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Jarrod French - Assistant Professor

Sasha Levy Jarrod earned his Bachelor’s degree with a double major in Chemistry and Biology from Brock University in St. Catharines, Ontario, near his home town of Niagara Falls. He then joined the Tri-Institutional training program in Chemical Biology, offered jointly by Cornell University, Memorial Sloan-Kettering Cancer Center and Rockefeller University, for his PhD studies. In this unique program he was able to pursue his interests in science at the interface of Chemistry and Biology while developing expertise in mechanistic and structural enzymology. During this time, he developed a fascination with how large protein complexes and mesoscale assemblies are controlled and constructed within the cell. He pursued this curiosity throughout his postdoctoral work with Steven Benkovic at The Pennsylvania State University where he studied the regulation and assembly of the cellular body called the purinosome.

Jarrod joined the faculty at Stony Brook early in 2014 with a joint appointment in the Departments of Biochemistry & Cell Biology and Chemistry as part of a cluster hire in biomolecular imaging. He and the members of his lab use a highly collaborative, cross-disciplinary approach to determine the structure-function relationship of proteins and protein complexes, and to elucidate the fundamental mechanistic underpinnings of metabolic processes. The group has several projects ongoing including the structural and mechanistic characterization of multi-functional enzymes and enzyme complexes involved in nucleotide metabolism, structure/function studies of specific herpesvirus tegument proteins, the identification and characterization of proteins involved in nucleobase transport, mechanistic studies of photoactive flavoproteins, and the development of acoustofluidic tools to manipulate and pattern protein crystals. These projects involves the application of diverse tools and technologies including X-ray crystallography, super-resolution microscopy, chemical biology and mechanistic enzymology. The long term goal of this work is to understand how enzymes and other proteins control cellular metabolism in order to exploit this information to develop novel treatments for cancer, autoimmune diseases and metabolic disorders.

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