Department of Biochemistry and Cell Biology
144 Center for Molecular Medicine
Stony Brook University
Stony Brook, NY 11794-5215
Office Phone: 631-632- 2059
Lab Phone: 631-632-2060
We are interested in understanding the civil and mechanical engineering marvels within cells. Just like rebar and cables, which provide support to buildings and bridges, support structures of cells are made up of filamentous cytoskeletal elements like actin, microtubule and intermediate filaments. These dictate cellular morphology, generate forces for cell migration, and form intracellular tracks for movement of molecular motor proteins. These networks are highly regulated and are dynamic in nature. Different proteins interact with these filaments and regulate their polymerization, dissociation, or mediate connectivity between them. Dysregulation or anomaly of the cytoskeletal network are associated with wide range of diseases like developmental disorders, neurodegeneration, delayed wound healing, and cancer metastasis.
Our lab’s research focuses towards understanding how different cytoskeletal elements work in unison inside the cell, investigate the molecular basis of regulation of these networks, and how these participate in important cellular functions. We use cutting edge Cryo-electron microscopy (EM), novel image processing methodologies along with biochemical and biophysical techniques to decode these cellular engineering feats.