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Daniel Klein, Ph.D.

State University of New York at Buffalo (1983)
Distinguished Professor, Clinical Psychology


Office: Psychology A-338
Phone: (631) 632-7859

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Visit Temperament Study Website

Dr. Klein plans to admit a new graduate student pending approval of funding.

Research Interests:

Dr. Klein is interested in developmental psychopathology and adult psychopathology, particularly mood disorders in children, adolescents, and adults. His research explores the intergenerational transmission of depression; the roles of temperament and emotional reactivity, and early adversity in the development and course of mood disorders; the long-term course and continuity of mood disorders; the classification of mood disorders; comorbidity between depression and other disorders; and the psychotherapeutic and psychopharmacological treatment of depressive disorders.

Current Research:  

Dr. Klein is currently directing a longitudinal study of the role of early temperament and emotional style in the development of later mood and anxiety disorders in a large community sample of children (the Stony Brook Temperament Study). The children were assessed at ages 3, 6, 9, 12, and 15; the age 18 assessment is currently underway. The study uses multiple measurement strategies to assess potential risk, protective, mediating, and moderating factors in multiple domains, including child emotional reactivity and regulation, psychopathology, psychophysiological and behavioral measures of processing of emotional information, polygenic risk scores, stress and pubertal hormones, parenting, environmental and family stress, stressful life events, and parental personality and psychopathology. In addition, resting state and task-related functional magnetic resonance imaging (fMRI) measures were collected on a subset of the larger sample. Together with Dr. Roman Kotov (Psychiatry), Dr. Klein is also directing a longitudinal study of a large sample of early adolescent girls who have been followed on six occasions to age 20 (the Adolescent Development of Emotions and Personality Traits study). This project also seeks to identify antecedents of, and pathways to, depressive disorders, and uses many of the same measures as the Stony Brook Temperament Study.

Selected Recent Publications: 

Goldstein, B.L., Kessel, E.M., Kujawa, A., Finsaas, M.C., Davila, J., Hajcak, G., & Klein, D.N. (in press). Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence. Psychological Medicine.

Gromatsky, M.A., He, S., Perlman, G., Klein, D.N., Kotov, R., & Waszczuk, M.A. (in press). Prospective prediction of first-onset of non-suicidal self-injury in adolescent girls. Journal of the American Academy of Child and Adolescent Psychiatry.

Gruber, J., Borelli, J.L., Prinstein, M.J., Clark, L.A., Davila, J., Gee, D.G., Klein, D.N., Levenson, R.W., Mendle, J., Olatunji, B.O., Rose, G.L., Saxbe, D., & Weinstock, L.M. (in press). Best practices in research mentoring in clinical science. Journal of Abnormal Psychology.

Gruber, J., Prinstein, M.J., Abramowitz, J.S., Albano, A.M., Aldao, A., Borelli, J.L., Chung, T., Clark, L.A., Davila, J., Forbes, E.E., Gee, D. G., Hall, G.C.N., Hallion, L.S., Hinshaw, S.P., Hofmann, S.G., Hollon, S.D., Joormann, J., Kazdin, A.E., Klein, D.N., La Greca, A.M., Levenson, R.W., MacDonald, A.W., McKay, D., McLaughlin, K.A., Mendle, J., Miller, A.B., Neblett, E.W., Nock, M.K., Olatunji, B.O., Persons, J.B., Rottenberg, J., Rozek, D.C., Schleider, J.L., Slavich, G.M., Teachman, B.A., Vine, V.J., Weinstock, L.M. (in press).  Mental health and clinical psychological science in the time of COVID-19: Challenges, opportunities, and a call to action.  American Psychologist.

Hawes, M.T., Carlson, G.A., Finsaas, M.C., Olino, T.M., Seely, J.R., & Klein, D.N. (in press). Dimensions of irritability in adolescents: Longitudinal associations with psychopathology in adulthood. Psychological Medicine.

Kessel, E.M., Frost, A, Goldstein, B.L., Black, S.R., Dougherty, L.R., Carlson, G.A., & Klein, D.N. (in press). Developmental pathways from preschool irritability to multifinality in early adolescence: the role of diurnal cortisol. Psychological Medicine.

Kujawa, A., Arfer, K.B., Finsaas, M., Kessel, E.M., Mumper, E., & Klein, D.N. (in press). Mother–child relationship quality mediates the effects of maternal depression on neural reactivity to rejection feedback and peer stress in adolescence: A 9-year longitudinal study. Clinical Psychological Science.

Schramm, E., Klein, D.N., Elsaesser, M., Furukawa, T., & Domschke, K. (in press). Review of Persistent Depressive Disorder: History, correlates, and clinical implications. Lancet Psychiatry.

Finsaas, M.C., Kessel, E.M., Dougherty, L.R., Bufferd, S.J., Danzig, A.P., Davila, J., Carlson, G.A., & Klein, D.N. (2020). Early childhood psychopathology prospectively predicts social functioning in early adolescence. Journal of Clinical Child and Adolescent Psychology. 49, 353-364., 

Finsaas, M.C., Olino, T.M., Hawes, M., Mackin, D.M., & Klein, D.N. (2020). Psychometric analysis of the Adult Separation Anxiety Symptom Questionnaire: Item functioning and invariance across sex and time. Psychological Assessment, 32, 582-593.

Mumper, E.E., Dyson, M.W., Finsaas, M.C., Olino, T.M., & Klein, D.N. (2020). Life stress moderates the effects of preschool behavioral inhibition on anxiety in early adolescence.  Journal of Child Psychology and Psychiatry,  61, 167-174.    

Frost, A., Kessel, E., Black, S., Goldstein, B., Bernard, K., & Klein, D.N. (2019). Homotypic and heterotypic continuity of internalizing and externalizing symptoms from age 3 to age 12: The moderating role of diurnal cortisol. Development and Psychopathology, 31, 789-798.

Kessel, E.M., Nelson, B.D., Finsaas, M., Kujawa, A., Meyer, A., Bromet, E., Carlson, G.A., Hajcak, G., Kotov, R., & Klein, D.N. (2019). Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children. Development and Psychopathology, 31, 1589-1598.

Kujawa, A., Hajcak, G., & Klein, D.N. (2019). Reduced reward responsiveness moderates the effect of maternal depression on depressive symptoms in offspring: Evidence across levels of analysis. Journal of Child Psychology and Psychiatry, 60, 82-90.

Mackin, D.M., Kotov, R., Perlman, G., Nelson, B.D., Goldstein, B.L., Hajcak, G., & Klein, D.N. (2019). Reward processing and future life stress: Stress generation pathway to depression. Journal of Abnormal Psychology, 128, 305-314.

Michelini, G., Barch, D.M., Tian, Y., Watson, D., Klein, D.N., & Kotov, R. (2019). Delineating and validating higher-order dimensions of psychopathology in the Adolescent Brain Cognitive Development (ABCD) study. Translational Psychiatry, 9, 261.

Neilsen, J.D., Olino, T.M., Dyson, M.W., & Klein, D.N. (2019). Reactive and regulatory temperament: Longitudinal associations with internalizing and externalizing symptoms through childhood. Journal of Abnormal Child Psychology, 47, 1771-1784.

Pegg, S.L., Dickey, L.I., Mumper, E., Kessel, E., Klein, D.N., & Kujawa, A. (2019). Stability and change in emotional processing across development: A 6-year longitudinal investigation using event-related potentials. Psychophysiology.e13438.

Bufferd, S.J., Dougherty, L.R., Olino, T.M., Dyson, M.W., Carlson, G.A., & Klein, D.N. (2018). Temperament distinguishes persistent/recurrent from remitting anxiety disorders across early childhood. Journal of Clinical Child and Adolescent Psychology, 47, 1004-1013.

Finsaas, M.C., Bufferd, S.M., Dougherty, L.R., Carlson, G.A., & Klein, D.N. (2018). Preschool psychiatric disorders: Homotypic and heterotypic continuity through middle childhood and early adolescence. Psychological Medicine, 48, 2159-2168.

Goldstein, B.L., Kotov, R., Perlman, G., Watson, D., & Klein, D.N. (2018). Trait and facet-level predictors of first-onset depressive and anxiety disorders in a community sample of adolescent girls. Psychological Medicine, 48, 1282-1290.

Hausman, E. M., Kotov, R., Perlman, G., Hajcak, G., Kessel, E. M., & Klein, D. N. (2018). Prospective predictors of first-onset depressive disorders in adolescent females with anxiety disorders. Journal of Affective Disorders, 235, 176-183.

Kessel, E.M., Nelson, B.D., Kujawa, A., Hajcak, G., Bromet, E., Kotov, R., Carlson, G.A. & Klein, D.N. (2018). Hurricane Sandy-related stress exposure alters the development of neural reactivity to negative stimuli in children. Child Development, 89, 339-348.

Meyer, A., Nelson, B., Perlman, G., Klein, D.N., & Kotov, R. (2018). A neural biomarker, the error-related negativity, predicts the new onset of generalized anxiety disorder in a large sample of adolescent females. Journal of Child Psychology and Psychiatry, 59, 1162-1170.

Olino, T.M., Bufferd, S.J., Dougherty, L.R., Dyson, M.W., Carlson, G.A., & Klein, D.N.  (2018). The development of latent dimensions of psychopathology across early childhood: Stability of dimensions and moderators of change . Journal of Abnormal Child Psychology, 46, 1373-1384.

Current Research Support:

National Institute of Mental Health (RO1 MH 069942), "Temperamental emotionality in preschoolers and depression risk."
2004 - 2024. $7,289,330 (direct costs)
Principal Investigator (Co-Is: Gabrielle Carlson, Greg Hajcak, Joanne Davila, Thomas Olino)  

National Institute of Mental Health (R56 MH117116), “Gene expression and vulnerability to depression." 
2018-2020.  $940,865 (direct costs)
Multiple Principal Investigator with Roman Kotov

National Institute of Mental Health (RO1 MH118245 2019-2023), “Biopsychosocial mechanisms underlying internalizing psychopathology in a prospective population-based cohort of sexual minority young adults”.
2019-2023.  $113,180 (subcontract direct costs)
PI, subcontract, (PIs: Richard Branstrom, Mark Hatenbuehler, John Pachankis)

National Institute of Mental Health (RO1 MH 097767), “Trajectories of reward sensitivity and depression across adolescence”.
2018-2022. $2,588,487 (direct costs)
Co-Investigator (PI: Brady Nelson) 

National Institute of Occupational Safety and Health (U02 OH011321), “Personality-informed care model for 9/11-related comorbid conditions.”
2016-2021. $2,283,267 (direct costs)
Co-Investigator (PI: Roman Kotov) 

National Institute of Child Health and Development (R21 HD093912), “Using adolescent nonverbal behavior to predict aggression against bullies and bystanders”.
2018-2020. $275,000 (direct costs)
Co-Investigator, (PI: Johanna Jarcho)

Primary Mentor on Graduate Fellowship Awards:

National Science Foundation Graduate Research Fellowships to  Jamilah Silver