Graduate Bulletin
Spring 2018
FACULTY
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Department of Anesthesiology |
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Role of fatty acid binding proteins in pain, inflammation, and related pathophysiologies: Endocannabinoid pharmacology and development of novel therapeutics. |
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Department of Biochemistry and Cell Biology |
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Genetic control of development and gene expression in animals |
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Cholesterol/sphingolipid-rich domains in membrane signaling |
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Nuclear targeting and intercellular communication in plants |
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Glycosylation; fungal pathogenesis |
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Marijuana; molecular neurobiology of anandamide |
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Structure and function of protein complexes involved in cellular metabolism |
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Gene expression and development in Drosophila |
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Structure and mechanism of protein-unfolding machines in mitochondria |
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Glycobiology; biosynthesis, structure, and function |
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Genetic regulation of early mammalian development |
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Meiotic synapsis, recombination, and segregation in yeast |
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Structure and function of RNA-binding proteins and biochemical studies of the SmpB•tmRNA quality control system |
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Evolutionary dynamics, network dynamics, yeast genomics, high-throughput technology development |
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Structure and function of large protein machines |
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Membrane protein structure/translocation/folding |
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Chromosome biology and genome regulation |
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Stem cell maintenance and differentiation, Developmental mechanisms of cancer pathogenesis |
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Evolutionary, cell and developmental biological approaches to studying nematode uterine-vulval attachment and morphogenesis |
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Vesicle trafficking and membrane/cytoskeletal interactions |
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Extracellular degradation by neutrophil proteases |
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Structure and function of membrane proteins |
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Chromatin structure and function; gene expression; HATs |
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Growth factors /signal transduction in early vertebrate development |
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Department of Chemistry |
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Nitric oxide regulation of quorum sensing and biofilm formation in bacteria |
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Isaac Carrico
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The research in our group centers around the concept of chemical biology. In paticular, we introduce unnatural monomers into the biopolymers of life (proteins, oligosaccharides, oligonucleotides) for the purpose of tracking or perturbing biological processes.
Super-resolution fluorescence microscopy, 3D live fluorescence imaging and quantitative analysis of 3D image data sets |
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Development of tools for efficient and simulation of chemical systems and using them to study the structure and dynamics of molecules involved in biological processes. |
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Spectroscopic insights into enzyme mechanisms and structure |
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Department of Medicine |
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Biochemistry; function of the complement system |
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Bioactive lipids in cancer pathogenesis and therapeutics |
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Kinase signaling and cell proliferation |
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Cungui Mao |
Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy |
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Bioactive lipids in Inflammation, Aging and Cancer |
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Vascular functions of Alzheimer's disease amyloid beta-protein |
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Biology and pathobiology of intestinal epithelial stem cells and colorectal cancer. |
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Department of Molecular Genetics & Microbiology |
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Pathogenesis of spirochetal infections and their host responses |
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Positive and Negative Regulation of T cell Receptor Signaling |
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Cell cycle, cyclins, and yeast genetics |
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Viral/cellular oncogenes; differentiation of erythroid cells |
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Adenovirus regulation of cellular proliferation and gene expression; adenovirus vectors for human gene therapy |
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Signal transduction, morphogenesis and genetics of pathogenic fungi |
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My lab's research interests lie in understanding the molecular determinants of virus-host interactions during chronic gammaherpesvirus infections using a mouse model pathogen. |
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Cell cycle control and DNA replication in fission yeast |
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Viral Pathogenesis, Regulation of Innate Immunity, Hantavirus, Dengue Virus and Rotavirus Regulation of Cell Signaling Responses, miRNAs and Endothelial cell functions. |
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Cytokine and Innate Immune Responses |
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Mucosal Immunology, T cell memory, Vaccine design, Host-pathogen interactions |
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Secretion of virulence factors by bacterial pathogens; pilus biogenesis by uropathogenic Escherichia coli |
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Infectious Diseases Immunology; Host Interactions with Bacterial Pathogens; Bacterial Immune Subversion |
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RNA virus genetics, replication, pathogenicity, cellular receptors |
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Department of Neurobiology and Behavior |
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Molecular control of the neuronal phenotype |
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Molecular basis of mechanical senses |
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Cell-surface molecules of the developing nervous system |
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Molecular physiology of sympathetic neurons and cardiac muscle |
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Genetic and molecular analysis of early vertebrate development |
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Molecular mechanisms of synaptic transmission |
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Department of Oral Biology and Pathology |
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Epithelial stem cell biology; Skin bioengineering and gene therapy. |
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Department of Pathology |
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Skin and hair follicle development, maintenance and malignancy |
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Leukocyte Fc receptors; macrophage differentiation |
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Host inflammatory response to bacterial infections. |
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Post-transcriptional control of non-coding RNAs and RNA binding proteins in cancer |
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Leukocyte chemotaxis/inflammation |
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Stem cell reprogramming and therapy, genome engineering, blood and marrow transplantation |
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Tumor suppressor genes; mechanism of p53 inactivation |
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Cancer biomarkers as diagnostic adjuncts in cervical pathology and cytopathology; cervical cancer and HPV |
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Molecular biology of Cryptococcus neoformans |
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Department of Pharmacological Sciences |
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Stem cell biology in the central nervous system and neurobiology in health and disease |
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Mitochondrial DNA; DNA repair |
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Extracellular matrix in the brain; roles during development and during neurodegeneration. |
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Lipid signaling pathways in immune responses, Alzheimer's disease, cardiovascular disease, and cancer. |
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Genetic Toxicology/Mechanisms of mitochondrial gene expression |
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Heterotrimetric G-proteins in development and cancer |
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Cytoskeletal membrane interactions in muscle cells |
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We are applying biochemical, microbiological and biophysical methods to fundamental questions in bacterial membrane biogenesis as they relate to Mycobacterium tuberculosis, the bacterium that causes tuberculosis, and to bacterial pathogenesis in general: How is lipid biosynthesis accomplished at the cytosol-membrane interface? What are the molecular mechanisms underlying bacterial membrane assembly? How can we subvert lipid biosynthesis and membrane assembly pathways for antimicrobial therapy? |
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Mechanism of Protein kinases and Ubiquitin Ligases in Cancer and Aging |
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Chemical Biology of DNA damage and repair. |
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Wnt Signaling in Development and Disease |
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Neuronal-microglial interactions in the central nervous system |
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Department of Physiology and Biophysics |
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Single molecule spectroscopy; Coordination of post-synaptic glutamate receptor signaling by the MAGUK family of scaffolds |
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Tyrosine phosphorylation and signal transduction |
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Cell signaling through heterotrimeric G proteins |
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Neuronal differentiation and microfilaments |
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Our research group focuses on Wnt signaling in 1) regulation of cell signaling and 2) differentiation of embryonic stem cells. |
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Molecular biology and physiology of gap junction channels |
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