taxthumbNew Generation Taxoids and Taxanes

Paclitaxel and docetaxel have developed into two of the most widely used agents for cancer chemotherapy, with combined sales of roughly 2.8 billion dollars in 2006, however, their lack of tumor-specificity frequently causes the patient to suffer from serious and dangerous side effects. Click to read more

 

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Tumor-targeting Drug Delivery

The drug discovery program includes tumor-specific drug delivery systems, “guided molecular missiles” in the fight against cancer. Despite the significant progress in the development of cancer detection, prevention, surgery and therapy, there is still no common cure for this disease. Click to read more


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Anti-microbials Targeting FtsZ

The program also includes novel antibacterial agents against drug-resistant tuberculosis, MRSA, VRE and other pathogens. Despite extensive research in the last 40 years, the drugs used to treat these infections are still limited  to  rather  classical  antibacterial  drugs  that  target  cell   wall biosynthesis, nucleic acid synthesis, protein synthesis, etc.   Click to read more

 

cyclothumb2New Synthetic Methods and Asymmetric Synthesis

The Ojima Laboratory has been exploring and developing new methodologies, especially based on catalytic organic transformations, including enantioselective processes, cyclohydrocarbonylations and higher order cycloadditions and carbocyclizations, which provide the basis for the efficient syntheses of biologically active substances of medicinal interest, such as those anticancer and antibacterial agents mentioned above. Click to read more

 

 

New and efficient synthetic methodology development
Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400 Phone: (631) 632-7890