taxthumbNew Generation Taxoids and Taxanes

Paclitaxel and docetaxel have developed into two of the most widely used agents for cancer chemotherapy, with combined sales of roughly 2.8 billion dollars in 2006, however, their lack of tumor-specificity frequently causes the patient to suffer from serious and dangerous side effects. Click to read more



Tumor-targeting Drug Delivery

The drug discovery program includes tumor-specific drug delivery systems, “guided molecular missiles” in the fight against cancer. Despite the significant progress in the development of cancer detection, prevention, surgery and therapy, there is still no common cure for this disease. Click to read more





Anti-microbials Targeting FtsZ

The program also includes novel antibacterial agents against drug-resistant tuberculosis, MRSA, VRE and other pathogens. Despite extensive research in the last 40 years, the drugs used to treat these infections are still limited  to  rather  classical  antibacterial  drugs  that  target  cell   wall biosynthesis, nucleic acid synthesis, protein synthesis, etc.   Click to read more



cyclothumb2New Synthetic Methods and Asymmetric Synthesis

The Ojima Laboratory has been exploring and developing new methodologies, especially based on catalytic organic transformations, including enantioselective processes, cyclohydrocarbonylations and higher order cycloadditions and carbocyclizations, which provide the basis for the efficient syntheses of biologically active substances of medicinal interest, such as those anticancer and antibacterial agents mentioned above. Click to read more



FABP MechanismFatty Acid Binding Protein (FABP) Inhibitors

Fatty acids play many important roles in the body.  One such fatty acid is anandamide, an endocannabinoid that is linked to the regulation of stress, pain, and inflammation.  Fatty acids, because of their hydrophobicity, require the help of fatty acid binding proteins (FABPs) to be transported throughout cells.  Anandamide targets cannabinoid receptors (CB receptors) on cell surface.  Activation of the CB, receptor leads to pain relief and stress relief. Click to read more




BoNTBotulinum Neurotoxin A (BoNT/A) Inhibitors

Botulinum neurotoxins (BoNTs), produced by anaerobic bacteria Clostridium botulinum are the most potent neurotoxins. BoNTs are classified by the Centers for Disease Control and prevention (CDC) as category A bioterrorism agents. They exist as seven distinct serotypes (A-G) out of which, Botulinum neurotoxin A (BoNT/A) is the most potent with an LD50 of 1.3 ng/kg. Click to read more
New and efficient synthetic methodology development
Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400 Phone: (631) 632-7890
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