 1162-1170.

Nelson, B.D., Infantolino, Z.P., Klein, D.N., Perlman, G., Kotov, R., & Hajcak, G.  (2018). Time-frequency reward-related delta prospectively predicts adolescent-onset depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 3, 41-49.

Olino, T.M., Bufferd, S.J., Dougherty, L.R., Dyson, M.W., Carlson, G.A., & Klein, D.N.  (2018). The development of latent dimensions of psychopathology across early childhood: Stability of dimensions and moderators of change . Journal of Abnormal Child Psychology, 46, 1373-1384.

Bartlett, E.A, Perlman, G., DeLorenzo, C., Klein, D.N., & Kotov, R. (2019). Stress-linked reductions in cortical morphometry in the onset of depression in adolescent females. Biological Psychiatry, 86, 769-778.

Black, S.R., Goldstein, B.L., & Klein, D.N. (2019). Parental depression moderates the relationships of cortisol and testosterone with children’s symptoms. Journal of Affective Disorders, 251, 42-51.

Frost, A., Kessel, E., Black, S., Goldstein, B., Bernard, K., & Klein, D.N. (2019). Homotypic and heterotypic continuity of internalizing and externalizing symptoms from age 3 to age 12: The moderating role of diurnal cortisol. Development and Psychopathology, 31, 789-798.

Kessel, E.M., Nelson, B.D., Finsaas, M., Kujawa, A., Meyer, A., Bromet, E., Carlson, G.A., Hajcak, G., Kotov, R., & Klein, D.N. (2019). Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children. Development and Psychopathology, 31, 1589-1598.

Kujawa, A., Hajcak, G., & Klein, D.N. (2019). Reduced reward responsiveness moderates the effect of maternal depression on depressive symptoms in offspring: Evidence across levels of analysis. Journal of Child Psychology and Psychiatry, 60, 82-90.

Mackin, D.M., Kotov, R., Perlman, G., Nelson, B.D., Goldstein, B.L., Hajcak, G., & Klein, D.N. (2019). Reward processing and future life stress: Stress generation pathway to depression. Journal of Abnormal Psychology, 128, 305-314.

Michelini, G., Barch, D.M., Tian, Y., Watson, D., Klein, D.N., & Kotov, R. (2019). Delineating and validating higher-order dimensions of psychopathology in the Adolescent Brain Cognitive Development (ABCD) study. Translational Psychiatry, 9, 261.

Neilsen, J.D., Olino, T.M., Dyson, M.W., & Klein, D.N. (2019). Reactive and regulatory temperament: Longitudinal associations with internalizing and externalizing symptoms through childhood. Journal of Abnormal Child Psychology, 47, 1771-1784.

Pegg, S.L., Dickey, L.I., Mumper, E., Kessel, E., Klein, D.N., & Kujawa, A. (2019). Stability and change in emotional processing across development: A 6-year longitudinal investigation using event-related potentials. Psychophysiology.e13438.

Araiza, A. M., Freitas, A. L., & Klein, D. (2020). Social-experience and temperamental predictors of rejection sensitivity: A prospective study. Social Psychological and Personality Science, 11, 733-742.

Finsaas, M.C., Kessel, E.M., Dougherty, L.R., Bufferd, S.J., Danzig, A.P., Davila, J., Carlson, G.A., & Klein, D.N. (2020). Early childhood psychopathology prospectively predicts social functioning in early adolescence. Journal of Clinical Child and Adolescent Psychology, 49, 353-364.

Goldstein, B.L., Kessel, E.M., Kujawa, A., Finsaas, M.C., Davila, J., Hajcak, G., & Klein, D.N. (2020). Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence. Psychological Medicine, 50, 1548-1555.

Goldstein, B.L., Perlman, G., Eaton, N.R., Kotov, R., & Klein, D.N. (2020). Testing explanatory models of interplay between depression, neuroticism, and stressful life events: A dynamic trait-stress generation approach. Psychological Medicine, 50, 2780-2789.

Gromatsky, M.A., He, S., Perlman, G., Klein, D.N., Kotov, R., & Waszczuk, M.A. (2020). Prospective prediction of first-onset of non-suicidal self-injury in adolescent girls. Journal of the American Academy of Child and Adolescent Psychiatry, 59, 1049-1057.

Gruber, J., Borelli, J.L., Prinstein, M.J., Clark, L.A., Davila, J., Gee, D.G., Klein, D.N., Levenson, R.W., Mendle, J., Olatunji, B.O., Rose, G.L., Saxbe, D., & Weinstock, L.M. (2020). Best practices in research mentoring in clinical science. Journal of Abnormal Psychology, 129, 70-81.

Hawes, M.T., Carlson, G.A., Finsaas, M.C., Olino, T.M., Seely, J.R., & Klein, D.N. (2020). Dimensions of irritability in adolescents: Longitudinal associations with psychopathology in adulthood. Psychological Medicine, 50. 2759-2767.

Klein, D.N. (2020). Persistent depressive disorder: Commentary on Parker and Malhi. Canadian Journal of Psychiatry, 65, 16-18.

Kopala-Sibley, D.C., Cyr, M., Finsaas, M.C., Orawe, J., Huang, A., Tottenham, N., & Klein, D.N. (2020). Early childhood parenting predicts late childhood brain functional connectivity during emotion perception and reward. Child Development, 91, 110-128.

Kujawa, A., Arfer, K.B., Finsaas, M., Kessel, E.M., Mumper, E., & Klein, D.N. (2020). Effects of maternal depression and mother–child relationship quality in early childhood on neural reactivity to rejection feedback and peer stress in adolescence: A 9-year longitudinal study. Clinical Psychological Science, 8, 657-672.

Mumper, E.E., Dyson, M.W., Finsaas, M.C., Olino, T.M., & Klein, D.N. (2020). Life stress moderates the effects of preschool behavioral inhibition on anxiety in early adolescence. Journal of Child Psychology and Psychiatry, 61, 167-174. 

Olino, T.M., Klein, D.N., & Seeley, J.R. (2020). Profiles of psychosocial and clinical functioning in adolescence and risk for later depression and other outcomes. Psychological Medicine, 50, 2066-2074.

*Schramm, E., *Klein, D.N., Elsaesser, M., Furukawa, T., & Domschke, K. (2020). Review of Persistent Depressive Disorder: History, correlates, and clinical implications. Lancet Psychiatry, 7, 801-812.

Silver, J., Olino, T.M., Carlson, G.A., & Klein, D.N. (2020). Offspring of mothers with histories of chronic and non-chronic depression: Symptom trajectories from ages 6 to 15. Frontiers Psychiatry, 11, 601779.

Kessel, E.M., Frost, A, Goldstein, B.L., Black, S.R., Dougherty, L.R., Carlson, G.A., & Klein, D.N. (2021). Developmental pathways from preschool irritability to multifinality in early adolescence: the role of diurnal cortisol. Psychological Medicine, 51 761-769.

Klein, D.N., Dougherty, L.R., Kessel, E.M., Silver, J., Carlson, G.A. (2021). A transdiagnostic perspective on youth irritability. Current Directions in Psychological Science, 30, 437-443.

Michelini, G., Perlman, G., Tian, Y., Mackin, D. M., Nelson, B. D., Klein, D. N., & Kotov, R. (2021). Multiple domains of risk factors for first onset of depression in adolescent girls. Journal of Affective Disorders, 283, 20-29.

Mumper, E.E., Finsaas, M.C., Goldstein, B.L., Gooding, D.C., & Klein, D.N. (2021). Developmental antecedents of social anhedonia: The roles of early temperament, parenting, and sex. Development and Psychopathology, 33, 363-371.

Olino, T., Michelini, G., Mennies, R.J., Kotov, R., & Klein, D.N. (2021). Does maternal psychopathology bias reports of offspring symptoms? A study using moderated non-linear factor analysis. Journal of Child Psychology and Psychiatry, 62, 1195-1201.

Silver, J., Carlson, G.A., Olino, T.M., Perlman, G., Kotov, R., & Klein, D.N. (2021). Differential outcomes of tonic and phasic irritability in adolescent girls. Journal of Child Psychology and Psychiatry, 62, 1220-1227.

Allmann, A.E., Kopala-Sibley, D.C., & Klein, D.N. (in press). Bidirectional and transactional relationships between parenting styles and child symptoms of ADHD, ODD, depression, and anxiety over six years. Development and Psychopathology.

Chad-Friedman, E., Galano, M.M., Lemay, E.P., Olino, T.M., Klein, D.N., & Dougherty, L.R. (in press). Parsing between- and within-person effects: Longitudinal associations between irritability and internalizing and externalizing problems from early childhood through adolescence. Development and Psychopathology.

Dale, K., Case, J.A.C., Dyson, M.W., Klein, D.N., & Olino, T.M. (in press). Childhood temperament as a predictor of adolescent non-suicidal self-injury. Development and Psychopathology.

Finsaas, M.C., & Klein, D.N. (in press). Is adult separation anxiety associated with offspring risk for psychiatric problems? Psychological Medicine.

Goldstein, B.L., Finsaas, M.C., Olino, T.M., Kotov, R., Grasso, D.J., & Klein, D.N. (in press). Three-variable systems: An integrative moderation and mediation framework for developmental psychopathology. Development and Psychopathology.

Gruber, J., Prinstein, M.J., Abramowitz, J.S., Albano, A.M., Aldao, A., Borelli, J.L., Chung, T., Clark, L.A., Davila, J., Forbes, E.E., Gee, D. G., Hall, G.C.N., Hallion, L.S., Hinshaw, S.P., Hofmann, S.G., Hollon, S.D., Joormann, J., Kazdin, A.E., Klein, D.N., La Greca, A.M., Levenson, R.W., MacDonald, A.W., McKay, D., McLaughlin, K.A., Mendle, J., Miller, A.B., Neblett, E.W., Nock, M.K., Olatunji, B.O., Persons, J.B., Rottenberg, J., Rozek, D.C., Schleider, J.L., Slavich, G.M., Teachman, B.A., Vine, V.J., Weinstock, L.M. (in press).  Mental health and clinical psychological science in the time of COVID-19: Challenges, opportunities, and a call to action.  American Psychologist.

Hawes, M.T., Finsaas, M.C., Olino, T.M., & Klein, D.N. (in press). Person-centered approach to understanding child temperament at ages 3 and 6: A latent profile analysis. European Journal of Personality.

Hawes, M.T., Szenczy, A.K., Klein, D.N., Hajcak, G., & Nelson, B.D. (in press). Increases in depression and anxiety symptoms in adolescents and young adults during the COVID-19 pandemic. Psychological Medicine.

Kujawa, A., Klein, D.N., Pegg, S., & Weinberg, A. (in press). Developmental trajectories to reduced activation of positive valence systems: A review of biological and environmental contributions. Developmental Cognitive Neuroscience.

Mu, W., Li, K., Tian, Y., Perlman, G., Michelini, G., Watson, D., Ormel, H., Klein, D.N., & Kotov, R. (in press). Dynamic risk for first onset of depressive disorders in adolescence: Does change matter? Psychological Medicine.

Pachankis, J.E., Clark, K.A., Klein, D.N., & Dougherty, L.R. (in press). Early Timing and determinants of the sexual orientation disparity in internalizing psychopathology: A prospective cohort study from ages 3 to 15. Journal of Youth and Adolescence.

Silver, J., Olino, T.M., Carlson, G.A., Dougherty, L.R., Bufferd, S.J., & Klein, D.N. (in press). Depression in early childhood: Clinical and psychosocial outcomes in late childhood and adolescence. Journal of Child Psychology and Psychiatry.

Sorcher, L.K., Goldstein, B.L., Finsaas, M.C., Carlson, G.A., Klein, D.N., & Dougherty, L.R. (in press). Preschool irritability predicts adolescent psychopathology and functional impairment: A 12-year prospective study. Journal of the American Academy of Child and Adolescent Psychiatry.

Current Research Support:

National Institute of Mental Health (RO1 MH 069942), "Temperamental emotionality in preschoolers and depression risk."
2004 - 2024. $7,289,330 (direct costs)
Principal Investigator (Co-Is: Gabrielle Carlson, Greg Hajcak, Joanne Davila, Thomas Olino)  

National Institute of Mental Health (R56 MH117116), “Gene expression and vulnerability to depression." 
2018-2020.  $940,865 (direct costs)
Multiple Principal Investigator with Roman Kotov

National Institute of Mental Health (RO1 MH118245 2019-2023), “Biopsychosocial mechanisms underlying internalizing psychopathology in a prospective population-based cohort of sexual minority young adults”.
2019-2023.  $113,180 (subcontract direct costs)
PI, subcontract, (PIs: Richard Branstrom, Mark Hatenbuehler, John Pachankis)

National Institute of Mental Health (RO1 MH 097767), “Trajectories of reward sensitivity and depression across adolescence”.
2018-2022. $2,588,487 (direct costs)
Co-Investigator (PI: Brady Nelson) 

National Institute of Occupational Safety and Health (U02 OH011321), “Personality-informed care model for 9/11-related comorbid conditions.”
2016-2021. $2,283,267 (direct costs)
Co-Investigator (PI: Roman Kotov) 

National Institute of Child Health and Development (R21 HD093912), “Using adolescent nonverbal behavior to predict aggression against bullies and bystanders”.
2018-2020. $275,000 (direct costs)
Co-Investigator, (PI: Johanna Jarcho)

Primary Mentor on Graduate Fellowship Awards:

National Science Foundation Graduate Research Fellowships to  Jamilah Silver