Faculty
Department of Anesthesiology
Martin Kaczocha
Role of fatty acid binding proteins in pain, inflammation, and related pathophysiologies:
Endocannabinoid pharmacology and development of novel therapeutics.
Department of Biochemistry and Cell Biology
Michael Airola, Structural biology of lipid modifying enzymes
Nurit Ballas, The cellular and molecular mechanisms underlying the autism spectrum disorder Rett Syndrome
Paul M. Bingham, Genetic control of development and gene expression in animals
Deborah Brown Cholesterol/sphingolipid-rich domains in membrane signaling
Vitaly Citovsky, Nuclear targeting and intercellular communication in plants
Saikat Chowdhury , Assistant Professor, Cytoskeletal dynamics and regulation, cryo-electron microscopy and cell biology
Neta Dean, Glycosylation; fungal pathogenesis
Dale G. Deutsch, Marijuana; molecular neurobiology of anandamide
Ken Dill, Computer modeling of protein molecules and theory and principles of the machine mechanisms and evolution of cells
Jarrod B. French, Structure and function of protein complexes involved in cellular metabolism
J. Peter Gergen, Gene expression and development in Drosophila
Steven Glynn, Structure and mechanism of protein-unfolding machines in mitochondria
Bernadette C. Holdener, Genetic regulation of early mammalian development
Nancy Hollingsworth , Meiotic synapsis, recombination, and segregation in yeast
Wali Karzai , Quality control mechanisms in protein sysnthesis and homeostasis
Sasha Levy , Evolutionary dynamics, network dynamics, yeast genomics, high-throughput technology development
Erwin London , Membrane protein structure/translocation/folding
Ed Luk, Chromosome biology and genome regulation
Benjamin Martin , Stem cell maintenance and differentiation, Developmental mechanisms of cancer pathogenesis
David Q. Matus , Evolutionary, cell and developmental biological approaches to studying nematode uterine-vulval attachment and morphogenesis
Aaron Neiman , Vesicle trafficking and membrane/cytoskeletal interactions
Dada Pisconti , Muscle stem cells; muscle development, regeneration and aging; muscular dystrophy; extracellular matrix; biology of proteoglycans.
Sanford Simon , Extracellular degradation by neutrophil proteases
Steven Smith , Structure and function of membrane proteins
Gerald H. Thomsen , Growth factors /signal transduction in early vertebrate development
Department of Chemistry
Elizabeth Boon
Nitric oxide regulation of quorum sensing and biofilm formation in bacteria
Scott Laughlin
Chemical and biological strategies for deciphering neural circuitry
Carlos Simmerling
Development of tools for efficient and simulation of chemical systems and using them
to study the structure and dynamics of molecules involved in biological processes.
Peter Tonge
Spectroscopic insights into enzyme mechanisms and structure
Department of Medicine
Jian Cao, M.D.
Biology and prevention of cancer metastasis
Wen-Tien Chen
Proteases / integrins in cancer invasion, metastasis, angiogenesis
Berhane Ghebrehiwet
Biochemistry; function of the complement system
Yusuf Hannun
Bioactive lipids in cancer pathogenesis and therapeutics
The major goal of my research is to unravel the role of inflammation and obesity in promoting oncogenic KRAS-mediated pancreatic tumorigenesis
Cungui Mao
Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy
Lina M. Obeid
Bioactive lipids in Inflammation, Aging and Cancer
Ashley Snider
Bioactive lipids and dietary fatty acids in inflammation and cancer.
Vincent Yang
Biology and pathobiology of intestinal epithelial stem cells and colorectal cancer.
Huichun Zhan
Stem cell biology in normal and neoplastic hematopoiesis
Department of Molecular Genetics & Microbiology
Jorge Benach
Pathogenesis of spirochetal infections and their host responses
Nicolas Carpino
Positive and Negative Regulation of T cell Receptor Signaling
Bruce Futcher
Cell cycle, cyclins, and yeast genetics
Michael Hayman
Viral/cellular oncogenes; differentiation of erythroid cells
Patrick Hearing
Adenovirus regulation of cellular proliferation and gene expression; adenovirus vectors
for human gene therapy
Rickettsial pathogenesis and vaccine assembly for tick-borne rickettsioses
James Konopka
Signal transduction, morphogenesis and genetics of pathogenic fungi
Laurie Krug
My lab's research interests lie in understanding the molecular determinants of virus-host
interactions during chronic gammaherpesvirus infections using a mouse model pathogen.
Pawan Kumar
Immunology, gut microbiota-immune cells interaction. Intestinal and autoimmune inflammation
Erich R. Mackow
Viral Pathogenesis, Regulation of Innate Immunity, Hantavirus, Dengue Virus and Rotavirus
Regulation of Cell Signaling Responses, miRNAs and Endothelial cell functions.
Nancy Reich
Cytokine and Innate Immune Responses
Brian Sheridan
Mucosal Immunology, T cell memory, Vaccine design, Host-pathogen interactions
David Thanassi
Secretion of virulence factors by bacterial pathogens; pilus biogenesis by uropathogenic Escherichia
coli
Adrianus. W.M. van der Velden
Infectious Diseases Immunology; Host Interactions with Bacterial Pathogens; Bacterial
Immune Subversion
Eckard Wimmer
RNA virus genetics, replication, pathogenicity, cellular receptors
Department of Neurobiology and Behavior
Simon Halegoua
Molecular control of the neuronal phenotype
Maurice Kernan
Molecular basis of mechanical senses
Joel Levine
Cell-surface molecules of the developing nervous system
David McKinnon
Molecular physiology of sympathetic neurons and cardiac muscle
Howard Sirotkin
Genetic and molecular analysis of early vertebrate development
Lonnie Wollmuth
Molecular mechanisms of synaptic transmission
Department of Oral Biology and Pathology
Soosan Ghazizadeh
Epithelial stem cell biology; Skin bioengineering and gene therapy.
Department of Pathology
Jiang Chen
Skin and hair follicle development, maintenance and malignancy
Jun Chung
Anti-cancer drug discovery targeting tumor invasion and metastasis
Jingfang Ju
Post-transcriptional control of non-coding RNAs and RNA binding proteins in cancer
Richard R. Kew
Leukocyte chemotaxis/inflammation
Yupo Ma
Stem cell reprogramming and therapy, genome engineering, blood and marrow transplantation
Luis Martinez
Oncogenes and tumor suppressor genes, oncogenic functions of mutant p53
Ute Moll
Tumor suppressor genes; mechanism of p53 inactivation
Scott Powers
Genomic approaches to cancer research
Kenneth Shroyer
Cancer biomarkers as diagnostic adjuncts in cervical pathology and cytopathology;
cervical cancer and HPV
Eric Spitzer
Molecular biology of Cryptococcus neoformans
The evolution of molecular and cellular changes that occur during the development of colorectal and breast cancer.
Department of Pharmacological Sciences
Daniel Bogenhagen
Mitochondrial DNA; DNA repair
Leveraging microfluidics and optogenetics to elucidate molecular mechanisms of spindle orientation, ciliogenesis, polarity, actin cortex formation and axonogenesis
Chia-Hsin (Lori) Chan
Molecular mechanisms of cancer development; cancer metabolism and stemness
Holly Colognato
Extracellular matrix in the brain; roles during development and during neurodegeneration.
Bruce Demple
Defining new repair pathways for oxidative DNA damage in the nucleus and the mitochondria
of mammalian cells.
Michael A. Frohman
Lipid signaling pathways in immune responses, Alzheimer's disease, cardiovascular
disease, and cancer.
Miguel Garcia-Diaz
Genetic Toxicology/Mechanisms of mitochondrial gene expression
Arthur Grollman
Mechanisms of chemical mutagenesis/carcinogenesis
Hyungjin Kim
Mechanisms of DNA damage response and repair in cancer susceptibility pathways
Craig C. Malbon
Heterotrimetric G-proteins in development and cancer
Joav Prives
Cytoskeletal membrane interactions in muscle cells
Jessica C. Seeliger
Molecular mechanisms of bacterial cell membrane assembly
Markus Seeliger
Mechanism of Protein kinases and Ubiquitin Ligases in Cancer and Aging
Ken-Ichi Takemaru
Wnt Signaling in Development and Disease
Dongyan Tan
Structure and function of macromolecules involved in epigenetic regulation of gene
expression
Styliani-Anna Tsirka
Neuronal-microglial interactions in the central nervous system
The focus of the Okeoma lab is to elucidate the mechanism(s) by which host factors expressed in host cells or packaged into extracellular vesicles, such as exosomes regulate viral infections or facilitate disease manifestation, as in HIV and cancer.
Department of Physiology and Biophysics
Mark Bowen
Single molecule spectroscopy; Coordination of post-synaptic glutamate receptor signaling
by the MAGUK family of scaffolds
Richard Lin
Kinase signaling and cell proliferation
W. Todd Miller
Tyrosine phosphorylation and signal transduction
Ilan Spector
Neuronal differentiation and microfilaments
Thomas White
Molecular biology and physiology of gap junction channels
Brookhaven National Laboratory
F. William Studier
Phage T7 replication; large-scale nucleotide sequencing
Cold Spring Harbor Laboratory
Christopher Hammell
Understanding how temporal precision in gene regulation contributes to normal development
and how the modulation of protein translation impacts human cancer biology
James Hicks
Cancer genomics at the single cell level as a means to understand tumor inititation
and evolution and, further, to identify biomarkers for directing cancer therapy
Leemor Joshua-Tor
Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography
Adrian Krainer
mRNA splicing; gene expression; RNA-protein interaction
Robert Martienssen
Plant genetics; transposons; development; gene regulation; DNA methylation
Alea Mills
Cancer; development; aging; senescence; epigenetics
We study the genetics of cancer progression, gene dosage imbalances, and drug specificity
Spatial organization of gene expression
Arne Stenlund
DNA replication of papillomaviruses
Bruce Stillman
DNA replication and chromatin assembly in human and yeast cells
Nicholas K. Tonks
Characterization of protein tyrosine phosphatases
Lloyd Trotman
TheRapidCaP system to study metastatic prostate cancer genomes and their resistance
to therapy in vivo.
Christopher Vakoc
Chromatin; epigenetics; acute myeloid leukemia; self-renewal; RNAi screening; mouse
models of cancer
Linda Van Aelst
Signal transduction; Ras and Rac proteins, tumorigenesis
Michael H. Wigler
Growth control in yeast and mammalian cells