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Faculty

Department of Anesthesiology
Martin Kaczocha Role of fatty acid binding proteins in pain, inflammation, and related pathophysiologies: Endocannabinoid pharmacology and development of novel therapeutics.
 

Department of Biochemistry and Cell Biology

Paul M. Bingham Genetic control of development and gene expression in animals
Deborah Brown Cholesterol/sphingolipid-rich domains in membrane signaling
Vitaly Citovsky Nuclear targeting and intercellular communication in plants
Kevin Czaplinski Post-transcriptional control of gene expression in the nervous system
Neta Dean Glycosylation; fungal pathogenesis
Dale G. Deutsch Marijuana; molecular neurobiology of anandamide
Jarrod B. French Structure and function of protein complexes involved in cellular metabolism
J. Peter Gergen Gene expression and development in Drosophila

Steven Glynn

Structure and mechanism of protein-unfolding machines in mitochondria
Robert Haltiwanger Glycobiology; biosynthesis, structure, and function
Bernadette C. Holdener Genetic regulation of early mammalian development
Nancy Hollingsworth Meiotic synapsis, recombination, and segregation in yeast
Wali Karzai Structure and function of RNA-binding proteins and biochemical studies of the SmpB•tmRNA quality control system
Sasha Levy Evolutionary dynamics, network dynamics, yeast genomics, high-throughput technology development
Huilin Li Structure and function of large protein machines
Erwin London Membrane protein structure/translocation/folding
Ed Luk Chromosome biology and genome regulation
Harvard Lyman Photocontrol of chloroplast development
Kenneth B. Marcu Antibody class switch mechanism; NFkB kinases; Myc gene control
Benjamin Martin Stem cell maintenance and differentiation, Developmental mechanisms of cancer pathogenesis
David Q. Matus Evolutionary, cell and developmental biological approaches to studying nematode uterine-vulval attachment and morphogenesis
Aaron Neiman Vesicle trafficking and membrane/cytoskeletal interactions
Nisson Schechter Homeobox and filament proteins in neuronal differentiation
Sanford Simon Extracellular degradation by neutrophil proteases
Steven Smith Structure and function of membrane proteins
Rolf Sternglanz Chromatin structure and function; gene expression; HATs
Gerald H. Thomsen Growth factors /signal transduction in early vertebrate development
 

Department of Chemistry

Elizabeth Boon Nitric oxide regulation of quorum sensing and biofilm formation in bacteria
Liang Gao Super-resolution fluorescence microscopy, 3D live fluorescence imaging and quantitative analysis of 3D image data sets
Carlos Simmerling Development of tools for efficient and simulation of chemical systems and using them to study the structure and dynamics of molecules involved in biological processes.
Peter Tonge Spectroscopic insights into enzyme mechanisms and structure
   

Department of Medicine

Jian Cao, M.D. Biology and prevention of cancer metastasis
Wen-Tien Chen Proteases / integrins in cancer invasion, metastasis, angiogenesis
Berhane Ghebrehiwet Biochemistry; function of the complement system
Yusuf Hannun Bioactive lipids in cancer pathogenesis and therapeutics
Richard Lin Kinase signaling and cell proliferation
Cungui Mao Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy
Lina M. Obeid Bioactive lipids in Inflammation, Aging and Cancer
Mario Rebecchi Phospholipases and signal transduction
Roy Steigbigel Immune dysfunction induced by HIV infection
William Van Nostrand Vascular functions of Alzheimer's disease amyloid beta-protein
Vincent Yang Biology and pathobiology of intestinal epithelial stem cells and colorectal cancer.
 

Department of Molecular Genetics & Microbiology

Jorge Benach
Pathogenesis of spirochetal infections and their host responses
Nicolas Carpino Positive and Negative Regulation of T cell Receptor Signaling
Bruce Futcher Cell cycle, cyclins, and yeast genetics
Michael Hayman Viral/cellular oncogenes; differentiation of erythroid cells
Patrick Hearing Adenovirus regulation of cellular proliferation and gene expression; adenovirus vectors for human gene therapy
James Konopka Signal transduction, morphogenesis and genetics of pathogenic fungi
Laurie Krug My lab's research interests lie in understanding the molecular determinants of virus-host interactions during chronic gammaherpesvirus infections using a mouse model pathogen.
Janet Leatherwood Cell cycle control and DNA replication in fission yeast
Erich R. Mackow Viral Pathogenesis, Regulation of Innate Immunity, Hantavirus, Dengue Virus and Rotavirus Regulation of Cell Signaling Responses, miRNAs and Endothelial cell functions.
Nancy Reich

Cytokine and Innate Immune Responses

David Thanassi Secretion of virulence factors by bacterial pathogens; pilus biogenesis by uropathogenic Escherichia coli
Adrianus. W.M. van der Velden Infectious Diseases Immunology; Host Interactions with Bacterial Pathogens; Bacterial Immune Subversion
Eckard Wimmer RNA virus genetics, replication, pathogenicity, cellular receptors
Wei-Xing Zong Molecular regulation of apoptotic and necrotic cell death.
 

Department of Neurobiology and Behavior

Simon Halegoua Molecular control of the neuronal phenotype
Maurice Kernan Molecular basis of mechanical senses
Joel Levine Cell-surface molecules of the developing nervous system
David McKinnon Molecular physiology of sympathetic neurons and cardiac muscle
Howard Sirotkin Genetic and molecular analysis of early vertebrate development
Lonnie Wollmuth Molecular mechanisms of synaptic transmission
 

Department of Oral Biology and Pathology

Soosan Ghazizadeh Epithelial stem cell biology; Skin bioengineering and gene therapy.
 

Department of Pathology

Jiang Chen Skin and hair follicle development, maintenance and malignancy
Howard B. Fleit Leukocyte Fc receptors; macrophage differentiation
Martha Furie Host inflammatory response to bacterial infections.
Jingfang Ju Post-transcriptional control of non-coding RNAs and RNA binding proteins in cancer
Richard R. Kew Leukocyte chemotaxis/inflammation
Yupo Ma Stem cell reprogramming and therapy, genome engineering, blood and marrow transplantation
Ute Moll Tumor suppressor genes; mechanism of p53 inactivation
Kenneth Shroyer Cancer biomarkers as diagnostic adjuncts in cervical pathology and cytopathology; cervical cancer and HPV
Eric Spitzer Molecular biology of Cryptococcus neoformans
 

Department of Pharmacological Sciences

Daniel Bogenhagen Mitochondrial DNA; DNA repair
Holly Colognato Extracellular matrix in the brain; roles during development and during neurodegeneration.
Michael A. Frohman Lipid signaling pathways in immune responses, Alzheimer's disease, cardiovascular disease, and cancer.
Miguel Garcia-Diaz Genetic Toxicology/Mechanisms of mitochondrial gene expression
Arthur Grollman Mechanisms of chemical mutagenesis/carcinogenesis
Craig C. Malbon Heterotrimetric G-proteins in development and cancer
Masaaki Moriya Cellular responses to DNA damage.
Joav Prives Cytoskeletal membrane interactions in muscle cells
Jessica C. Seeliger We are applying biochemical, microbiological and biophysical methods to fundamental questions in bacterial membrane biogenesis as they relate to Mycobacterium tuberculosis, the bacterium that causes tuberculosis, and to bacterial pathogenesis in general: How is lipid biosynthesis accomplished at the cytosol-membrane interface? What are the molecular mechanisms underlying bacterial membrane assembly? How can we subvert lipid biosynthesis and membrane assembly pathways for antimicrobial therapy?
Markus Seeliger Mechanism of Protein kinases and Ubiquitin Ligases in Cancer and Aging
Orlando Schärer Chemical Biology of DNA damage and repair.
Ken-Ichi Takemaru Wnt Signaling in Development and Disease
Styliani-Anna Tsirka Neuronal-microglial interactions in the central nervous system
 

Department of Physiology and Biophysics

Mark Bowen Single molecule spectroscopy; Coordination of post-synaptic glutamate receptor signaling by the MAGUK family of scaffolds
W. Todd Miller Tyrosine phosphorylation and signal transduction
Suzanne Scarlata Cell signaling through heterotrimeric G proteins
Ilan Spector Neuronal differentiation and microfilaments
Hsien-yu Wang Our research group focuses on Wnt signaling in 1) regulation of cell signaling and 2) differentiation of embryonic stem cells.
Thomas White Molecular biology and physiology of gap junction channels
 

Brookhaven National Laboratory

F. William Studier Phage T7 replication; large-scale nucleotide sequencing
 

Cold Spring Harbor Laboratory

Gregory Hannon Growth control in mammalian cells; post-transcriptional gene silencing
James Hicks Cancer genomics at the single cell level as a means to understand tumor inititation and evolution and, further, to identify biomarkers for directing cancer therapy
Leemor Joshua-Tor Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography
Adrian Krainer mRNA splicing; gene expression; RNA-protein interaction
Robert Martienssen Plant genetics; transposons; development; gene regulation; DNA methylation
Alea Mills Cancer; development; aging; senescence; epigenetics
David L. Spector Spatial organization of gene expression
Arne Stenlund DNA replication of papillomaviruses
Bruce Stillman DNA replication and chromatin assembly in human and yeast cells
Nicholas K. Tonks Characterization of protein tyrosine phosphatases
Christopher Vakoc Chromatin; epigenetics; acute myeloid leukemia; self-renewal; RNAi screening; mouse models of cancer
Linda Van Aelst Signal transduction; Ras and Rac proteins, tumorigenesis
Michael H. Wigler Growth control in yeast and mammalian cells
   

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