Daniel Klein, Ph.D.
State University of New York at Buffalo (1983) Distinguished Professor, Clinical Psychology
Dr. Klein plans to admit a new graduate student pending approval of funding.
Dr. Klein is interested in developmental psychopathology and adult psychopathology, particularly mood disorders in children, adolescents, and adults. His research explores the intergenerational transmission of depression; the roles of temperament and emotional reactivity, and early adversity in the development and course of mood disorders; the long-term course and continuity of mood disorders; the classification of mood disorders; comorbidity between depression and other disorders; and the psychotherapeutic and psychopharmacological treatment of depressive disorders.
Dr. Klein is currently directing a longitudinal study of the role of early temperament and emotional style in the development of later mood and anxiety disorders in a large community sample of children (the Stony Brook Temperament Study). The children were assessed at ages 3, 6, 9, 12, and 15; the age 18 assessment will begin in Fall, 2019. The study uses multiple measurement strategies to assess potential risk, protective, mediating, and moderating factors in multiple domains, including child emotional reactivity and regulation, psychopathology, psychophysiological and behavioral measures of processing of emotional information, polygenic risk scores, stress and pubertal hormones, parenting, environmental and family stress, stressful life events, and parental personality and psychopathology. In addition, resting state and task-related functional magnetic resonance imaging (fMRI) measures were collected on a subset of the larger sample. Together with Dr. Roman Kotov (Psychiatry), Dr. Klein is also directing a longitudinal study of a large sample of early adolescent girls who have been followed on six occasions to age 20 (the Adolescent Development of Emotions and Personality Traits study). This project also seeks to identify antecedents of, and pathways to, depressive disorders, and uses many of the same measures as the Stony Brook Temperament Study.
Selected Recent Publications:
Finsaas, M.C., Kessel, E.M., Dougherty, L.R., Bufferd, S.J., Danzig, A.P., Davila, J., Carlson, G.A., & Klein, D.N. (in press). Early childhood psychopathology prospectively predicts social functioning in early adolescence. Journal of Clinical Child and Adolescent Psychology.
Goldstein, B.L., Kessel, E.M., Kujawa, A., Finsaas, M.C., Davila, J., Hajcak, G., & Klein, D.N. (in press). Stressful life events moderate the effect of neural reward responsiveness in childhood on depressive symptoms in adolescence. Psychological Medicine.
Kessel, E.M., Nelson, B.D., Finsaas, M., Kujawa, A., Meyer, A., Bromet, E., Carlson, G.A., Hajcak, G., Kotov, R., & Klein, D.N. (in press). Parenting style moderates the effects of exposure to natural disaster-related stress on the neural development of reactivity to threat and reward in children. Development and Psychopathology.
Mumper, E.E., Dyson, M.W., Finsaas, M.C., Olino, T.M., & Klein, D.N. (in press). Life stress moderates the effects of preschool behavioral inhibition on anxiety in early adolescence. Journal of Child Psychology and Psychiatry .
Neilsen, J.D., Olino, T.M., Dyson, M.W., & Klein, D.N. (in press). Reactive and regulatory temperament: Longitudinal associations with internalizing and externalizing symptoms through childhood. Journal of Abnormal Child Psychology.
Frost, A., Kessel, E., Black, S., Goldstein, B., Bernard, K., & Klein, D.N. (in press). Homotypic and heterotypic continuity of internalizing and externalizing symptoms from age 3 to age 12: The moderating role of diurnal cortisol. Development and Psychopathology, 31, 789-798.
Kujawa, A., Hajcak, G., & Klein, D.N. (2019). Reduced reward responsiveness moderates the effect of maternal depression on depressive symptoms in offspring: Evidence across levels of analysis. Journal of Child Psychology and Psychiatry, 60, 82-90.
Mackin, D.M., Kotov, R., Perlman, G., Nelson, B.D., Goldstein, B.L., Hajcak, G., & Klein, D.N. (2019). Reward processing and future life stress: Stress generation pathway to depression. Journal of Abnormal Psychology, 128, 305-314.
Bufferd, S.J., Dougherty, L.R., Olino, T.M., Dyson, M.W., Carlson, G.A., & Klein, D.N. (2018). Temperament distinguishes persistent/recurrent from remitting anxiety disorders across early childhood. Journal of Clinical Child and Adolescent Psychology, 47, 1004-1013.
Dougherty, L.R., Klein, D.N., & Olino, T.M. (2018). Depression in children and adolescents (pp. 99-130). In J. Hunsley & E. Mash (Eds.), A Guide to Assessments that Work (2nd ed.). New York: Oxford University Press.
Finsaas, M.C., Bufferd, S.M., Dougherty, L.R., Carlson, G.A., & Klein, D.N. (2018). Preschool psychiatric disorders: Homotypic and heterotypic continuity through middle childhood and early adolescence. Psychological Medicine, 48, 2159-2168.
Goldstein, B.L., Kotov, R., Perlman, G., Watson, D., & Klein, D.N. (2018). Trait and facet-level predictors of first-onset depressive and anxiety disorders in a community sample of adolescent girls. Psychological Medicine, 48, 1282-1290.
Hausman, E. M., Kotov, R., Perlman, G., Hajcak, G., Kessel, E. M., & Klein, D. N. (2018). Prospective predictors of first-onset depressive disorders in adolescent females with anxiety disorders. Journal of Affective Disorders, 235, 176-183.
Kessel, E.M., Nelson, B.D., Kujawa, A., Hajcak, G., Bromet, E., Kotov, R., Carlson, G.A. & Klein, D.N. (2018). Hurricane Sandy-related stress exposure alters the development of neural reactivity to negative stimuli in children. Child Development, 89, 339-348.
McDonough-Caplan, H., Klein, D.N., & Beauchaine, T.P. (2018). Patterns of growth in depression and conduct problems from elementary school to adolescence among highly vulnerable children and their peers. Journal of Abnormal Psychology, 127, 326-337.
Meyer, A., Nelson, B., Perlman, G., Klein, D.N., & Kotov, R. (2018). A neural biomarker, the error-related negativity, predicts the new onset of generalized anxiety disorder in a large sample of adolescent females. Journal of Child Psychology and Psychiatry, 59, 1162-1170.
Olino, T.M., Bufferd, S.J., Dougherty, L.R., Dyson, M.W., Carlson, G.A., & Klein, D.N. (2018). The development of latent dimensions of psychopathology across early childhood: Stability of dimensions and moderators of change . Journal of Abnormal Child Psychology, 46, 1373-1384.
Current Research Support:
National Institute of Mental Health (RO1 MH 069942), "Temperamental emotionality in
preschoolers and depression risk."
2004 - 2024. $7,289,330 (direct costs)
Principal Investigator (Co-Is: Gabrielle Carlson, Greg Hajcak, Joanne Davila, Thomas Olino)
National Institute of Mental Health (R56 MH117116), “Gene expression and vulnerability
2018-2020. $940,865 (direct costs)
Multiple Principal Investigator with Roman Kotov
National Institute of Mental Health (RO1 MH118245 2019-2023), “Biopsychosocial mechanisms
underlying internalizing psychopathology in a prospective population-based cohort
of sexual minority young adults”.
2019-2023. $113,180 (subcontract direct costs)
PI, subcontract, (PIs: Richard Branstrom, Mark Hatenbuehler, John Pachankis)
National Institute of Mental Health (RO1 MH 097767), “Trajectories of reward sensitivity
and depression across adolescence”.
2018-2022. $2,588,487 (direct costs)
Co-Investigator (PI: Brady Nelson)
National Institute of Occupational Safety and Health (U02 OH011321), “Personality-informed
care model for 9/11-related comorbid conditions.”
2016-2021. $2,283,267 (direct costs)
Co-Investigator (PI: Roman Kotov)
National Institute of Child Health and Development (R21 HD093912), “Using adolescent
nonverbal behavior to predict aggression against bullies and bystanders”.
2018-2020. $275,000 (direct costs)
Co-Investigator, (PI: Johanna Jarcho)
National Institute of Mental Health (R21 MH111999), “Role of Top-down factors in threat
perception in anxiety”.
2017-2019. $275,000 (direct costs)
Co-Investigator (PI: Aprajita Mohanty)
Primary Mentor on Graduate Fellowship Awards:
National Institute of Mental Health Predoctoral National Research Service Award to Ellen M. Kessel
National Science Foundation Graduate Research Fellowships to Megan C. Finsaas and Jamilah Silver