Organic Chemistry

Organic chemistry research at Stony Brook covers synthetic and physical organic chemistry, organometallics, catalysis, bioorganic chemistry, medicinal chemistry, and materials chemistry. Our wide range of research projects includes development of new and efficient synthetic methods, including organometallic reagents, catalysts; syntheses of natural and unnatural compounds of special interest in medicinal chemistry or materials chemistry; elucidation of enzyme reaction mechanisms, protein-protein, structure-activity relationship of pharmaceutical agents such as anticancer agents, various enzyme inhibitors, and receptor antagonists; preparation of organic solids with designed supramolecular geometry; and the use of organic models to explore polymer structures and properties.

Underpinning it all is a strong commitment to organic synthesis, which is what gives organic chemistry its unique power as a creative science.


	Quinton Bruch Assistant Professor
	Dale Drueckhammer Professor. Computer-based design and synthesis of receptors and sensors for biomolecules. Design and synthesis of enzyme inhibitors. Enzyme reaction mechanisms
	Robert Grubbs Professor. My research group is interested in the common ground shared by polymer, organic, and materials chemistry and we are involved in the design, synthesis, and characterization of polymer-based organic materials.
	Frank Johnson Professor. Synthesis of viral enzyme inhibitors. Chemical aspects of genetic toxicology. New organo-alkali synthetic chemi
	Jeffrey Lipshultz Assistant Professor. Organic and organometallic photochemistry for development of catalytic reaction platforms aimed at valorization of feedstock chemicals and derivatization of bioactive molecules. Selective protein and peptide functionalization.
	Iwao Ojima Distinguished Professor. Design, synthesis, and structure-activity relationships of medicinally-active compounds, especially anticancer agents. Development of new synthetic methods based on asymmetric synthesis, homogeneous catalysis and organometalic chemistry.
	Nicole Sampson Distinguished Professor. Bioorganic chemistry and mechanistic enzymology. Investigation of the structure and function of cholesterol oxidase protein-membrane interactions, and its relationship to Mycobacterium tuberculosis pathogenesis. Synthesis of peptides and polymers to probe the role of ADAM proteins in mammalian fertilization.
	Peter Tonge Distinguished Professor. Biological chemistry and enzymology. Quantitating substrate strain in enzyme-catalyzed reactions using vibrational and NMR spectroscopies. Rational drug design. Pathogenesis of Mycobacterium tuberculosis. Structure-function studies of fluorescent proteins.

Faculty