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Faculty

Department of Anesthesiology

Martin Kaczocha
Role of fatty acid binding proteins in pain, inflammation, and related pathophysiologies: Endocannabinoid pharmacology and development of novel therapeutics.

Department of Biochemistry and Cell Biology

Michael Airola,  Structural biology of lipid modifying enzymes

Nurit Ballas,   The cellular and molecular mechanisms underlying the autism spectrum disorder Rett Syndrome

Paul M. Bingham,  Genetic control of development and gene expression in animals

Deborah Brown  Cholesterol/sphingolipid-rich domains in membrane signaling

Vitaly Citovsky,  Nuclear targeting and intercellular communication in plants

Saikat Chowdhury Assistant Professor,   Cytoskeletal dynamics and regulation, cryo-electron microscopy and cell biology

Neta Dean,  Glycosylation; fungal pathogenesis

Ken Dill,  Computer modeling of protein molecules and theory and principles of the machine mechanisms and evolution of cells

Jarrod B. French,  Structure and function of protein complexes involved in cellular metabolism

J. Peter Gergen,  Gene expression and development in Drosophila

Steven Glynn,  Structure and mechanism of protein-unfolding machines in mitochondria

Bernadette C. Holdener,  Genetic regulation of early mammalian development

Nancy Hollingsworth , Meiotic synapsis, recombination, and segregation in yeast

Chi-Kuo Hu   Assistant Professor, biology of dormancy during development and aging, with the African killifish as the main research organism.

Wali Karzai , Quality control mechanisms in protein sysnthesis and homeostasis

Erwin London , Membrane protein structure/translocation/folding

Ed Luk,  Chromosome biology and genome regulation

Benjamin Martin , Stem cell maintenance and differentiation, Developmental mechanisms of cancer pathogenesis

David Q. Matus , Evolutionary, cell and developmental biological approaches to studying nematode uterine-vulval attachment and morphogenesis

Aaron Neiman , Vesicle trafficking and membrane/cytoskeletal interactions

Dada Pisconti , Muscle stem cells; muscle development, regeneration and aging; muscular dystrophy; extracellular matrix; biology of proteoglycans.

Sanford Simon , Extracellular degradation by neutrophil proteases

Steven Smith , Structure and function of membrane proteins

Gerald H. Thomsen , Growth factors /signal transduction in early vertebrate development

Department of Chemistry

Elizabeth Boon
Nitric oxide regulation of quorum sensing and biofilm formation in bacteria

Scott Laughlin
Chemical and biological strategies for deciphering neural circuitry

Carlos Simmerling
Development of tools for efficient and simulation of chemical systems and using them to study the structure and dynamics of molecules involved in biological processes.

Peter Tonge
Spectroscopic insights into enzyme mechanisms and structure
 

Department of Medicine

Agnieszka Bialkowska

Acute and chronic pancreatitis, pancreatic cancer development, animal models, pancreatic stromal and immune cell interactions, single-cell and bulk NGS

Wen-Tien Chen

Proteases / integrins in cancer invasion, metastasis, angiogenesis

Christopher Clarke

Oncogenic reprogramming of sphingolipid metabolism and role in tumorigenesis

Berhane Ghebrehiwet

Biochemistry; function of the complement system

Yusuf Hannun

Bioactive lipids in cancer pathogenesis and therapeutics

Weiqin Lu

The major goal of my research is to unravel the role of inflammation and obesity in promoting oncogenic KRAS-mediated pancreatic tumorigenesis

  Cungui Mao

Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy

Vincent Yang

Biology and pathobiology of intestinal epithelial stem cells and colorectal cancer.

Huichun Zhan

Stem cell biology in normal and neoplastic hematopoiesis
 

Department of Molecular Genetics & Microbiology

Jorge Benach
Pathogenesis of spirochetal infections and their host responses

Nicolas Carpino
Positive and Negative Regulation of T cell Receptor Signaling

Bruce Futcher
Cell cycle, cyclins, and yeast genetics

Patrick Hearing
Adenovirus regulation of cellular proliferation and gene expression; adenovirus vectors for human gene therapy

Hwan Kim

Rickettsial pathogenesis and vaccine assembly for tick-borne rickettsioses

James Konopka
Signal transduction, morphogenesis and genetics of pathogenic fungi

Pawan Kumar
Immunology, gut microbiota-immune cells interaction. Intestinal and autoimmune inflammation

Erich R. Mackow
Viral Pathogenesis, Regulation of Innate Immunity, Hantavirus, Dengue Virus and Rotavirus Regulation of Cell Signaling Responses, miRNAs and Endothelial cell functions.

Nancy Reich
Cytokine and Innate Immune Responses

Brian Sheridan
Mucosal Immunology, T cell memory, Vaccine design, Host-pathogen interactions

David Thanassi
Secretion of virulence factors by bacterial pathogens; pilus biogenesis by uropathogenic Escherichia coli

Adrianus. W.M. van der Velden
Infectious Diseases Immunology; Host Interactions with Bacterial Pathogens; Bacterial Immune Subversion

Department of Neurobiology and Behavior

Maurice Kernan
Molecular basis of mechanical senses

David McKinnon
Molecular physiology of sympathetic neurons and cardiac muscle

Markus Riessland

We use state-of-the-art molecular tools to study cell type-specific pathways that underlie selective vulnerability and cellular senescence in brain-aging, age-related neurodegeneration and Parkinson’s disease.

Howard Sirotkin

Genetic and molecular analysis of early vertebrate development

Lonnie Wollmuth
Molecular mechanisms of synaptic transmission

Department of Oral Biology and Pathology

Soosan Ghazizadeh
Epithelial stem cell biology; Skin bioengineering and gene therapy.

Department of Pathology

Jiang Chen
Skin and hair follicle development, maintenance and malignancy

Jun Chung
Anti-cancer drug discovery targeting tumor invasion and metastasis

Jingfang Ju
Post-transcriptional control of non-coding RNAs and RNA binding proteins in cancer

Richard R. Kew
Leukocyte chemotaxis/inflammation

Yupo Ma
Stem cell reprogramming and therapy, genome engineering, blood and marrow transplantation

Luis Martinez
Oncogenes and tumor suppressor genes, oncogenic functions of mutant p53

Ute Moll
Tumor suppressor genes; mechanism of p53 inactivation

Scott Powers
Genomic approaches to cancer research

Kenneth Shroyer
Cancer biomarkers as diagnostic adjuncts in cervical pathology and cytopathology; cervical cancer and HPV

Patricia Thompson-Carino

The evolution of molecular and cellular changes that occur during the development of colorectal and breast cancer.

Mehdi Damaghi

The role of tumor microenvironment in evolution of metabolic phenotypes in breast and ovarian cancer: from single cells to whole tumor analysis.

 

Department of Pharmacological Sciences

Christopher Brownlee

Leveraging microfluidics and optogenetics to elucidate molecular mechanisms of spindle orientation, ciliogenesis, polarity, actin cortex formation and axonogenesis

Holly Colognato
Extracellular matrix in the brain; roles during development and during neurodegeneration.

Bruce Demple
Defining new repair pathways for oxidative DNA damage in the nucleus and the mitochondria of mammalian cells.

Michael A. Frohman
Lipid signaling pathways in immune responses, Alzheimer's disease, cardiovascular disease, and cancer.

Miguel Garcia-Diaz
Genetic Toxicology/Mechanisms of mitochondrial gene expression

Arthur Grollman
Mechanisms of chemical mutagenesis/carcinogenesis

Hyungjin Kim
Mechanisms of DNA damage response and repair in cancer susceptibility pathways

Joav Prives
Cytoskeletal membrane interactions in muscle cells

Jessica C. Seeliger
Molecular mechanisms of bacterial cell membrane assembly

Markus Seeliger
Mechanism of Protein kinases and Ubiquitin Ligases in Cancer and Aging

Ken-Ichi Takemaru
Wnt Signaling in Development and Disease

Dongyan Tan
Structure and function of macromolecules involved in epigenetic regulation of gene expression

Styliani-Anna Tsirka
Neuronal-microglial interactions in the central nervous system

Chioma M. Okeoma

The focus of the Okeoma lab is to elucidate the mechanism(s) by which host factors expressed in host cells or packaged into extracellular vesicles, such as exosomes regulate viral infections or facilitate disease manifestation, as in HIV and cancer. 

Department of Physiology and Biophysics

Richard Lin
Kinase signaling and cell proliferation

W. Todd Miller
Tyrosine phosphorylation and signal transduction

Ilan Spector
Neuronal differentiation and microfilaments

Thomas White
Molecular biology and physiology of gap junction channels

Brookhaven National Laboratory

F. William Studier
Phage T7 replication; large-scale nucleotide sequencing
  

Cold Spring Harbor Laboratory

Christopher Hammell
Understanding how temporal precision in gene regulation contributes to normal development and how the modulation of protein translation impacts human cancer biology  


Leemor Joshua-Tor
Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography

Adrian Krainer
mRNA splicing; gene expression; RNA-protein interaction

Robert Martienssen
Plant genetics; transposons; development; gene regulation; DNA methylation

Alea Mills
Cancer; development; aging; senescence; epigenetics

David L. Spector

Spatial organization of gene expression

Bruce Stillman
DNA replication and chromatin assembly in human and yeast cells

Nicholas K. Tonks
Characterization of protein tyrosine phosphatases

Lloyd Trotman
TheRapidCaP system to study metastatic prostate cancer genomes and their resistance to therapy in vivo

David A. Tuveson

Our laboratory investigates the fundamental mechanisms that contribute to the pathogenesis of pancreatic cancer, and applies this information to the development of new therapeutic and diagnostic approaches

Christopher Vakoc
Chromatin; epigenetics; acute myeloid leukemia; self-renewal; RNAi screening; mouse models of cancer

Linda Van Aelst
Signal transduction; Ras and Rac proteins, tumorigenesis

Michael H. Wigler
Growth control in yeast and mammalian cells