Better diagnoses, earlier interventions, more-efficient drug therapies, customized treatment plans. These are the promises of personalized medicine, also known as precision medicine or individualized medicine. Currently, numerous and significant advances have been achieved on the pathophysiological and genetic knowledge of numerous diseases. These advances are associated with the advent of new technologies related to diagnosis, treatment, and reduction of costs from genetic studies and implementation of new management approaches, resulting mainly from multicenter studies and meta-analyses. These studies provide a genomic blueprint to determine each person's unique disease susceptibility, define preventive measures and enable targeted therapies to promote wellness.