Professor OjimaIwao Ojima, Distinguished Professor

Director, Institute of Chemical Biology and Drug Discovery
B.S., 1968, The University of Tokyo
M.S., 1970, The University of Tokyo
Ph.D. 1973, The University of Tokyo (Prof. Naoki Inamoto)

Phone: (631) 632-1339
Fax: (631) 632-7942
Email: iwao.ojima@stonybrook.edu
Publications    

 

 

  Credit: Iwao Ojima / CC-BY-SA 4.0

Appointments:

1973-1983 Senior  Research  Fellow and Group Leader, Sagami Institute of Chemical Research

1983     Associate Professor, Department of Chemistry, State University of New York at Stony Brook

1984     Professor, Department of Chemistry, State University of New York at Stony Brook

1989     Professeur invité, Université Claude Bernard Lyon I, Lyon, France

1991     Leading Professor, State University of New York at Stony Brook

1995     University Distinguished Professor, State University of New York

1996     Visiting Professor, The University of Tokyo, Tokyo, Japan

1997     Visiting Professor, The Scripps Research Institute, La Jolla, CA

1997     Professeur invité, Université de Paris XI, BIOCIS, Châtenay-Malabry, France

1997-2003 Chairman, Department of Chemistry, State University of New York at Stony Brook

2003-present, Director, Institute of Chemical Biology and Drug Discovery, Stony Brook.

2016-present, President, National Academy of Inventors Stony Brook University Chapter.

 

Award and Honors:

The 25th National Young Investigator Award ("Shimpo Sho"), The Chemical Society of Japan, 1976.

Arthur C. Cope Scholar Award, American Chemical Society, 1994.

The 51st Chemical Society of Japan Award (“Nihon Kagaku Kai Sho”) for distinguished achievements, The Chemical Society of Japan, 1999.

Emanuel B. Hershberg Award for Important Discoveries in Medicinally Active Substances, American Chemical Society, 2001.

Outstanding Inventor Award, The Research Foundation of the State University of New York, 2002.

NYSTAR Faculty Development Award, New York State Office of Science, Technology & Academic Research, 2002.

Inductee, American Chemical Society, Medicinal Chemistry Hall of Fame, 2006.

ACS Award for Creative Work in Fluorine Chemistry, American Chemical Society, 2013.

Ernest Guenther Award in the Chemistry of Natural Products, American Chemical Society, 2019.

 

Fellow, John Simon Guggenheim Memorial Foundation, 1995.

Fellow, American Association for the Advancement of Science, 1997.

Fellow, New York Academy of Sciences, 2000.

Fellow, American Chemical Society, “ACS Fellow”, 2010

Fellow, National Academy of Inventors, “NAI Fellow”, 2014.

 

William and Florence Catacosinos Professor in Cancer Research, Stony Brook Foundation, 1994.

Leading Professorship, State University of New York at Stony Brook, 1991

Distinguished Professorship, State University of New York, 1995

He was invited by the Royal Swedish Academy of Sciences to serve as a nominator for the Nobel prize in chemistry for the years 1990, 1996, 2002, and 2014.

Eli Lilly Lecturer, University of Kansas-Lawrence, 1990.

National Science Council Lecturer, Taiwan, 1990.

  1. Clarence Karcher Lecturer, The University of Oklahoma, 1992.

George Lesher Lecturer, Rensselaer Polytechnic Institute, 1995.

Boehringer-Ingelheim Distinguished Lecturer, Colorado State University, 1997.

Weissberger-Williams Lecturer, Eastman Kodak Co., 1997.

Dr. H. Martin Friedman University Lecturer, Rutgers, State University of New Jersey, 2001.

Bristol-Meyers Squibb Distinguished Lecturer, Colorado State University, 2002.

FMC Discovery Chemistry Lecturer, FMC Corporation, 2003.

  1. Clarence Karcher Lecturer, The University of Oklahoma, 2003.

Negishi-Brown Lecturer, Purdue University, 2007.

Ralph A. Raphael Lecturer, University of Glasgow, UK, 2008.

The Sosnovsky Distinguished Lectureship, University of Wisconsin Milwaukee, 2008.

Henry J. Shine Lecturer, Texas Tech University, 2009.

National Science Council Lecturer, Taiwan, 2011.

The Ohdang Lectureship Award, The Pharmaceutical Society of Korea, Korea, 2012.

Distinguished Lectureship in Medicinal Chemistry, University of Minnesota, 2013.

The Ji-Yu Guo Endowment Distinguished Lectureship, Institute of Chemistry and BioMedical Sciences, Nanjing University, 2015

SUSTech Chemical Sciences Lectureship, Southern University of Science and Technology, 2018

Professional Activities:

(Editor in Chief)

            Frontiers in Chemistry: Organic Chemistry (2017-)

(Senior Editor)

            Future Medicinal Chemistry (2008-)

(Guest Editor)

2006 Drug Resistant Tuberculosis: A Challenge in Chemotherapy, Curr. Topics Med. Chem.

2007 Modern Molecular Approaches to Drug Discovery, Acc. Chem. Res.

2007 Modern Natural Products Chemistry in Drug Discovery, J. Med. Chem.

2014    In-Silico Drug Design and In-Silico Screening, Molecules

2015    New Generation of Microtubule-Interacting Anticancer Agents, Molecules

(Advisory Board)

  1. Editorial Advisory Board of Journal of Molecular Catalysis (1986-1995)
  2. Editorial Advisory Board of Journal of Organic Chemistry (ACS) (1995-1999)
  3. Editorial Advisory Board of Organometallics (ACS) (1996-1998)
  4. Editorial Advisory Board of Current Topics in Medicinal Chemistry (2002-present)
  5. Editorial Advisory Board of Letters in Drug Design & Discovery (2003-present)
  6. Editorial Advisory Board of Medicinal Chemistry (2004-present)
  7. Editorial Advisory Board of Chem. Soc. Jpn (2005-present)
  8. Editorial Advisory Board of Anti-Cancer Agents in Medicinal Chemistry (2006-2015)
  9. Basic Science Advisory Board member, Stony Brook University Cancer Center (1999-2010).
  10. Stony Brook University Research Park Oversight Board (2007-2011).
  11. Cell in Motion – CiM, Cluster of Excellence, University of Muenster, Germany (2012-2017).
  12. Advisory Board member, Stony Brook Cancer Center (2014-presnet).

(Symposia and Conferences)

  1. Chairperson, The Stony Brook Symposium on Taxol and Taxotère, "New Hope for Breast Cancer Chemotherapy" Stony Brook, NY, May (1993).
  2. Chairperson, Symposium on "Recent Advances in the Chemistry of Taxane and Taxoid Anticancer Agents", 207th American Chemical Society National Meeting, San Diego, CA, March (1994).
  3. Chairperson, Symposium on "Fluoroamino Acids and Peptides in Medicinal Chemistry", 210th American Chemical Society National Meeting, Chicago, IL, August (1995).
  4. Organizer and Chairperson, Symposium on "New Prospects in Anticancer Agents for the 21st Century" 219th American Chemical Society National Meeting, San Francisco, CA, March (2000).
  5. Organizer, Ernest Guenther Award Symposium”, 219th American Chemical Society National Meeting, San Francisco, CA, March 2000.
  6. Organizer, Ernest Guenther Award Symposium, 229th American Chemical Society National Meeting, San Diego, CA, March (2005).
  7. Organizer, Symposium on “Drug Resistant Tuberculosis – Challenge in Chemotherapy”, 229th American Chemical Society National Meeting, San Diego, CA, March (2005).
  8. Organizer, ACS Award in Organometallic Chemistry Symposium, 231st American Chemical Society National Meeting, Atlanta, GA, March (2006).
  9. Organizer, “Modern Natural Products Chemistry and Drug Discovery” Symposium, 231st American Chemical Society National Meeting, Atlanta, GA, March (2006).
  10. Organizer, “Ernest Guenther Award Symposium, 233rd American Chemical Society National Meeting, Chicago, IL, March (2007).
  11. Organizer, “Modern Molecular Strategies for Tumor-Targeting Drug Delivery”, 234th American Chemical Society National Meeting, Boston, MA, August (2007)

(Advisory Committee, Panel Reviewer)

  1. Advisory Committee Member, NIH, Medicinal Chemistry (MCHA) Study Section (1988-1992).
  2. Ad Hoc Member, Triennial Oversight Committee, Chemistry Division, NSF (1992).
  3. Panel Reviewer, Basic Energy Science Program, U. S. Department of Energy (1992).
  4. Advisory Committee Member Reserve, NIH (1992-1995).
  5. Panel Reviewer, REU Program, Chemistry Division, NSF (1992).
  6. Panel Reviewer, NSF Postdoctoral Fellowship in Chemistry (1994).
  7. Chemistry and Related Sciences Special Emphasis Panel, NIH, Bioorganic and Natural Product Chemistry (BNP-1) Program (1995).
  8. Special Panel Reviewer, NIH, Medicinal Chemistry (MCHA) Study Section (1995).
  9. Chemistry and Related Sciences Special Emphasis Panel, NIH, Bioorganic and Natural Product Chemistry (BNP-1) Program (1996).
  10. Chemistry and Related Sciences Special Emphasis Panel, NIH, SBIR and STTR Programs (1996).
  11. Panel Reviewer, NSF Small Business Innovation Research (SBIR) Program (1997).
  12. Special Panel Reviewer, NIH, Medicinal Chemistry (MCHA) Study Section (1998).
  13. Special Panel Reviewer, NIH, Medicinal Chemistry (MCHA) Study Section (2001).
  14. Special Panel Reviewer, NIH, Bioorganic and Natural Product Chemistry (BNP) Study Section (2002).
  15. Panel Reviewer, NCI, Basic & Preclinical Subcommittee IRG (2002).
  16. Panel Reviewer, NCI, Basic & Preclinical Subcommittee IRG (2003).
  17. Panel Reviewer, NIH, Drug Discovery & Molecular Pharmacology (DMP) Study Section, Oncological Sciences IRG (2004).
  18. Panel Reviewer, NCI, National Cooperative Drug Discovery Groups for Cancer (NCDDG) IRG (2004).
  19. Special Emphasis Panel Reviewer, NCI, ONC-K Study Section (2005).
  20. Special Emphasis Panel Reviewer, NIH, BCMB-B Study Section (2005).
  21. Special Emphasis Panel Reviewer, NIH, BCMB-B Study Section (AIR, AED) (Feb. and July 2008)
  22. Panel Reviewer, NIH, Synthetic and Biological Chemistry A (SBCA) Study Section (June 2009)
  23. Special Emphasis Panel Reviewer, NIH Challenge Grant (June 2009)
  24. Panel Reviewer, NIH, SBIR/STTR Cancer Drug Development Study Section  (July 2009)
  25. Special Emphasis Panel Reviewer, NIH, BCMB-B Study Section (September 2010)
  26. Special Emphasis Panel Reviewer, NIH, NIAID Biodefense Study Section (October 2011)
  27. Panel Reviewer, NCI, SBIR Contract, Development of Anticancer Agents Study Section (March 2012)
  28. Special Emphasis Panel Reviewer, NIH, NIAID Biodefense Study Section (September 2012)
  29. Special Emphasis Panel Reviewer, NIH, NCI, SBIR Bridge Award Study Section (June 2013)
  30. Special Emphasis Panel Reviewer, NIH, NIAID, CETR Study Section (July/September 2013)
  31. Special Emphasis Panel Reviewer, NIH, NCI, OTC Cancer Therapeutics Study Section (January 2014)
  32. Research Grants Council of Hong Kong (May 2015)
  33. Reviewer, Defense Threat Reduction Agency (DTRA), Fundamental Research to Counter Weapons of Mass Destruction Program (October 2015)
  34. Reviewer, Research Council of Norway (October 2015)
  35. Reviewer, Oakridge Associated Universities, Florida Department of Health (December 2015)
  36. Reviewer, Japan Society for Promotion of Science (JSPS) (February 2016)
  37. Reviewer, Defense Threat Reduction Agency (DTRA), Fundamental Research to Counter Weapons of Mass Destruction Program (May 2016)
  38. Reviewer, Cottrell Award, Research Corporation for Science Advancement (October 2016)
  39. Reviewer, Oakridge Associated Universities, Florida Department of Health (December 2016)
  40. Reviewer, NIH REACH Program, Stony Brook University (November 2016)
  41. The Welcome Trust DBT Fellowship Program (August, 2017)
  42. Reviewer, Oakridge Associated Universities, Florida Department of Health (December 2017)
  43. Reviewer, Oakridge Associated Universities, Pennsylvania Department of Health (December 2017)

(American Chemical Society)

  1. Executive Committee Member, Division of Organic Chemistry, American Chemical Society (1998-2001).
  2. Long Range Planning Committee, Division of Medicinal Chemistry, American Chemical Society (2003-2006).

 

 

Consulting:

         He has served as a consultant for E. I. du Pont, Eli Lilly, Air Products & Chemicals, Mitsubishi Chem. Corp, Nippon Steel Corp. Life Science Division, Rhone-Poulenc Rorer, ImmunoGen, Inc., Taiho Pharmaceutical Co., Milliken & Co., Aventis Pharma, OSI Pharmaceuticals, Inc., INDENA, SpA, Day Casebeer LLP, Fujian Yew Park Biological Co., Ltd., ChemMaster International, Central Glass Co., Fitzpatrick, Cella, Harper & Scinto, Quinn Emanuel Urquhart & Sullivan, LLP, Ajinomoto Co., Inc., Tayler Wessing LLP, Guidepoint Global Advisors.

 Memberships

      He is a member of American Chemical Society, American Association for the Advancement of Science, American Association for Cancer Research, American Peptide Society, New York Academy of Sciences, Sigma Xi, The Chemical Society of Japan, and The Society of Synthetic Organic Chemistry, Japan.

Research Interest and Activities:  

      His research interests include drug design and discovery (anticancer agents, antibacterial agents, enzyme inhibitors), medicinal chemistry and chemical biology, catalytic asymmetric synthesis, organic synthesis by means of organometallic reagents and catalysts, homogeneous catalysis and organometallic chemistry, peptide and peptidomimetics, b-lactam chemistry, and organofluorine chemistry (fluoroamino acids and peptides, fluorotaxoids, medicinal applications).  He has published more than 480 papers and reviews in leading journals and more than l00 patents granted, edited 9 books, and he has given more than 135 Plenary and Invited Lectures in international conferences and symposia by March 2019.  SciFinder lists more than 1,000 publications to his credit. Google Scholar shows his h-index as 77 and total citation of >28,500 by March 2018.  He has also given numerous invited lectures at universities, research institutes, and industries (total >520 since his move to Stony Brook in 1983).

Educational Activity as Thesis and Research Advisor:

      He has advised 72 postdoctoral research associates/fellows, 124 graduate students (68 Ph.D. degrees and 36 M.S. degrees), 107 undergraduate research students, 15 visiting scientists, and 62 high school summer research students (most of them won Westinghouse, Intel, Regeneron and Siemens Science Competitions, including Grand Prize) by March 2019.

 

Selected Plenary and Invited Lectures in International Meetings since 2014 (Total 137):

  1. 4th International Symposium on Organofluorine Compounds in Biomedical, Materials and Agricultural Sciences, “Bordeaux Fluorine Days”, Bordeaux, July 6-10, 2014. “Strategic Incorporation of Fluorine into Novel Anti-TB Agents and Anticancer Drug Conjugates for Preclinical Drug Development”.
  2. 248th American Chemical Society National Meeting, San Francisco, CA, August 10-14, 2014. “New Generation Anti-TB Drug Discovery Targeting Mtb-FtsZ”.
  3. International Symposium of Chemistry and Life Sciences, Jiangyin China, October 16-17, 2014. “Tumor-Specific Guided Molecular Missiles for Next Generation Cancer Cheotherapy”.
  4. DFG-GRK “Fluorine as a Key Element” Workshop, Berlin, Germany, April 23-24, 2015. "Strategic Incorporation of Fluorine into Bioacitve Compounds for Medicinal Chemistry and Chemical Biology Studies - Part I"; "Strategic Incorporation of Fluorine into Bioacitve Compounds for Medicinal Chemistry and Chemical Biology Studies - Part II".
  5. 21st International Symposium on Fluorine Chemistry, Como, Italy, August 23-28, 2015. “Strategic Incorporation of Fluorine into Novel Tumor-Targeting Drug Conjugates for Preclinical Development Using 19F NMR and PET imaging”.
  6. 5th International Symposium on Organofluorine Compounds in Biomedical, Organic Materials and Agriculture Sciences, “Bremen Fluorine Days”, Bremen, Germany, July 3-7, 2016. “Strategic Incorporation of Fluorine into Bioactive Compounds for Medicinal Chemistry and Chemical Biology Studies”.
  7. 23rd Winter Fluorine Conference, American Chemical Society, Clearwater, FL, January 15-20, 2017. “Strategic Incorporation of Fluorine into Bioactive Compounds for Chemical Biology and Drug Discovery”.
  8. 253rd American Chemical Society National Meeting, San Francisco, CA, April 2-6, 2017. “Strategic Incorporation of Fluorine into Bioactive Compounds for Medicinal Chemistry and Drug Discovery”.
  9. 17th International Symposium on Drug Delivery Systems, Prague, Czech Republic, July 12-14, 2017. “Next-Generation Taxane Anticancer Agents and Their Tumor-Targeted Delivery”.
  10. 6th International Symposium on Organofluorine Compounds in Biomedical, Organic Materials and Agriculture Sciences, “Nanjing Fluorine Days”, Nanjing, May 20-24, 2018. “Strategic Incorporation of Fluorine into Bioactive Compounds for Medicinal Chemistry and Chemical Biology Studies”.
  11. 22nd International Symposium on Fluorine Chemistry, Oxford, U.K., July 22-29, 2018. “Strategic Incorporation of Fluorine into Bioactive Compounds for Medicinal Chemistry, Chemical Biology and Drug Discovery”.
  12. 247th American Chemical Society National Meeting, Orlando, FL, March 31-April 4, 2019. ACS Fluorine Chemistry Award Symposium, “Strategic incorporation of fluorine into bioactive compounds for medicinal chemistry and drug discovery: A progress report”.
  13. 247th American Chemical Society National Meeting, Orlando, FL, March 31-April 4, 2019. Ernest Guenther Award Symposium, Award Address, “Exploration of the exceptional potential of taxane-class diterpenes at the interface of chemistry, biology and medicine”.

 

Invited Lectures Since 2014 (Total 523 since he moved to Stony Brook in 1983):

  1. Ecole Polytechnique, Université Paris-Saclay, Palaiseau, France [July 15, 2014, S. Zard]
  2. Gakushuin University, Department of Chemistry, Mejiro, Tokyo, Japan [September 24, 2014, T. Akiyama]
  3. Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan [September 25, 2014, Y. Hayashi]
  4. Ajinomoto Pharmaceuticals Co. Ltd., Pharmaceutical Research Center, Kawasaki, Japan [October 29, 2014, K. Sakurai]
  5. Central Glass Co., Ltd., Chemical Research Center, Kawagoe, Japan [October 30, 2014, T. Komata]
  6. Kitasato Institute and Kitasato University Graduate School, Sirogane, Tokyo, Japan [Nov. 5, 2014, T. Sunazuka]
  7. The University of Tokyo, Graduate School of Pharmaceutical Sciences, Hongo, Tokyo, Japan [Nov. 6, 2014, M. Kanai]
  8. Kyoto University, Department of Synthetic and Biological Chemistry, Katsura, Kyoto, Japan [Nov. 8, 2014, M. Murakami]
  9. Queens College – City University of New York, Department of Chemistry and Biochemistry, Queens, New York [March 16, 2015, H. Gafney, Y. Chen]
  10. Institute of Chemistry and BioMedical Sciences, Nanjing University, Nanjing, China [July 21, 2015, G. Li]
  11. Shanghai Jian-Tong University, School of Chemistry and Chemical Engineering, Shanghai, China [July 23, W. Zhang]
  12. Diichi Sankyo, Co. Ltd., Drug Discovery Chemistry Research Center, Shinagawa, Tokyo, Japan [Oct. 26, M. Nagamochi]
  13. Central Glass Co., Ltd., Chemical Research Center, Kawagoe, Japan [Oct. 29, 2015, M. Yasumoto]
  14. Ajinomoto Pharmaceuticals Co. Ltd., Pharmaceutical Research Center, Kawasaki, Japan [Oct. 30, 2015, M. Tokumasu]
  15. The University of Tokyo, Graduate School of Chemistry, Hongo, Tokyo, Japan [Nov. 6, 2015, H. Suga]
  16. RIKEN, Advanced Science Institute, Wako, Saitama, Japan [Oct. 18, 2016, M. Sodeoka]
  17. Kitasato Institute and Kitasato University Graduate School, Sirogane, Tokyo, Japan [Oct. 24, 2016, T. Sunazuka]
  18. Central Glass Co., Ltd., Chemical Research Center, Kawagoe, Japan [Oct. 27, 2016, A. Ishii]
  19. Ajinomoto, Co., Inc., Research Center, Kawasaki, Japan [Oct. 28, Y. Tanaka]
  20. The University of Tokyo, Graduate School of Applied Chemistry, Hongo, Tokyo, Japan [Nov. 2, 2016, M. Fujita]
  21. The Charles University, Third Faculty of Medicine, Prague, Czech Republic [July 13, 2017, J. Kovar]
  22. The Czech National Institutes of Public Health, Toxicology Unit, Prague, Czech Republic [July 17, 2017, P. Soucek]
  23. Selvita, S.A., Krakow, Poland [July 20, 2017, C. Commandeour]
  24. Tsukuba University, Tsukuba, Japan [October 25, 2017, J. Ichikawa]
  25. The University of Tokyo, Graduate School of Pharamaceutical Sciences, Hongo, Tokyo, Japan [October 27, 2017, T. Kanai]
  26. Ajinomoto Co. Inc., Central Research Center, Kawasaki, Japan [October 31, 2017, K. Ohsumi]
  27. Central Glass, Chemical Research Center, Kawagoe, Japan [November 2, 2017, A. Ishii]
  28. Guangzhou Institute for Biomedicine and Health (GIBH), Guangzhou Science City, Guangdong, China [January 8 and 10, 2018, M. Tortorella]
  29. Southern University of Science and Technology (SuSTech), Shenzhen, Guangdong, China [May 31, 2018, C.-C. Li]
  30. Manhattan College ACS, Bronx, NY [September 26, 2018, J. McCullagh, M. Skuriat]
  31. Central Glass, Chemical Research Center, Kawagoe, Japan [October 23, 2018, A. Ishii, T. Komata]
  32. Kitasato Institute for Life Sciences and Graduate School of Infection Control Sciences, Kitasatao University, Sirogane, Tokyo, Japan [Oct. 24, 2018, T. Sunazuka, S. Omura]
  33. The University of Tokyo, Department of Applied Chemistry, Hongo, Tokyo, Japan [October 25, 2018, M. Fujita]
  34. Ajinomoto Co. Inc., Innovation Research Center, Kawasaki, Japan [October 30, 2018, K. Ohsumi]
  35. The Friends of University of Tokyo, Manhattan, New York City, NY [March 16, 2019, M. Yamada]

 

In addition to these invited lectures, he and his laboratory members regularly present papers at the American Chemical Society's National Meetings, ACS Winter Fluorine Conference, American Association for Cancer Research (AACR) Annual Meeting.

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Professor Ojima
Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400 Phone: (631) 632-7890
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