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HomeFacultyFaculty ProfilesDaniel Klein

Daniel Klein, Ph.D.

State University of New York at Buffalo (1983)
Distinguished Professor, Clinical Psychology

Klein

Contact:

daniel.klein@stonybrook.edu
Office: Psychology A-338
Phone: (631) 632-7859

Visit Lab Website

Visit Temperament Study Website

Dr. Daniel Klein plans to admit a new graduate student pending approval of funding.

Research Interests:

Dr. Klein is interested in developmental psychopathology and adult psychopathology, particularly mood disorders in children, adolescents, and adults. His research explores the intergenerational transmission of depression; the roles of temperament and emotional reactivity, and early adversity in the development and course of mood disorders; the long-term course and continuity of mood disorders; the classification of mood disorders; comorbidity between depression and other disorders; and the psychotherapeutic and psychopharmacological treatment of depressive disorders.

Current Research:  

Dr. Klein is currently directing a longitudinal study of the role of early temperament and emotional style in the development of later mood and anxiety disorders in a large community sample of children (the Stony Brook Temperament Study). The children were assessed at ages 3, 6, 9, 12, 15, and 18. The age 21 wave of assessments recently started. The study uses multiple measurement strategies to assess potential risk, protective, mediating, and moderating factors in multiple domains, including child emotional reactivity and regulation, psychopathology, psychophysiological and behavioral measures of processing of emotional information; ecological momentary assessment of mood and social interactions; polygenic risk scores, stress and pubertal hormones, parenting, stressful life events and chronic stress, and parental personality and psychopathology. In addition, resting state and task-related functional magnetic resonance imaging (fMRI) measures were collected on a subset of the larger sample. Together with Dr. Roman Kotov (Psychiatry), Dr. Klein is also directing a longitudinal study of a large sample of early adolescent girls who have been followed on six occasions to age 20 (the Adolescent Development of Emotions and Personality Traits study). This project also seeks to identify antecedents of, and pathways to, depressive disorders, and uses many of the same measures as the Stony Brook Temperament Study.

Selected Awards:

Distinguished Scientist Award, Society for a Science of Clinical Psychology (Section III, Division 12, American Psychological Association)

Joseph Zubin Award for Lifetime Contributions in Psychopathology, Society for Research in Psychopathology

Distinguished Scientific Contributions to Clinical Psychology, Society of Clinical Psychology (Division 12, American Psychological Association)

Lawrence H. Cohen Outstanding Mentor Award, Society for a Science of Clinical Psychology (Section III, Division 12, American Psychological Association)

John Neale Sustained Mentorship Award, Society for Research in Psychopathology                                                                                 

Dean’s Award for Excellence in Graduate Mentoring by a Faculty Member, Stony Brook University

Selected Articles since 2021:

2021

  1. Finsaas, M.C., & Klein, D.N. (2021). Adult separation anxiety: Personality characteristics of a neglected clinical syndrome. Journal of Abnormal Psychology, 130, 620–626.
  2. Gruber, J., Prinstein, M.J., Abramowitz, J.S., Albano, A.M., Aldao, A., Borelli, J.L., Chung, T., Clark, L.A., Davila, J., Forbes, E.E., Gee, D. G., Hall, G.C.N., Hallion, L.S., Hinshaw, S.P., Hofmann, S.G., Hollon, S.D., Joormann, J., Kazdin, A.E., Klein, D.N., La Greca, A.M., Levenson, R.W., MacDonald, A.W., McKay, D., McLaughlin, K.A., Mendle, J., Miller, A.B., Neblett, E.W., Nock, M.K., Olatunji, B.O., Persons, J.B., Rottenberg, J., Rozek, D.C., Schleider, J.L., Slavich, G.M., Teachman, B.A., Vine, V.J., Weinstock, L.M. (2021).  Mental health and clinical psychological science in the time of COVID-19: Challenges, opportunities, and a call to action. American Psychologist, 76, 409–426.
  3. Kessel, E.M., Dougherty, L.R., Hubacheck, S., Chad-Friedman, E., Olino,T., Carlson, G.A., Klein, D.N. (2021). Early predictors of adolescent irritability. Child and Adolescent Psychiatric Clinics of North America,30, 475-490.
  4. Kessel, E.M., Frost, A, Goldstein, B.L., Black, S.R., Dougherty, L.R., Carlson, G.A., & Klein, D.N. (2021). Developmental pathways from preschool irritability to multifinality in early adolescence: the role of diurnal cortisol. Psychological Medicine, 51 761-769.
  5. Klein, D.N., Dougherty, L.R., Kessel, E.M., Silver, J., Carlson, G.A. (2021). A transdiagnostic perspective on youth irritability. Current Directions in Psychological Science, 30, 437-443.
  6. Michelini, G., Perlman, G., Tian, Y., Mackin, D. M., Nelson, B. D., Klein, D. N., & Kotov, R. (2021). Multiple domains of risk factors for first onset of depression in adolescent girls. Journal of Affective Disorders, 283, 20-29.
  7. Mumper, E.E., Finsaas, M.C., Goldstein, B.L., Gooding, D.C., & Klein, D.N. (2021). Developmental antecedents of social anhedonia: The roles of early temperament, parenting, and sex. Development and Psychopathology, 33, 363-371.
  8. Olino, T., Michelini, G., Mennies, R.J., Kotov, R., & Klein, D.N. (2021). Does maternal psychopathology bias reports of offspring symptoms? A study using moderated non-linear factor analysis. Journal of Child Psychology and Psychiatry, 62, 1195-1201.
  9. Silver, J., Carlson, G.A., Olino, T.M., Perlman, G., Kotov, R., & Klein, D.N. (2021). Differential outcomes of tonic and phasic irritability in adolescent girls. Journal of Child Psychology and Psychiatry, 62, 1220-1227.
  10. Silver, J., Olino, T.M., Luby, J., Hawes, M.H., Carlson, G.A., & Klein, D.N. (2021). Reliability and validity of the Preschool Feelings Checklist. Research on Child and Adolescent Psychopathology, 49, 367-379.

2022

  1. Allmann, A.E., Kopala-Sibley, D.C., & Klein, D.N. (2022). Bidirectional and transactional relationships between parenting styles and child symptoms of ADHD, ODD, depression, and anxiety over six years. Development and Psychopathology, 34, 1400-1411.
  2. Burani, K., Brush, C.J., Shields, G.S., Slavich, G.M., Klein, D.N., Nelson, B., & Hajcak, G. (2022). Greater cumulative lifetime stressor exposure predicts a blunted RewP in adolescent girls over two years. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging,7, 1017-1024.
  3. Carlson, G.A., Silver, J., & Klein, D.N. (2022). The Emotional Outburst Inventory (EMO-I): Rating what children do when they are irritable. Journal of Clinical Psychiatry, 83, 39382. 
  4. Goldstein, B.L., Mackin, D.M., Miao, J., Perlman, G., Watson, D., Ormel, J., Klein, D.N., & Kotov, R. (2022). Is personality stable and symptoms fleeting? A longitudinal comparison in adolescence. Journal of Research in Personality, 97, 104190
  5. Hawes, M.T., Finsaas, M.C., Olino, T.M., & Klein, D.N. (2022). Person-centered approach to understanding child temperament at ages 3 and 6: A latent profile analysis. European Journal of Personality, 36, 91-107.
  6. Hawes, M.T., Szenczy, A.K., Klein, D.N., Hajcak, G., & Nelson, B.D. (2022). Increases in depression and anxiety symptoms in adolescents and young adults during the COVID-19 pandemic. Psychological Medicine, 52, 3222-3230.
  7. Hyland, S., Mackin, D.M., Goldstein, B.L., Finsaas, M.C., & Klein, D.N. (2022). Agreement, stability, and validity of parent- and self-reported youth anxiety symptoms from childhood to adolescence. Research on Child and Adolescent Psychopathology, 50, 1445-1455.
  8. Mackin, D. M., Finsaas, M. C., Nelson, B. D., Perlman, G., Kotov, R., & Klein, D. N. (2022). Intergenerational transmission of depressive and anxiety disorders: Mediation via youth personality. Journal of Psychopathology and Clinical Science, 131, 467-478.
  9. McGuinn, L.A., Tamayo-Ortiz, M., Rosa, M.J., Osorio-Valencia, E., Harari, H., Schnaas, L., Hernandez-Chavez, C., Wright, R.J., Klein, D.N., Téllez-Rojo, M.M., & Wright, R.O. (2022). The influence of maternal anxiety and cortisol during pregnancy on childhood anxiety symptoms. Psychoneuroendocrinology, 139, 105704.
  10. Mumper, E.E., Ferry, R.A., Klein, D.N., & Nelson, B.D. (2022). Effects of early childhood behavioral inhibition and parental anxiety disorder on adolescents’ startle response to predictable and unpredictable threat. Research on Child and Adolescent Psychopathology, 50, 1327-1338.
  11. Silver, J., Olino, T.M., Carlson, G.A., Dougherty, L.R., Bufferd, S.J., & Klein, D.N.(2022). Depression in early childhood: Clinical and psychosocial outcomes in late childhood and adolescence. Journal of Child Psychology and Psychiatry, 63, 984-991. 
  12. Sorcher, L.K., Goldstein, B.L., Finsaas, M.C., Carlson, G.A., Klein, D.N., & Dougherty, L.R. (2022). Preschool irritability predicts adolescent psychopathology and functional impairment: A 12-year prospective study. Journal of the American Academy of Child and Adolescent Psychiatry, 61, 554-564.
  13. Stewart, L.C., Mennies, R.J., Klein, D.N., & Olino, T.M. (2022).Measurement invariance of rumination across sex and development from late childhood through mid-adolescence. Cognitive Therapy and Research, 46. 573-579.

2023

  1. Ferry, R.A., Beatty, C., Klein, D.N., & Nelson, B.D. (2023). Family study of the startle reflex and event-related potentials in anticipation of predictable and unpredictable threat in adolescents and their parents. Psychophysiology
  2. Finsaas, M.C., & Klein, D.N. (2023). Is adult separation anxiety associated with offspring risk for psychiatric problems? Psychological Medicine,53 (7), 3168-3177.
  3. Goldstein, B.L., Finsaas, M.C., Olino, T.M., Kotov, R., Grasso, D.J., & Klein, D.N. (2023). Three-variable systems: An integrative moderation and mediation framework for developmental psychopathology. Development and Psychopathology, 35, 12-23.
  4. Hawes, M.T., Klein, D.N., Olino, T.M., & Kotov, R. (2023). Multi-method longitudinal investigation of the general factor of child temperament (GFT): Substantive phenomenon or methodological artifact? Journal of Research in Personality, 104, 104375.
  5. Klein, D.N., & Calentino, A.E. (2023). Depressive disorders. In: Friedman, H.S., Markey, C.H. (Eds.), Encyclopedia of Mental Health, vol. 1 (pp. 608-616). Elsevier, Academic Press.
  6. Mackin, D.M., Goldstein, B.L., Mumper, E., Kujawa, A.J., Kessel, E., Olino, T.M., Nelson, B.D., Hajcak, G., & Klein, D.N. (2023). Longitudinal associations between reward processing and depression across adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 62 (7), 816-828.
  7. Mu, W., Li, K., Tian, Y., Perlman, G., Michelini, G., Watson, D., Ormel, H., Klein, D.N., & Kotov, R. (2023). Dynamic risk for first onset of depressive disorders in adolescence: Does change matter? Psychological Medicine, 53, 2352-2360.
  8. Silver, J., Bufferd, S.J., Dougherty, L.R., Goldstein, B.L., Carlson, G.A., Klein, D.N. (2023). Tonic and phasic irritability in 6-year old children: Differential correlates and outcomes. Journal of Child Psychology and Psychiatry, 64, 234-243.
  9. Silver, J., Olino, T.M., Carlson, G.A., Dougherty, L.R., & Klein, D.N. (2023). Utility of self- and parent-reported suicidal ideation in early childhood: Prediction of suicidal ideation and psychopathology in adolescence. Suicide and Life Threatening Behavior, 53, 89-99.

MANUSCRIPTS IN PRESS

  1. Beatty, C.C., Ferry, R.A., Eaton, N.R., Klein, D.N., & Nelson, B.D. (in press). Neurobiological sensitivity to unpredictable threat and familial risk for the internalizing and externalizing spectra in adolescents. Psychological Medicine.
  2. Bränström, R., Pachankis, J.E., Klein, D.N., Jin., J., & Hatzenbuehler, M.L. (in press). Self-Schemas and information processing biases as mechanisms underlying sexual orientation disparities in depressive symptoms: Results from a longitudinal, population-based study. Journal of Psychopathology and Clinical Science.
  3. Burani, K., Brush, C.J., Shields, G.S., Klein, D.N., Nelson, B.D, Slavich, G.M., & Hajcak, G. (in press). Cumulative lifetime stress exposure interacts with reward responsiveness to predict longitudinal increases in depression severity in adolescence. Psychological Medicine.
  4. Chad-Friedman, E., Galano, M.M., Lemay, E.P., Olino, T.M., Klein, D.N., & Dougherty, L.R. (in press). Parsing between- and within-person effects: Longitudinal associations between irritability and internalizing and externalizing problems from early childhood through adolescence. Development and Psychopathology.
  5. Chad-Friedman, E., Jordan L., Chad-Friedman, S., Lemay, E., Olino, T. M., Klein, D. N., & Dougherty, L. R. (in press) Parent and child depressive symptoms and authoritarian parenting: Reciprocal relations from early childhood through adolescence. Clinical Psychological Science. 
  6. Chad-Friedman, S., Chad-Friedman, E., Lemay, E., Olino, T. M., Klein, D. N., & Dougherty, L. R. (in press). Within-person pathways among maternal depressive symptoms and offspring internalizing problems from early childhood through adolescence. Development and Psychopathology. 
  7. Clark, K.A., Pachankis, J.E., Dougherty, L.R., Katz, B.A., Hill, K., Klein, D.N., & Kujawa, A. (in press). Adolescents’ sexual orientation and behavioral and neural reactivity to peer acceptance and rejection: The moderating role of family support. Clinical Psychological Science.
  8. Dale, K., Case, J.A.C., Dyson, M.W., Klein, D.N., & Olino, T.M. (in press). Childhood temperament as a predictor of adolescent non-suicidal self-injury. Development and Psychopathology.
  9. Grieshaber, A., Vivian, D., & Klein, D.N. (in press). Treatment of chronic depression (Persistent Depressive Disorder). In Nemeroff, C.B., & Craighead, W.E. (Eds.), ADAA Patient Guide to Mood and Anxiety Disorders. Washington, DC: American Psychiatric Publishing.
  10. Hawes, M.T., Schwartz, H.A., Son, Y., & Klein, D.N. (in press). Predicting adolescent depression and anxiety from multi-wave longitudinal data using machine learning. Psychological Medicine.
  11. Klein, D.N. (in press). Assessment of depression. Assessment.
  12. Klein, D.N. (in press). Diagnosis and classification of depressive disorders. In Pettit, J.W., and Olino, T.M. (Eds.), APA Handbook of Depression, Washington, DC: American Psychological Association Press.
  13. Klein, D.N., Perlman, G., & Kotov, R. (in press). Pre-onset predictors of chronic-intermittent depression from early adolescence to early adulthood. Journal of Psychopathology and Clinical Science.
  14. McGuinn, L.A., Rivera, N.R., Osorio, E., Schnaas, L., Hernandez, C., Harari, H., Klein, D.N., Wright, R.J., Téllez-Rojo, M.M., Wright, R.O., Rosa, M.J., & Tamayo-Ortiz, M. (in press). Changes in depressive and anxiety symptoms in Mexican children during the COVID-19 pandemic. Pediatric Research.
  15. Merced-Nieves, F.M., Eitenbichler, S., Goldson, B., Zhang, X., Klein, D.N., Enlow, M.B., Curtin, P., Wright, R.O., & Wright, R.J., (in press). Associations between a metal mixture and infant negative affectivity: Effect modification by prenatal cortisol and infant sex. Child Development.
  16. Michelini, G., Gair, K., Tian, Y., Dougherty, L.R., Goldstein, B.L., MacNeill, L.A., Barch, D.M., Luby, J.L., Wakschlag, L.S., Klein, D.N., & Kotov, R. (in press). Do general and specific factors of preschool psychopathology predict preadolescent outcomes? A transdiagnostic hierarchical approach. Psychological Medicine.
  17. W., Huang, C., Yao, N., Mao, J., Perlman, G., Watson, D., Klein, D.N., & Kotov, R. (in press). Developmental pathway for first onset of depressive disorders: From adolescence to emerging adulthood. Psychological Medicine.
  18. Olino, T.M., Finsaas, M.C., Dyson, M.W., Carlson, G.A., & Klein, D.N. (in press). A multi-method, multi-informant study of early childhood temperament and depression and anxiety symptoms in adolescence. Journal of Psychopathology and Clinical Science.
  19. Pachankis, J. E., Hatzenbuehler, M. L., Klein, D. N., & Bränström, R. (in press). The role of shame in the sexual orientation disparity in mental health: A prospective population-based study of multimodal emotional reactions to stigma. Clinical Psychological Science.
  20. Silver, J., Bufferd, S.J., Dougherty, L.R., Goldstein, B.L., Carlson, G.A., Klein, D.N. (in press). Is the distinction between tonic and phasic irritability meaningful in 3-year-old children? European Child and Adolescent Psychiatry.
  21. Silver, J., Thorpe, D., Olino, T.M., & Klein, D.N. (in press). Intergenerational effects of parenting on children’s internalizing and externalizing trajectories: A latent growth model analysis. Child Psychiatry and Human Development.
  22. Sorcher, L.K., Mennies, R.J., Robeson, M., Seeley, J.R., Klein, D.N., Dougherty, L.R., & Olino, T.M. (in press). Offspring irritability: Associations with parental psychopathology and personality. European Child & Adolescent Psychiatry.
  23. Zhang, Y., Silver, J.I., Perlman, G., Kotov, R., Klein, D.N., & Eaton, N.R. (in press). Longitudinal stability and interrelations of tonic and phasic irritability in adolescent girls. Research in Child and Adolescent Psychopathology.

Recent Grant Support:

National Institute of Mental Health (RO1 MH 069942), "Temperamental emotionality in preschoolers and depression risk."
2004 - 2024. $7,289,330 (direct costs)
Principal Investigator (Co-I’s: Gabrielle Carlson, Greg Hajcak, Joanne Davila, Thomas Olino)  

National Institute of Mental Health (R56 MH117116), “Gene expression and vulnerability to depression." 
2018-2020.  $940,865 (direct costs)
Multiple Principal Investigator with Roman Kotov

National Institute of Environmental Health Science (R01 ES033436) “Prenatal metal-stress mixtures and transdiagnostic pathways to preadolescent internalizing disorder: Role of placental molecular signaling.”
2021–2026.  $154,293 (subcontract direct costs)
PI, subcontract (PI: Rosalind Wright)

National Institute of Mental Health (RO1 MH118245 2019-2023), “Biopsychosocial mechanisms underlying internalizing psychopathology in a prospective population-based cohort of sexual minority young adults”.
2019-2023.  $113,180 (subcontract direct costs)
PI, subcontract, (PIs: Richard Branstrom, Mark Hatenbuehler, John Pachankis)

National Institute of Mental Health (RO1 MH 097767), “Trajectories of reward sensitivity and depression across adolescence”.
2018-2022. $2,588,487 (direct costs)
Co-Investigator (PI: Brady Nelson) 

National Institute of Occupational Safety and Health (U02 OH011321), “Personality-informed care model for 9/11-related comorbid conditions.”
2016-2021. $2,283,267 (direct costs)
Co-Investigator (PI: Roman Kotov) 

Primary Mentor on  Fellowship Awards:

National Science Foundation Graduate Research Fellowships to  Jamilah Silver

National Institue of Mental health Dissertation Award to Jamilah Silver.

Israeli Science Foundation Post-Doctoral Research Fellowship to Benjamin Katz.

NIH-IRACDA NY-CAPS Postdoctoral Associate Fellowship to Benjamin Katz

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