Graduate Bulletin

Spring 2018

FACULTY

Department of Anesthesiology

Martin Kaczocha

Role of fatty acid binding proteins in pain, inflammation, and related pathophysiologies: Endocannabinoid pharmacology and development of novel therapeutics.

 

Department of Biochemistry and Cell Biology

Paul M. Bingham

Genetic control of development and gene expression in animals

Deborah Brown

Cholesterol/sphingolipid-rich domains in membrane signaling

Vitaly Citovsky

Nuclear targeting and intercellular communication in plants

   

Neta Dean

Glycosylation; fungal pathogenesis

Dale G. Deutsch

Marijuana; molecular neurobiology of anandamide

Jarrod B. French

Structure and function of protein complexes involved in cellular metabolism

J. Peter Gergen

Gene expression and development in Drosophila

Steven Glynn

Structure and mechanism of protein-unfolding machines in mitochondria

Robert Haltiwanger

Glycobiology; biosynthesis, structure, and function

Bernadette C. Holdener

Genetic regulation of early mammalian development

Nancy Hollingsworth

Meiotic synapsis, recombination, and segregation in yeast

Wali Karzai

Structure and function of RNA-binding proteins and biochemical studies of the SmpB•tmRNA quality control system

Sasha Levy

Evolutionary dynamics, network dynamics, yeast genomics, high-throughput technology development

Huilin Li

Structure and function of large protein machines

Erwin London

Membrane protein structure/translocation/folding

Ed Luk

Chromosome biology and genome regulation

Benjamin Martin

Stem cell maintenance and differentiation, Developmental mechanisms of cancer pathogenesis

David Q. Matus

Evolutionary, cell and developmental biological approaches to studying nematode uterine-vulval attachment and morphogenesis

Aaron Neiman

Vesicle trafficking and membrane/cytoskeletal interactions

Sanford Simon

Extracellular degradation by neutrophil proteases

Steven Smith

Structure and function of membrane proteins

Rolf Sternglanz

Chromatin structure and function; gene expression; HATs

Gerald H. Thomsen

Growth factors /signal transduction in early vertebrate development

 

Department of Chemistry

Elizabeth Boon

Nitric oxide regulation of quorum sensing and biofilm formation in bacteria

Isaac Carrico

 

 

 

 

Liang Gao

The research in our group centers around the concept of chemical biology. In paticular, we introduce unnatural monomers into the biopolymers of life (proteins, oligosaccharides, oligonucleotides) for the purpose of tracking or perturbing biological processes.

 

 

Super-resolution fluorescence microscopy, 3D live fluorescence imaging and quantitative analysis of 3D image data sets

Carlos Simmerling

Development of tools for efficient and simulation of chemical systems and using them to study the structure and dynamics of molecules involved in biological processes.

Peter Tonge

Spectroscopic insights into enzyme mechanisms and structure

 

 

Department of Medicine

   
   

Berhane Ghebrehiwet

Biochemistry; function of the complement system

Yusuf Hannun

Bioactive lipids in cancer pathogenesis and therapeutics

Richard Lin

Kinase signaling and cell proliferation

Cungui Mao

Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy

Lina M. Obeid

Bioactive lipids in Inflammation, Aging and Cancer

William Van Nostrand

Vascular functions of Alzheimer's disease amyloid beta-protein

Vincent Yang

Biology and pathobiology of intestinal epithelial stem cells and colorectal cancer.

 

Department of Molecular Genetics & Microbiology

Jorge Benach

Pathogenesis of spirochetal infections and their host responses

Nicolas Carpino

Positive and Negative Regulation of T cell Receptor Signaling

Bruce Futcher

Cell cycle, cyclins, and yeast genetics

Michael Hayman

Viral/cellular oncogenes; differentiation of erythroid cells

Patrick Hearing

Adenovirus regulation of cellular proliferation and gene expression; adenovirus vectors for human gene therapy

James Konopka

Signal transduction, morphogenesis and genetics of pathogenic fungi

Laurie Krug

My lab's research interests lie in understanding the molecular determinants of virus-host interactions during chronic gammaherpesvirus infections using a mouse model pathogen.

Janet Leatherwood

Cell cycle control and DNA replication in fission yeast

Erich R. Mackow

Viral Pathogenesis, Regulation of Innate Immunity, Hantavirus, Dengue Virus and Rotavirus Regulation of Cell Signaling Responses, miRNAs and Endothelial cell functions.

Nancy Reich

Cytokine and Innate Immune Responses

Brian Sheridan

Mucosal Immunology, T cell memory, Vaccine design, Host-pathogen interactions

David Thanassi

Secretion of virulence factors by bacterial pathogens; pilus biogenesis by uropathogenic Escherichia coli

Adrianus. W.M. van der Velden

Infectious Diseases Immunology; Host Interactions with Bacterial Pathogens; Bacterial Immune Subversion

Eckard Wimmer

RNA virus genetics, replication, pathogenicity, cellular receptors

 

 

 

Department of Neurobiology and Behavior

Simon Halegoua

Molecular control of the neuronal phenotype

Maurice Kernan

Molecular basis of mechanical senses

Joel Levine

Cell-surface molecules of the developing nervous system

David McKinnon

Molecular physiology of sympathetic neurons and cardiac muscle

Howard Sirotkin

Genetic and molecular analysis of early vertebrate development

Lonnie Wollmuth

Molecular mechanisms of synaptic transmission

 

Department of Oral Biology and Pathology

Soosan Ghazizadeh

Epithelial stem cell biology; Skin bioengineering and gene therapy.

 

Department of Pathology

Jiang Chen

Skin and hair follicle development, maintenance and malignancy

Howard B. Fleit

Leukocyte Fc receptors; macrophage differentiation

Martha Furie

Host inflammatory response to bacterial infections.

Jingfang Ju

Post-transcriptional control of non-coding RNAs and RNA binding proteins in cancer

Richard R. Kew

Leukocyte chemotaxis/inflammation

Yupo Ma

Stem cell reprogramming and therapy, genome engineering, blood and marrow transplantation

Ute Moll

Tumor suppressor genes; mechanism of p53 inactivation

Kenneth Shroyer

Cancer biomarkers as diagnostic adjuncts in cervical pathology and cytopathology; cervical cancer and HPV

Eric Spitzer

Molecular biology of Cryptococcus neoformans

 

Department of Pharmacological Sciences

Adan Aguirre

Stem cell biology in the central nervous system and neurobiology in health and disease

Daniel Bogenhagen

Mitochondrial DNA; DNA repair

Holly Colognato

Extracellular matrix in the brain; roles during development and during neurodegeneration.

Michael A. Frohman

Lipid signaling pathways in immune responses, Alzheimer's disease, cardiovascular disease, and cancer.

Miguel Garcia-Diaz

Genetic Toxicology/Mechanisms of mitochondrial gene expression

   

Craig C. Malbon

Heterotrimetric G-proteins in development and cancer

Joav Prives

Cytoskeletal membrane interactions in muscle cells

Jessica C. Seeliger

We are applying biochemical, microbiological and biophysical methods to fundamental questions in bacterial membrane biogenesis as they relate to Mycobacterium tuberculosis, the bacterium that causes tuberculosis, and to bacterial pathogenesis in general: How is lipid biosynthesis accomplished at the cytosol-membrane interface? What are the molecular mechanisms underlying bacterial membrane assembly? How can we subvert lipid biosynthesis and membrane assembly pathways for antimicrobial therapy?

Markus Seeliger

Mechanism of Protein kinases and Ubiquitin Ligases in Cancer and Aging

Orlando Schärer

Chemical Biology of DNA damage and repair.

Ken-Ichi Takemaru

Wnt Signaling in Development and Disease

Styliani-Anna Tsirka

Neuronal-microglial interactions in the central nervous system

   

 

Department of Physiology and Biophysics

Mark Bowen

Single molecule spectroscopy; Coordination of post-synaptic glutamate receptor signaling by the MAGUK family of scaffolds

W. Todd Miller

Tyrosine phosphorylation and signal transduction

Suzanne Scarlata

Cell signaling through heterotrimeric G proteins

Ilan Spector

Neuronal differentiation and microfilaments

Hsien-yu Wang

Our research group focuses on Wnt signaling in 1) regulation of cell signaling and 2) differentiation of embryonic stem cells.

Thomas White

Molecular biology and physiology of gap junction channels