Study Suggests Targeting Invasive Cells Not Dividing Cells to Halt Cancer

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Stony Brook biochemistry researchers detail findings in journal Developmental Cell

David Q. Matus, PhD, (seated far right), in his Stony Brook laboratory where researchers study cells and cancer processes. Also involved in the research are, from left: Mana Chandhok, a PhD student; Ivan Chavez, a Master’s student, and Wan Zhang, laboratory technician. On the computer screen is a microscopic image of a C. elegans anchor cell (purple area) invading through the tissue membrane (green area).

David Q. Matus, PhD, (seated far right), in his Stony Brook laboratory where researchers study cells and cancer processes. Also involved in the research are, from left: Mana Chandhok, a PhD student; Ivan Chavez, a Master’s student, and Wan Zhang, laboratory technician. On the computer screen is a microscopic image of a C. elegans anchor cell (purple area) invading through the tissue membrane (green area).

October 26, 2015 — Most cancer drugs are designed to target dividing cells, but a new study by Stony Brook University researchers suggests that targeting invasive cells may be a new strategy to treat metastatic cancer. The approach is based on the finding that cells in C. elegans, a roundworm nematode, cannot divide and invade at the same time. The research, published in the journal Developmental Cell, is the first study to definitively show the dichotomy between cell division and cell invasion.

Uncontrolled cell division is a hallmark of cancer. In the paper titled “Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression,” lead author David Q. Matus, PhD, an Assistant Professor in the Department of Biochemistry & Cell Biology at Stony Brook University, and colleagues found that only when roundworm cells stop dividing can they become invasive. When cells become invasive, it is the most lethal to a host, as they are the cells that escape tumor tissue to travel and form new tumors.

“Our finding changes how we think about cancer to some level,” said Dr. Matus. “While it will remain important to target dividing cells – as cancer is a disease of uncontrolled cell division – we need to figure out how to target non-dividing cells too since they are the invasive ones.

The team used cells from the worm’s developing uterus called anchor cells to illustrate the division/invasion process. The anchor cells have to invade through a cellular tissue membrane to contact the cells that become the worm’s egg-laying apparatus. Cancer cells operate in a similar manner when leaving one tissue to form another.

Dr. Matus explained that continued research with anchor cells and ongoing genetic analyses of them may further reveal just why they cannot divide and invade at the same time. The research could form the basis of an approach to testing cancer cells and the invasive process.

Co-authors of the paper include: Abraham Kohrman and Wan Zhang of the Department of Biochemistry & Cell Biology at Stony Brook Univesity; Lauren L. Lohmer, Laura C. Kelley, Adam J. Schindler, Qiuyi Chi, and David R. Sherwood of the Department of Biology at Duke University; and Michalis Barkoulas of the Imperial College of London.

The research is supported in part by the National Institutes of Health, the American Cancer Society, the National Cancer Institute, and the Leukemia and Lymphoma Society.

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