Recent Publications

“Enatioselective synthesis of 1-vinyltetrahydroisoquinolines via Pd-catalyzed intramolecular asymmetric allylic
amination reactions”, C.-W. Chien, C. Shi, C.-F. Lin, and I. Ojima, Tetrahedron (2011) submitted. [Special Issue for
Tetrahedron Prize: Sotoshi Omura]

"Formal Total Synthesis of Enantiopure Schulzeines A-C via Pd-Catalyzed Intramolecular Asymmetric Allylic
Amination", C.-F. Lin and I. Ojima, J. Org. Chem. (2011) submitted.

“Targeted and armed oncolytic adenoviruses via chemoselective modification”, P. S. Banerjee, E. S. Zuniga, I. Ojima and
I. S. Carrico, Bioorg. Med. Chem. Lett. (2011) submitted. [Special Issue for Carolyn Bertozzi]

“Novel taxanes effectively suppress subcutaneous rat lymphoma: role of disposition, transport, metabolism, in vitro
potency and expression of angiogenesis genes”, B. Otová, I. Ojima, R. Václavíková, J. Hrdý, M. Ehrlichová, P. Souček,
J. Vobořilová, V. Němcová, I. Zanardi, S. Horský, J. Kovář, and I. Gut, Invest. New Drugs (2011) Epub online
(3/30/2011)

“Synthesis of Chiral Biphenol-Based Diphosphonite Ligands and Their Application to Pd-Catalyzed Intermolecular
Asymmetric Allylic Amination”, C. Shi, C.-W. Chien and I. Ojima, Chem. Asian J. 6, 674-680 (2011). [Special issue for
Eiichi Nakamura].

“Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents”, K. Kumar, D. Awasthi,
S.-Y. Lee, I. Zanardi, W. Berger, B. Ruzsicska, P. J. Tonge, S. E. Knudson, R. A. Slayden, I. Ojima, J. Med. Chem. 54,
374-381 (2011).

“Design and synthesis of de novo cytotoxic alkaloids by mimicking the bioactive conformation of paclitaxel”, L. Sun, J.
M. Veith, P. Pera, R. J. Bernacki and I. Ojima, Bioorg. Med. Chem. 18, 7101-7112 (2010).

“New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified
colon tumor-initiating cells”, G. I Botchkina, H. Wang, S. Zhu, Y. Wang, A. G Savitt, R. A Rowehl, Y. Leyfman, J. Ju,
M. Das, E. Zuniga and I. Ojima, Mol. Cancer 9:192 online (2010).

“Mechanism-Based Tumor-Targeting Drug Delivery System. Validation of Efficient Vitamin Receptor-Mediated
Endocytosis and Drug Release”, S. Chen, X. Zhao, J. Chen, J. Chen, S. S. Wong and I. Ojima, Bioconjugate Chem., 21,
979-987 (2010). PMID: 20429547;

“Cell death induced by novel fluorinated taxanes in drug-sensitive and drug-resistant cancer cells”, J. Vobořilová, V.
Němcová-Fürstová, J. Neubauerová, I. Ojima, I. Zanardib, I. Gut, J. Kovář, Invest. New Drugs, 29, 2951–2960 (2009).

“Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells”, Kovár J,
Ehrlichová M, Smejkalová B, Zanardi I, Ojima I, Gut I. Anticancer Res. 29, 2951-60 (2009).

“One-step Formation of Fused Tetracyclic Skeletons from Cyclohexene-diynes and Carbon Monoxide through
Rh(I)-Catalyzed [2+2+2+1] Cycloaddition Reaction”, J. J. Kaloko, Y.-H. G. Teng and I. Ojima, Chem. Commun.
4569-4571 (2009).

“Efficient Syntheses of Crispine A and Harmicine by Rh-Catalyzed Cyclohydrocarbonylation”, W.-H. Chiou, C.-C. Hsu,
G.-H. Lin, S. J. Chaterpaul, and I. Ojima, Org. Lett. 11, 2659-2662 (2009).

“Novel C-seco-taxoids possessing high potency against paclitaxel-resistant cancer cell lines overexpressing class III
β-tubulin”, A.Pepe, L. Sun, I. Zanardi, X. Wu, C. Ferlini, G. Fontana, E. Bombardelli, and I. Ojima, Bioorg. Med. Chem.
Lett., 19 3300-3304 (2009).