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Organic Chemistry


Organic chemistry research at Stony Brook covers synthetic and physical organic chemistry, organometallics, catalysis, bioorganic chemistry, medicinal chemistry, and materials chemistry. Our wide range of research projects includes development of new and efficient synthetic methods, including organometallic reagents, catalysts; syntheses of natural and unnatural compounds of special interest in medicinal chemistry or materials chemistry; elucidation of enzyme reaction mechanisms, protein-protein, structure-activity relationship of pharmaceutical agents such as anticancer agents, various enzyme inhibitors, and receptor antagonists; preparation of organic solids with designed supramolecular geometry; and the use of organic models to explore polymer structures and properties.

Underpinning it all is a strong commitment to organic synthesis, which is what gives organic chemistry its unique power as a creative science.

 

   
Melanie Chiu

Melanie Chiu
Assistant Professor. Development of methods that use light to control polymer molecular weight distribution and copolymer sequence.

Dale Drueckhammer

Dale Drueckhammer
Professor. Computer-based design and synthesis of receptors and sensors for biomolecules. Design and synthesis of enzyme inhibitors. Enzyme reaction mechanisms

Robert Grubbs

Robert Grubbs
Professor. My research group is interested in the common ground shared by polymer, organic, and materials chemistry and we are involved in the design, synthesis, and characterization of polymer-based organic materials.

Frank Johnson

Frank Johnson
Professor. Synthesis of viral enzyme inhibitors. Chemical aspects of genetic toxicology. New organo-alkali synthetic chemi

Joseph Lauher

Joseph Lauher
Professor . Structural chemistry and X-ray crystallography, supramolecular chemistry and crystal engineering, hydrogen bonding, topochemical polymerizations, conjugated polymers. molecular graphics.

Lipshultz

Jeffrey Lipshultz
Assistant Professor. Organic and organometallic photochemistry for development of catalytic reaction platforms aimed at valorization of feedstock chemicals and derivatization of bioactive molecules. Selective protein and peptide functionalization.

Ming-Yu Ngai

Ming-Yu Ngai
Associate Professor. Synthetic methodology development using multifunctional catalysts and dual catalysis. Drug design and synthesis. Radio-tracer development for Positron Emission Tomography.

Iwao Ojima

Iwao Ojima
Distinguished Professor. Design, synthesis, and structure-activity relationships of medicinally-active compounds, especially anticancer agents. Development of new synthetic methods based on asymmetric synthesis, homogeneous catalysis and organometalic chemistry.

Nicole Sampson

Nicole Sampson
Distinguished Professor. Bioorganic chemistry and mechanistic enzymology. Investigation of the structure and function of cholesterol oxidase protein-membrane interactions, and its relationship to Mycobacterium tuberculosis pathogenesis. Synthesis of peptides and polymers to probe the role of ADAM proteins in mammalian fertilization.

Peter Tonge

Peter Tonge
Distinguished Professor. Biological chemistry and enzymology. Quantitating substrate strain in enzyme-catalyzed reactions using vibrational and NMR spectroscopies. Rational drug design. Pathogenesis of Mycobacterium tuberculosis. Structure-function studies of fluorescent proteins.