Recent Publications

For a complete list of publications, please click here

Articles:
  • “Incarvillateine produces antinociceptive and motor suppressive effects via adenosine receptor activation”, Jinwoo Kim, Diane M. Bogdan, Matthew W. Elmes, Monaf Awwa, Su Yan, Joyce Che, Garam Lee, Dale G. Deutsch, Robert C. Rizzo, Martin Kaczocha and Iwao Ojima, PLoS ONE (2019) under revision.
  • “Synthesis of Colchicinoids and Allocolchicinoids through Rh(I)-catalyzed [2+2+2+1] and [2+2+2] Cycloadditions of o-Phenylenetriynes with and without CO”, J. Org. Chem. Chih-Wei Chien, Garry Yu-Han Teng, Tadashi Honda, Iwao Ojima, J. Org. Chem. 83, 11623-11644 (2018). PMID: 30129760
  • “Construction of Fused Tropone Systems Through Intramolecular Rh(I)-Catalyzed Carbonylative [2+2+2+1] Cycloadditon of Triynes”, Gary Y.-H. Teng, Chih-Wei Chien, Wen-Hua Chiou, Tadashi Honda and Iwao Ojima, Front. Chem. 6, 401 (2018). PMCID: 6139344
  • “SAR Studies on Truxillic Acid Mono Esters as a New Class of Antinociceptive Agents, Targeting Fatty Acid Binding Proteins”, Su Yan, Matthew W. Elmes, Simon Tong, Kongzhen Hu, Monaf Awwa, Gary Y. H. Teng, Yunrong Jing, Matthew Freitag, Qianwen Gan, Timothy Clement, Longfei Wei, Joseph M. Sweeney,  Olivia M. Joseph, Gregory S. Carbonetti, Liqun Wang, Jerome Falcone, Norbert Smietalo, Yuchen Zhou, Brian Ralph, Hao-Chi Hsu, Huilin Li, Robert C. Rizzo, Dale G. Deutsch, Martin Kaczocha and Iwao Ojima, Eur. J. Med. Chem., 154, 233-252 (2018). PMID: 29803996
  • “Substituents at the C3´ and C3´N positions are critical for taxanes to overcome acquired resistance of cancer cells to paclitaxel”, Michael Jelínek, Kamila Balušíková, Petr Daniel, Vlasta Němcová-Fürstová, Palani Kirubakaran, Jiří Vondrášek, Longfei Wei, Xin Wang, Iwao Ojima, Jan Kovář, Toxicol. Appl. Pharmacol. 347, 79-91 (2018). PMID: 29625142
  • "Design, Synthesis and Biological Evaluations of Asymmetric Bow-Tie PAMAM Dendrimer-based Conjugates for Tumor-Targeted Drug Delivery", Tao Wang, Yaozhong Zhang, Longfei Wei, Yuhan G. Teng, Tadashi Honda and Iwao Ojima, ACS Omega, 3(4), 3717–3736 (2018). PMC5928494
  • “Taxol® Analogues Exhibit Differential Effects on Photoaffinity Labeling of β-Tubulin and P-Glycoprotein”, Chia-Ping Huang Yang, Changwei Wang, Iwao Ojima, and Susan Band Horwitz, J. Nat. Prod. 81, 600-606 (2018). PMID: 29517223
  • “Acylhydrazones as antifungal agents targeting 1 the synthesis of fungal sphingolipids”, Cristina Lazzarinia, Krupanandan Haranahallic, Robert Riegerd, Hari Krishna Ananthulae, Pankaj B. Desaie, Alan Ashbaughf, Michael J. Linkef, Melanie T. Cushionf, Bela Ruzsicsk, John Haley, Iwao Ojima, and Maurizio Del Poeta, Antimicrob. Agents Chemother. 62(5), e00156-18 (2018). PMC5923120
  • "Synthesis of a Next-Generation Taxoid by Rapid Methylation Amenable for 11C-Labeling", Joshua D. Seitz, Tao Wang, Jacob G. Vineberg, Tadashi Honda and Iwao Ojima, J. Org. Chem. 83, 2847-2857 (2018). PMID: 29441783
  • “Fatty acid binding protein 5 controls microsomal prostaglandin E synthase 1 (mPGES-1) induction during inflammation”, Diane Bogdan, Jerome Falcone, Martha Patricia Kanjiya, Sang Hoon Park, Gregory Carbonetti, Keith Studholme, Maria Gomez, Yong Lu, Matthew Elmes, Norbert Smietalo, Su Yan, Iwao Ojima, Michelino Puopolo, and Martin Kaczocha, J. Biol. Chem. 293(14), 5295-5306 (2018). PMID: 29440395
  • “Biodistribution and Pharmacokinetic Evaluations of a Novel Taxoid DHA-SBT-1214 in an Oil-in-Water Nanoemulsion Formulation in Naïve and Tumor-Bearing Mice”, Gulzar Ahmad, Florence Gattacecca, Galina Botchkina, Iwao Ojima, James Egan, and Mansoor Amiji, Pharm. Res. 35, 91 (2018). PMID: 29520477
  • “Contribution of Diacylglycerol Lipase β To Pain After Surgery”, J. Luk, Y. Lu, A. Ackermann, X. Peng, D/ Bogdan, M. Puopolo, D. Komatsu, S. Tong, I. Ojima, M. J. Rebecchi, and M. Kaczocha, J. Pain Res. 11, 473-482 (2018). PMC5842774
  • “Design and synthesis of tumor-targeting theranostic drug conjugates for PECT and PET imaging studies”, Tao Wang, Jacob G. Vineberg, Tadashi Honda and Iwao Ojima, Bioorg. Chem. 76, 458-467 (2018). PMID: 29287255
  • “Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions”, Vincent M. Alford, Anushree Kamath, Xiaodong Ren, Kunal Kumar, Qianwen Gan, Monaf Awwa, Michael Tong, Markus Seeliger, Jian Cao, Iwao Ojima, Nicole S. Sampson, ACS Chem. Biol. 12(11), 2788-2803 (2017). PMID: 28945333
  • “Computational Design and Synthesis of Novel Fluoro-Analogs of Combretastatins A-4 and A-1”, Y. Zong, C. Shea, K. Maffucci and I. Ojima, J. Fluorine Chem. 203, 193-199 (2017). PMC5755605
  • “Nanoemulsion Formulation of a Novel Taxoid Prodrug SBT-1214 Conjugated with Omega-3 Fatty Acid Inhibits Prostate Cancer Stem Cell-Induced Tumor Growth”, G. Ahmad, R. El-Sadda, G. Botchkina, I. Ojima, J. Egan, and M. M. Amiji, Cancer Lett., 406, 71-80 (2017). PMID: 28803993
  • “The anti-nociceptive agent SBFI-26 binds to anandamide transporters FABP5 and FABP7 at two different sites”, H.-C. Hsu, S. Tong, Y. Zhou, M. Elmes, S. Yan, M. Kaczocha, D. G Deutsch, R. C Rizzo, I. Ojima, and H. Li, Biochemistry 56(27) 3454-3462 (2017). PMID: 28632393; PMC5884075
  • “Differing mechanisms of death induction by fluorinated taxane SB-T-12854 in breast cancer cells”, M. Jelínek, A. Kábelová, J. Šrámek, J. Seitz, I. Ojima, J. Kovář, Anticancer Res. 37, 1581-1590 (2017). PMID:28373418
  • “SB-T-121205, a next-generation taxane, enhances apoptosis and inhibits migration/invasion in MCF-7/PTX cells”, X. Zheng, C. Wang, Y. Xing, S. Chen, T. Meng, H. You, I. Ojima and Y. Dong, Int. J. Oncol. 50(3), 893-902 (2017). PMID: 28197640
  • “Fatty acid binding protein inhibition produces analgesic effects through peripheral and central mechanisms”, X. Peng, K. Studholme, M. P. Kanjiya, J. Luk, D. Bogdan, M. W Elmes, G. Carbonetti, S. Tong, Y.-H. G. Teng, R. C Rizzo, H. Li, D. G. Deutsch, I. Ojima, M. J. Rebecchi, M. Puopolo, and M. Kaczocha, Mol. Pain, 13, 1-16 (2017). PMC5407663
  • "Hedgehog pathway overexpression in pancreatic cancer is abrogated by new generation taxoid SB-T-1216", B. Mohelnikova-Duchonova, M. Kocik, B. Duchonova, V. Brynychova, M. Oliverius, J. Hlavsa, E. Honsova, J. Mazanec, Z. Kala, I. Ojima, D. Hughes, J. Doherty, H. Murray, M. Crawford, R. Lemstrova, and P. Soucek, Pharmacogenomics J. 17, 452–460 (2017). PMID: 27573236 
  • “Hydrogel microstructure live-cell array for multiplexed analyses of cancer stem cells, tumor heterogeneity and differential drug response at single-element resolution”, E. Afrimzon, G. Botchkina, N. Zurgil. Y. Shafran, M. Sobolev, S. Moshkov, O. Ravid-Hermesh, I. Ojima, M. Deutsch, Lab Chip, 16(6), 1047-1062 (2016).
  • "Identification of Small Molecule Inhibitors of Botulinum Neurotoxin Serotype E via Footprint Similarity", Y. Zhou, B. E. McGillick, Y.-H. G. Teng, K. Haranahalli, I. Ojima, S. Swaminathan, and R. C. Rizzo, Bioorg. Med. Chem. 24 4875-4889 (2016). PMID: 27543389
  • “Cell division inhibitors with efficacy equivalent to isoniazid in the murine model of Mycobacterium tuberculosis infection”, S. E. Knudson, D. Awasthi, K. Kumar, A. Carreau, L. Goullieux, S. Lagrange, H. Vermet, I. Ojima, and R. A. Slayden, J. Antimicrob. Chemother. 70, 3070-3073 (2015). PMC4613742.
  • “Computer-Aided Identification, Synthesis, and Biological Evaluation of Novel Inhibitors for Botulinum Neurotoxin Serotype A”, Y. H. Teng, W. T. Berger, N. M. Nesbitt, K. Kumar, T. E. Balius, R. C. Rizzo, P. J. Tonge, I. Ojima, and S. Swaminathan, Bioorg. Med. Chem. 23, 5489-5495 (2015). PMID: 26275678
  • “Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids”, V. Mor, A. Rella, A. Singh, A. M. Farnoud, M. Munshi, A. Bryan, S. Naseem, J. Konopka, I. Ojima, E. Bullesbach, A. Ashbaugh, M. J. Linke, M. Cushion, H. K. Ananthula, P. B. Desai, N. Wiederhold, A. W. Fothergill, W. Kirkpatrick, T. Patterson, C. Nislow, X. Pan, N. R. Movva, G. V. Cesar, S. Frases, K. Miranda, M. L. Rodrigues, C. Luberto, L. Nimrichter and M. Del Poeta, mBio, 6, e00647-15 (2015). PMC4479701
  • "New Monocyclic, Bicyclic, and Tricyclic Ethynylcyanodienones as Activators of the Keap1/Nrf2/ARE Pathway and Inhibitors of Inducible Nitric Oxide Synthase", Li, W.; Zheng, S.; Higgins, M.; Morra, R.; Mendis, A.; Chien, C.-W.; Ojima, I.; Mierke, D.; Dinkova-Kostova, A.; Honda, T., J. Med. Chem. 58, 4738−4748 (2015). PMID: 25965897
  • “High Capacity Poly(2-oxazoline) Micelles for 3rd Generation Taxoids: preparation, in vitro and in vivo evaluation”, Z. He, A. Schulz, X. Wan, J. Seitz, H. Bludau, D. B. Darr, C. M. Perou, R. Jordan, I. Ojima, A. V. Kabanov, R. Luxenhofer, J. Control. Release 208, 67-75 (2015). PMID: 25725361 
  • “Design, Synthesis and Biological Evaluation of a Highly-Potent and Cancer Cell Selective Folate-Taxoid Conjugate”, J. D. Seitz, J. G. Vineberg, E. Herlihy, B. Park, E. Melief, and I. Ojima, Bioorg. Med. Chem. 23 2187-2194 (2015). PMC4398638.
  • “The role of individual caspases in cell death induction by taxanes in breast cancer cells”, M. Jelínek, K. Balušíková, M. Schmiedlová, V. Němcová-Fürstová, J. Šrámek, J. Chmelíková, I. Zanardi, I. Ojima and J. Kovář, Cancer Cell Int. 15, 1-26 (2015). PMID: 25685064
  • “Fatty Acid Binding Proteins (FABPs) are Intracellular Carriers for Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD)”, M. W. Elmes, M. Kaczocha, W. T. Berger , K. Leung, B. P. Ralph, L. Wang, J. M. Sweeney, J. T. Miyauchi, S. E. Tsirka, I. Ojima and D. G. Deutsch, J. Biol. Chem. 290, 8711-8721 (2015). PMID: 25666611
  • “Design, Synthesis and Biological Evaluation of Theranostic Vitamin-Linker-Taxoid Conjugates”, J. G. Vineberg, T. Wang, E. S. Zuniga, and I. Ojima, J. Med. Chem. 58, 2406–2416 (2015). PMC4359053
  • “Pd-Catalyzed Asymmetric Allylic Amination with BOP Ligands and Its Applications to the Synthesis of Fused polycyclic Alkaloids”, Y. Zang and I. Ojima, Tetrahedron Lett. 56, 3288-3292 (2015) [Harry H. Wasserman Memorial Issue; Symposium-in-print].
  • “Design, Synthesis and Application of Fluorine-Labeled Taxoids as 19F NMR Probes for the Metabolic Stability Assessment of Tumor-Targeted Drug Delivery Systems”, J. D. Seitz, J. G.Vineberg, L. Wei, J. F. Khan, B. Lichtenthal, C.-F. Lin and I. Ojima, J. Fluor. Chem. 171, 148–161 (2015). PMC4337250
  • “Enantioselective Pd-Catalyzed Tandem Allylic Alkylation Reaction Using Monodentate Phosphoramidite Ligands for the Formal Total Synthesis of Huperzine A”, C.-F. Lin, C.-W. Chien and I. Ojima, Org. Chem. Front. 1 (9), 1062-1066 (2014) [Max Malacria Special Issue].
  • “Synthesis of (13) C2 (15) N2 -labeled anti-inflammatory and cytoprotective tricyclic bis(cyanoenone) ([(13) C2 (15) N2 ]-TBE-31) as an internal standard for quantification by stable isotope dilution LC-MS method”, S. Zheng, J. T. Huang, E. V. Knatko, S. Sharp, M. Higgins, I. Ojima, A. T. Dinkova-Kostova and T. Honda, J. Labelled Comp. Radiopharm. 57(10), 606-610 (2014). PMID: 25196444
  • "Establishment of Highly Tumorigenic Human Colorectal Cancer Cell Line (CR4) with Properties of Putative Cancer Stem Cells", R. A. Rowehl, S. Burke, A. Bialkowska, D. W. Pettet, III, L. Rowehl, E. Li; E. Antoniou, Y. Zhang, R. Bergamaski, K. R. Shroyer, I. Ojima and G. I. Botchkina, PLoS ONE, 9 (6), e99091 (2014). PMC4055451
  • “Design, Synthesis and Biological Evaluations of Tumor-Targeting Dual-Warhead Conjugates for a Taxoid-Camptothecin Combination Chemotherapy”, J. G. Vineberg, E. S. Zuniga, A. Kamath, Y.-J. Chen, J. D. Seitz, I. Ojima, J. Med. Chem. 57 (13), 5777-5791 (2014). PMC4096217
  • “SB-RA-2001 inhibits bacterial proliferation by targeting FtsZ assembly”, D. Singh, A. Bhattacharya, A. Rai, D. Awasthi, I. Ojima and D. Panda, Biochemistry 53 (18), 2979-2992 (2014). PMC4020581
  • “In vitro-in vivo activity relationship of substituted benzimidazole cell division inhibitors with activity against Mycobacterium tuberculosis”, S. E. Knudson, K. Kumar, D. Awasthi, I. Ojima and R. A. Slayden, Tuberculosis 94 (3),271-276 (2014). PMC4068151
  • “Taxanes with high potency inducing tubulin assembly overcome tumoural cell resistances”. R. Matesanz, C. Trigili, J. Rodríguez-Salarichs, I. Zanardi, B. Pera, A. Nogales, W.-S. Fang, J. Jímenez-Barbero, Á. Canales, I. Barasoain, I. Ojima and J. F. Díaz, Bioorg. Med. Chem. (Symposium-in-Print), 22, 5078-5090 (2014). PMID: 25047938
  • “Design, Synthesis and Evaluation of Novel 2,5,6-Trisubstituted Benzimidazoles Targeting FtsZ as Antitubercular Agents”, B. Park, D. Awasthi, S. R. Chowdhury, E. Melief, K. Kumar, S. E. Knudson, R. A. Slayden and I. Ojima, Bioorg. Med. Chem. 22, 2602-2612 (2014). PMC4045703
  • “Inhibition of Fatty Acid Binding Proteins Elevates Brain Anandamide Levels and Produces Analgesia”, M. Kaczocha; M. J. Rebecchi, B. P Ralph, Y.-H. Gary Teng, W. T. Berger, W. Galbavy, M. W. Elmes, S. T. Glaser; L. Wang; R. C. Rizzo, D/ G. Deutsch and I. Ojima, PLoS ONE 9(4), e94200 (2014). PMC3976407
  • “A Trisubstituted benzimidazole cell division inhibitor with efficacy against Mycobacteria tuberculosis”, S. E. Knudson, D. Awasthi, K. Kumar, A. Carreau, L. Goullieux, S. Lagrange, H. Vermet, I. Ojima, and R. A. Slayden, PLoS ONE 9(4):e93953 (2014). PMC3988029
  • “Synthesis and stereochemical assignments of diastereomeric Ni(II) complexes of glycine Schiff base with (R)-2-(N-{2-[N-alkyl-N-(1-phenylethyl)amino]acetyl}amino)benzophenone; a case of configurationally stable stereogenic nitrogen”, H. Moriwaki, D. Resch, H. Li, I. Ojima, R. Takeda, J. L. Aceña, V. A. Soloshonok, Beilstein J. Org. Chem. 10, 442–448 (2014). PMC3943998
  • “Inexpensive chemical method for preparation of enantiomerically pure phenylalanine”, H. Moriwaki, D. Resch, H. Li, I. Ojima, R. Takeda, J. L. Aceña and V. Soloshonok, Amino Acids. 46, 945-952 (2014). PMID: 24385244
  • “Crystallographic Study of FABP5 as an Intracellular Endocannabinoid Transporter”, B. Sanson, T. Wang, J. Sun, M. Kaczocha, I. Ojima, D. G. Deutsch, and H. Li, Acta Cryst., Section D (Biological Crystallography), 70, 290-298 (2014). PMC3976407
  • “SAR Studies on Trisubstituted Benzimidazoles as Inhibitors of Mtb FtsZ for the Development of Novel Antitubercular Agents”, D. Awasthi, K. Kumar, S. E. Knudson, R. A. Slayden and I. Ojima, J. Med. Chem. 56, 9756-9770 (2013). PMC3933301
  • “An Improved Synthesis of a Hydroxymethyl Tricyclic Ketone from Cyclohexanone, the Key Processes for the Synthesis of a Highly Potent Anti-inflammatory and Cytoprotective Agent”, A. Saito, S. Zheng, M. Takahashi, W. Li, I. Ojima, and T. Honda, Synthesis, 45, 3251-3254 (2013).
  • “Prostate cancer stem cell-targeted efficacy of a new generation taxoid, SBT-1214 and novel polyenolic zinc binding curcuminoid, CMC2.24”, G. I. Botchkina, E. S. Zuniga, R. Park, R. H. Rowehl, R. Bhalla, A. B. Bialkowska, Y. Zhang, F. Johnson, L. M. Golub, I. Ojima and K. R. Shroyer, PLoS ONE 8, e69884: 1-15 (2013). PMC3782470
  • “Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl- 3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets”, A. Saito, M. Higgins, S. Zheng, W. Li, I. Ojima, A. T. Dinkova-Kostova, and T. Honda, Bioorg. Med. Chem. Lett. 23, 5540-5543 (2013). PMID: 24018193
  • “Caspase-2 is involved in cell death induction by taxanes in breast cancer cells”, M. Jelínek, K. Balušíková, J. Fidlerová, V. Němcová-Fürstová, D. Kopperová, J. Šrámek, I. Zanardi, I. Ojima and J. Kovář, Cancer Cell Int. 13(1):42 (2013). PMC3685568
  • “Pd-catalyzed Asymmetric Allylic Etherification Using Chiral Biphenol-based Diphosphonite Ligands and Its Application for The Formal Total Synthesis of (-)-Galanthamine”, Y. Zang and I. Ojima, J. Org. Chem. 78, 4013-4018 (2013). PMID: 23472673
  • “Benzimidazole-Based Antibacterial Agents against F. tularensis”, K. Kumar, D. Awasthi, S.-Y. Lee, J. E. Cummings, S. E. Knudson, R. A. Slayden and I. Ojima, Bioorg. Med. Chem. 21, 3318-3326 (2013). PMC3681959
  • Microwave-assisted Diels-Alder reactions between Danishefsky's diene and derivatives of ethyl 2-(hydroxymethyl)- acrylate. Synthetic approach towards a biotinylated anti-inflammatory monocyclic cyanoenone”, S. Zheng, A. Chowdhury, I. Ojima and T. Honda, Tetrahedron 69, 2052-2055 (2013).

 

Reviews:
  • “Recent progress in the strategic incorporation of fluorine into medicinally active compounds”, Krupanandan Haranahalli, Tadashi Honda and  Iwao Ojima, J. Fluorine Chem. 217, 29–40 (2018). NIHMSID: NIHMS1513005
  • “Case Studies of Fluorine in Drug Discovery”, Li Xing, Tadashi Honda, Lori Fitz, and Iwao Ojima, In Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals (G. Haufe, F. Leroux Eds.), Progress in Fluorine Science Ser. (A. Tressard, Ed.), Academic Press; Elsevier, London (2018); Chapter 4; pp. 181-211; ISBN: 978-0-12-812733-9.
  • “Quest for Efficacious Next-Generation Taxoid Anticancer Agents and Their Tumor-Targeted Delivery”, Iwao Ojima, Xin Wang, Yunrong Jin and Changwei Wang, J. Nat. Prod. 81, 703-721 (2018) (ACS Editor’s Choice Article); PMC5869464
  • “Great Challenges in Organic Chemistry”. I. Ojima, Front Chem. 5, 52 (2017). doi: 10.3389/fchem.2017.00052. PMC5506087
  • “Strategic Incorporation of Fluorine into Taxoid Anticancer Agents for Medicinal Chemistry and Chemical Biology Studies”, I. Ojima, J. Fluorine Chem. 198, 10-23 (2017). [Bremen Fluorine Days Special Issue]. PMC5560435
  • “Drug resistance mechanisms and novel drug targets for tuberculosis therapy”, M. M. Islam , H. M. A. Hameed , J. Mugweru , C. Chhotaray , C. Wang, Y. Tan , J. Liu , X. Li , S. Tan , I. Ojima , W. W. Yew , E. Nuermberger, G. Lamichhane , T. Zhang, J. Genet. Genomics, 44, 21-37 (2017). PMID: 28117224
  • “Strategic Incorporation of Fluorine in the Drug Discovery of New-Generation Antitubercular Agents Targeting Bacterial Cell Division Protein FtsZ”, I. Ojima, D. Awasthi, L. Wei, K. Haranahalli, J. Fluorine Chem. 196, 44-56 (2017). [ACS Award Special Issue for Steven H. Strauss]. PMC544592
  • “Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ”, K. Haranahali, S. Tong, and I. Ojima, Bioorg. Med. Chem. 24, 6354–6369 (2016). [Symposium-in-Print “Novel Discoveries in Antibacterials] PMID: 27189886; PMC5157688.
  • “Strategic Incorporation of Fluorine for Drug Discovery and Development”, T. Honda and I. Ojima, In Modern Synthesis Processes and Reactivity of Fluorinated Compounds (H. Groult, F. Leroux, A. Tressaud, Eds.), Elsevier, (2016); Chapter 17; pp. 449-531; ISBN: 9780128037409; e-Book ISBN: 9780128037904.
  • “Taxane anticancer agents: a patent perspective”, I. Ojima, B. Lichtenthal, S. Lee, C. Wang and X. Wang, Expert Opin. Ther. Patents, 26, 1-20 (2016). PMC4941984
  • “Drug Discovery Targeting Cell Division Proteins, Microtubules and FtsZ”, I. Ojima, K. Kumar, D. Awasthi and J. G. Vineberg, Bioorg. Med. Chem. (Symposium-in-Print), 22, 5060-5077 (2014). PMC4156572
  • “Amidocarbonylation, Cyclohydrocarbonylation, and Related Reactions: Comprehensive Organometallic Chemistry III Update”, A. A. Athan and I. Ojima, In Chemistry, Molecular Sciences and Engineering (J. Reedijk Ed.), Elsevier, Waltham (2013). http://dx.doi.org/10.1016/B978-0-12-409547-2.03980-9 (published online on August 16, 2013)
  • “Chiral Ligands for Catalytic Asymmetric Synthesis”, A. A. Athan, W. Li, C.-F. Lin and I. Ojima, Kirk-Othmer Encyclopedia of Chemical Technology (A. Seidel Ed.), Wiley, Hoboken (2013). DOI: 10.1002/0471238961.chirojim.a01 (published online on July 19, 2013)
  • “Taxol, Taxoids and Related Taxanes”, I. Ojima, A. Kamath and J. D. Seitz, In Natural Products in Medicinal Chemistry (S. Hanessian Ed.); Methods and Principles in Medicinal Chemistry, Vol. 60 (R. Mannhold, H. Kubinyi, G. Folkers, Eds.), Wiley-VCH, Weinheim (2013): pp127-180.
  • “Organorhodium Chemistry”, I. Ojima, A. A. Athan, S. J. Chaterpaul, J. J. Kaloko, Y.-H. G. Teng, In “Organometalics in Synthesis, Fourh Mannual” (B. H. Lipshutz, Ed.), Wiley, Hoboken (2013); Chapter 2: pp135-318.
  • “Fluorine-Containing Taxoid Anticancer Agents and Their Tumor-Targeted Drug Delivery”, J. Seitz, J. G.Vineberg, E. S. Zuniga, I. Ojima, J. Fluor. Chem. 152, 157-165 (2013). PMC3735225
  • “Exploration of Fluorine Chemistry at the Multidisciplinary Interface of Chemistry and Biology”, Ojima I. J Org Chem. 78, 6358-6383 (2013). PMC3752428
Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400 Phone: (631) 632-7890
Login to Edit