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Jeffrey Lipshultz, Assistant Professor

Scott Laughlin


A.B. Harvard College, 2013
Ph. D. Princeton University, 2018
Postdoctoral Associate, Massachusetts Institute of Technology, 2018-2022

713 Chemistry

The Lipshultz Group Website

research summary

We are a new organic and organometallic chemistry group interested in exploiting unique photochemical phenomena for the development of new synthetic transformations. In one research area, we will use in situ-generated organometallic complexes to catalytically access high energy heteroatom-centered radicals to engage C–H functionalizations, skeletal rearrangements, and fragment couplings for the generation of molecular complexity. A complementary project will entail the use of common organocatalytic modes to enable uncommon photochemistry, with an eye towards redefining the logic of organocatalytic functionalization. Building on this organocatalytic reaction development project, we will leverage similar photochemical phenomena to drive biomolecule derivatization. Across all project areas, we will make use of all available physical and analytical tools to study the underlying photochemical phenomena to drive deeper understanding and innovation in catalyst design, structure, and function.


Uniting Amide Synthesis and Activation by PIII/PV-Catalyzed Serial Condensation: Three-Component Assembly of 2-Amidopyridines.  J. M. Lipshultz, A. T. Radosevich. J. Am. Chem. Soc. 2021, 143, 14487–14494.

Main Group Redox Catalysis of Organopnictogens: Vertical Periodic Trends and Emerging Opportunities in Group 15.  J. M. Lipshultz,‡ G. Li,‡ A. T. Radosevich. J. Am. Chem. Soc. 2021, 143, 1699–1721. ‡Contributed equally

Organophosphorus-Catalyzed Relay Oxidation of H–Bpin: Electrophilic C–H Borylation of Heteroarenes. J. M. Lipshultz, Y. Fu, P. Liu, A. T. Radosevich. Chem. Sci. 2021, 12, 1031–1037.

Driving Recursive Dehydration by PIII/PV Catalysis: Annulation of Amines and Carboxylic Acids by Sequential C–N and C–C Bond Formation.  M. Lecomte,‡ J. M. Lipshultz,‡ S.-H. Kim-Lee, G. Li, A. T. Radosevich. J. Am. Chem. Soc. 2019, 141, 12507–12512. L ‡Contributed equally

Catalyst-Controlled Oligomerization for the Collective Synthesis of Polypyrroloindoline Natural Products. C. R. Jamison, J. J. Badillo, J. M. Lipshultz, R. J. Comito, D. W. C. MacMillan. Nat. Chem. 2017, 9, 1165–1169.

Merging Photoredox and Nickel Catalysis: The Direct Synthesis of Ketones via the Decarboxylative Arylation of α-Oxo Acids.L. Chu, J. M. Lipshultz, D. W. C. MacMillan. Angew. Chem. Int. Ed. 2015, 54, 7929–7933.