Recent Publications

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  1. “Novel taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro potency and expression of angiogenesis genes”, B. Otová, I. Ojima, R. Václavíková, J. Hrdý, M. Ehrlichová, P. Souček, J. Vobořilová, V. Němcová, I. Zanardi, S. Horský, J. Kovář, and I. Gut, Invest. New Drugs 30, 991-1002 (2012). PMID: 21448670
  2. "Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents", S. Zheng, S. Y. R. Laxmi, E. David, A. Dinkova-Kostova, K. Shiavoni, Y. Ren, Y. Zheng, I. Trevino, R. Bumeister, I. Ojima, W. Wigley, J. Bliska, D. Mierke and T. Honda, J. Med. Chem. 55, 4837−4846 (2012). PMID: 22533790
  3. “Transport, metabolism, cytotoxicity and effects of novel taxanes on the cell cycle in MDA-MB-435 and NCI/ADR-RES cells”, M. Ehrlichová, I. Ojima, R. Václavíková, V. Němcová-Fürstová, J. Vobořilová, P. Šimek, S. Horský, P. Souček, J. Kovář, and I. Gut, Naunyn-Schmiedeberg’s Arch. Pharmacol. 385, 1035-1048 (2012) [Epub ahead of print, 8/2/2012]. PMID: 22855252
  4. “Synthesis and Biological Evaluation of Novel 3’-Difluorovinyl Taxoids”, L. Kuznetsova, L. Sun, J. Chen, X. Zhao, J. Seitz, M. Das, Y. Li, J. M. Veith, P. Pera, R. J. Bernacki, S. Xia, S. B. Horwitzand I. Ojima, J. Fluor. Chem. 143, 177-188 (2012). [Special Issue for ACS Award in Fluorine Chemistry: David O’Hagen]. PMC3489494
  5. “Targeting Fatty Acid Binding Protein (FABP) Anandamide Transport - A Novel Therapy for the Management of Pain and Inflammation”, W. T. Berger,B. P. Ralph, M. Kaczocha, J. Sun, T. E. Balius, R. C. Rizzo, S. Haj-Dahmane, I. Ojima, and D. G. Deutsch, PLOS ONE 7(12): e50968 (2012). PMC3517626
  6. Microwave-assisted Diels-Alder reactions between Danishefsky's diene and derivatives of ethyl 2-(hydroxymethyl)- acrylate. Synthetic approach towards a biotinylated anti-inflammatory monocyclic cyanoenone”, S. Zheng, A. Chowdhury, I. Ojima and T. Honda, Tetrahedron 69, 2052-2055 (2013).
  7. “Benzimidazole-Based Antibacterial Agents against F. tularensis”, K. Kumar, D. Awasthi, S.-Y. Lee, J. E. Cummings, S. E. Knudson, R. A. Slayden and I. Ojima, Bioorg. Med. Chem. 21, 3318-3326 (2013). PMC3681959
  8.  “Pd-catalyzed Asymmetric Allylic Etherification Using Chiral Biphenol-based Diphosphonite Ligands and Its Application for The Formal Total Synthesis of (-)-Galanthamine”, Y. Zang and I. Ojima, J. Org. Chem. 78, 4013-4018 (2013). PMID: 23472673
  9. “Caspase-2 is involved in cell death induction by taxanes in breast cancer cells”, M. Jelínek, K. Balušíková, J. Fidlerová, V. Němcová-Fürstová, D. Kopperová, J. Šrámek, I. Zanardi, I. Ojima and J. Kovář, Cancer Cell Int. 13(1):42 (2013). [Epub ahead of print: 5/15/2013] PMID: 23672670
  10. “Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl- 3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets”, A. Saito, M. Higgins, S. Zheng, W. Li, I. Ojima, A. T. Dinkova-Kostova, and T. Honda, Bioorg. Med. Chem. Lett. 23, 5540-5543 (2013). PMID: 24018193
  11. “Prostate cancer stem cell-targeted efficacy of a new generation taxoid, SBT-1214 and novel polyenolic zinc binding curcuminoid, CMC2.24”, G. I. Botchkina, E. S. Zuniga, R. Park, R. H. Rowehl, R. Bhalla, A. B. Bialkowska, Y. Zhang, F. Johnson, L. M. Golub, I. Ojima and K. R. Shroyer, PLoS ONE 8, e69884: 1-15 (2013). PMC3782470
  12. “An Improved Synthesis of a Hydroxymethyl Tricyclic Ketone from Cyclohexanone, the Key Processes for the Synthesis of a Highly Potent Anti-inflammatory and Cytoprotective Agent”, A. Saito, S. Zheng, M. Takahashi, W. Li, I. Ojima, and T. Honda, Synthesis, 45, 3251-3254 (2013).
  13. “SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of Mtb FtsZ for the Development of Novel Antitubercular Agents”,  D. Awasthi, K. Kumar, S. E. Knudson, R. A. Slayden and I. Ojima, J. Med. Chem. 56, 9756-9770 (2013). NIHMS544122
  14. “Crystallographic Study of FABP5 as an Intracellular Endocannabinoid Transporter”, B. Sanson, T. Wang, J. Sun, M. Kaczocha, I. Ojima, D. G. Deutsch, and H. Li, Acta Cryst., Section D (Biological Crystallography), 70, 290-298 (2014). PMC3976407
  15. Inexpensive chemical method for preparation of enantiomerically pure phenylalanine”, H. Moriwaki, D. Resch, H. Li, I. Ojima, R. Takeda, J. L. Aceña and V. Soloshonok, Amino Acids. 46, 945-952 (2014). PMID: 24385244
  16. Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with (R)-2-(N-{2-[N-alkyl-N-(1-phenylethyl)amino]acetyl}amino)benzophenone; a case of configurationally stable stereogenic nitrogen”, H. Moriwaki, D. Resch, H. Li, I. Ojima, R. Takeda, J. L. Aceña, V. A. Soloshonok,  Beilstein J. Org. Chem. 10, 442–448 (2014). PMC3943998
  17. “A Trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacteria tuberculosis”, S. E. Knudson, D. Awasthi, K. Kumar, A. Carreau, L. Goullieux, S. Lagrange, H. Vermet,I. Ojima, and R. A. Slayden, PLoS ONE 9(4):e93953 (2014). PMC3988029
  18. “Inhibition of Fatty Acid Binding Proteins Elevateds Brain Anandamide Levels and Produces Analgesia”, M. Kaczocha; M. J. Rebecchi, B. P Ralph, Y.-H. Gary Teng, W. T. Berger, W. Galbavy, M. W. Elmes, S. T. Glaser; L. Wang; R. C. Rizzo, D/ G. Deutsch and I. Ojima, PLoS ONE 9(4), e94200 (2014). PMC3976407
  19. “Design, Synthesis and Evaluation of Novel 2,5,6-Trisubstituted Benzimidazoles Targeting FtsZ as Antitubercular Agents”, B. Park, D. Awasthi, S. R. Chowdhury, E. Melief, K. Kumar, S. E. Knudson, R. A. Slayden and I. Ojima, Bioorg. Med. Chem. 22, 2602-2612 (2014). NIHMS581509
  20. “Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances”. R. Matesanz, C. Trigili, J. Rodríguez-Salarichs, I. Zanardi, B. Pera, A. Nogales, W.-S. Fang, J. Jímenez-Barbero, Á. Canales, I. Barasoain, I. Ojima and J. F. Díaz, Bioorg. Med. Chem. (Symposium-in-Print), 22,5078-5090 (2014). PMID: 25047938
  21. “Potency of benzimidazoles and in vitro activity–efficacy relationship against Mycobacteria tuberculosis”, S. E. Knudson, K. Kumar, D. Awasthi, I. Ojima and R. A. Slayden, Tuberculosis 94 (3),271-276 (2014). PMID: 24746463
  22. “SB-RA-2001 inhibits bacterial proliferation by targeting FtsZ assembly”, D. Singh, A. Bhattacharya, A. Rai, D. Awasthi, I. Ojima and D. Panda, Biochemistry 53 (18), 2979-2992 (2014). PMID: 24749867
  23. “Design, Synthesis and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid-Camptothecin Combination Chemotherapy”, J. G. Vineberg, E.  S. Zuniga, A. Kamath, Y.-J. Chen, J. D. Seitz, I. Ojima, J. Med. Chem. 57 (13), 5777-5791 (2014). PMC4096217
  24. "Establishment of Highly Tumorigenic Human Colorectal Cancer Cell Line (CR4) with Properties of Putative Cancer Stem Cells", R. A. Rowehl, S. Burke, A. Bialkowska, D. W. Pettet, III, L. Rowehl, E. Li; E. Antoniou, Y. Zhang, R. Bergamaski, K. R. Shroyer, I. Ojima and G. I. Botchkina, PLoS ONE, 9 (6), e99091 (2014). PMC4055451 
  25. “Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method”, S. Zheng, J. T. Huang, E. V. Knatko, S. Sharp, M. Higgins, I. Ojima, A. T. Dinkova-Kostova and T. Honda, J. Labelled Comp. Radiopharm. 57(10), 606-610. PMID: 25196444
  26.  “Design, Synthesis and Application of Fluorine-Labeled Taxoids as 19F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems”, J. D. Seitz, J. G.Vineberg, L. Wei, J. F. Khan,B. Lichtenthal, C.-F. Lin and I. Ojima, J. Fluor. Chem. 166 (2014) in press. DOI: 10.1016/j.jfluchem.2014.08.006; published online August 13, 2014. NIHMS623771
  27. “Enantioselective Pd-Catalyzed Tandem Allylic Alkylation Reaction Using Monodentate Phosphoramidite Ligands for the Formal Total Synthesis of Huperzine A”, C.-F. Lin, C.-W. Chien and I. Ojima, Org. Chem. Front. 1 (9), 1062-1066 (2014) [Max Malacria Special Issue].
  28. “Pd-Catalyzed Asymmetric Allylic Amination with BOP Ligands and Its Applications to the Synthesis of Fused polycyclic Alkaloids”, Y. Zang and I. Ojima, Tetrahedron Lett. Symposium-in-print (2015) [Harry H. Wasserman Memorial Issue]; 10.1016/j.tetlet.2015.01.047; published online (1/24/2015).
  29. “Design, Synthesis and Biological Evaluation of Theranostic Vitamin-Linker-Taxoid Conjugates”, J. G. Vineberg, T. Wang, E. S. Zuniga, and I. Ojima, J. Med. Chem. 58 (2015) in press.
  30. “The role of individual caspases in cell death induction by taxanes in breast cancer cells”,  M. Jelínek, K. Balušíková, M. Schmiedlová, V. Němcová-Fürstová,J. Šrámek, J. Chmelíková, I. Zanardi, I. Ojima and J. Kovář, Cancer Cell Int. (2015) in press.
  31. “Design, Synthesis and Biological Evaluation of a Highly-Potent and Cancer Cell Selective Folate-Taxoid Conjugate”, J. D. Seitz, J. G. Vineberg, E. Herlihy, B. Park, E. Melief, and I. Ojima, Bioorg. Med. Chem. (2015) submitted.
  1. “Tumor-targeting drug delivery of new generation taxoids”, I. Ojima, E. S. Zuniga, W. T. Berger, and J. D. Seitz, Future Med. Chem., 4, 33-50 (2012). PMC3282303
  2. “Strategic Incorporation of Fluorine into Taxoid Anticancer Agents”, A. Pepe, L. Sun and I. Ojima, In “Fluorine in Pharmaceutical and Medicinal Chemistry: From Biophysical Aspects to Clinical Applications" (V. Gouverneur and K. Müller Eds.), Oxford Univ. Press: Chapter 7, pp 209-240 (2012).
  3. “Advances in the chemistry of β-lactam and its medicinal applications”, A. Kamath and I. Ojima, Tetrahedron 68, 10640-10664 (2012). [Tetrahedron-Symposium-in-Print: Adavances in b-Lactam Chemistry] PMC3525065
  4.  “Advances in the Use of Enantiopure β-Lactams for the Synthesis of Biologically Active Compounds of Medicinal Interests”, I. Ojima, E. S. Zuniga and J. D. Seitz, Top. Heterocycl. Chem. 30, 1-64 (2012).
  5. “Exploration of Fluorine Chemistry at the Multidisciplinary Interface of Chemistry and Biology”, Ojima I. J Org Chem. 78, 6358-6383 (2013). PMC3752428
  6. “Fluorine-Containing Taxoid Anticancer Agents and Their Tumor-Targeted Drug Delivery”, J. Seitz, J. G.Vineberg, E. S. Zuniga, I. Ojima, J. Fluor. Chem. 152, 157-165 (2013). NIHMS485517
  7. “Organorhodium Chemistry”, I. Ojima, A. A. Athan, S. J. Chaterpaul, J. J. Kaloko, Y.-H. G. Teng, In “Organometalics in Synthesis, Fourh Mannual” (B. H. Lipshutz, Ed.), Wiley, Hoboken (2013); Chapter 2: pp135-318.
  8. “Taxol, Taxoids and Related Taxanes”, I. Ojima, A. Kamath and J. D. Seitz, In Natural Products in Medicinal Chemistry (S. Hanessian Ed.); Methods and Principles in Medicinal Chemistry, Vol. 60 (R. Mannhold, H. Kubinyi, G. Folkers, Eds.), Wiley-VCH, Weinheim (2013): pp127-180.
  9. “Chiral Ligands for Catalytic Asymmetric Synthesis”, A. A. Athan, W. Li, C.-F. Lin and I. Ojima, Kirk-Othmer Encyclopedia of Chemical Technology (A. Seidel Ed.), Wiley, Hoboken (2013). DOI: 10.1002/0471238961.chirojim.a01 (published online on July 19, 2013) 
  10. “Drug Discovery Targeting Cell Division Proteins, Microtubules and FtsZ”, I. Ojima, K. Kumar, D. Awasthi and J. G. Vineberg, Bioorg. Med. Chem. (Symposium-in-Print), 22,5060-5077 (2014). NIHMS 572845; PMID: 24680057
Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400 Phone: (631) 632-7890
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