Recent Presentations

List of Recent Presentations

1.              Ojima, I. New generation anti-​TB drug discovery targeting Mtb-​FtsZ. Abstracts of Papers of the American Chemical Society 248 (2014).

2.              Wang, T.; Teng, Y. G.; Wei, L.; Ojima, I. Design, synthesis, and development of a novel PAMAM-​based bow-​tie dendrimer platform for tumor-​targeting drug delivery. Abstracts of Papers of the American Chemical Society 248 (2014). 

3.              Haranahalli, K.; Awasthi, D.; Kumar, K.; Knudson, S.; Goullieux, L.; Carreau, A.; Fraisse, L.; Vermet, H.; Klieber, S.; Slayden, R. A.; Ojima, I. Trisubstituted benzimidazoles as a new class of antitubercular agents targeting FtsZ with high in vitro activity and in vivo efficacy.  Abstracts of Papers of the American Chemical Society 248 (2014).

4.             Tong, S.; Haranahalli, K.; Awasthi, D.; Kumar, K.; Knudson, S.; Slayden, R. A.; Ojima, I. SAR study for the lead optimization of trisubstituted benzimidazoles as new-​generation antitubercular agents, targeting FtsZ. Abstracts of Papers of the American Chemical Society 248 (2014).

5.             Chen, S.; Chien, C.; Ojima, I. Preparation of ortho-​phenylenetriynes for rapid access to novel colchicinoids through Rh-​catalyzed [2+2+2+1] cycloaddition. Abstracts of Papers of the American Chemical Society 248 (2014). 

6.             Vineberg, J. G.; Wang, T.; Seitz, J. D.; Fowler, J. S.; Ojima, I. Development of robust tumor-​targeted drug delivery system (TTDDS) platform and its applications to novel taxane-​based drug conjugates with biotin as the tumor-​targeting module. Abstracts of Papers of the American Chemical Society 247 (2014).   

7.             Wei, L.; Lazo, E. O.; Awasthi, D.; Chowdhury, S. R.; Jakoncic, J.; Ojima, I. Computational and structural biology approaches to the identification of potential binding sites of novel benzimidazole inhibitors with Mtb-​FtsZ for antitubercular drug discovery. Abstracts of Papers of the American Chemical Society 247 (2014).

8.             Zhou, Y.; Teng, Y. G.; McGillick, B. E.; Swaminathan, S.; Ojima, I.; Rizzo, R. C. Computational approaches for targeting botulinum neurotoxins. Abstracts of Papers of the American Chemical Society 247 (2014).

9.             Wang, T.; Teng, Y. G.; Wei, L.; Li, W.; Ojima, I. Synthesis and biological evaluation of novel asymmetric bow-​tie PAMAM dendrimer-​based tumor-​targeting drug conjugates. Abstracts of Papers of the American Chemical Society 246 (2013).

10.           Haranahalli, K.; Kumar, K.; Awasthi, D.; Knudson, S.; Slayden, R. A.; Ojima, I. Lead optimization of novel benzimidazoles for efficacious antitubercular agents targeting FtsZ. Abstracts of Papers of the American Chemical Society 246 (2013).

11.           Vineberg, J.G., Zuniga, E.S., Fowler, J.S. & Ojima, I. Taxoid-based tumor-targeting chemotherapeutic agents bearing an imaging module. Abstracts of Papers of the American Chemical Society 245 (2013).

12.           Seitz, J.D. & Ojima, I. Design and synthesis of a novel taxoid for radiolabeling studies of tumor-targeted drug conjugates. Abstracts of Papers of the American Chemical Society 245 (2013).

13.           Park, B. et al. Design, synthesis, and evaluation of novel trisubstituted benzimidazoles targeting FtsZ as antimicrobial agents. Abstracts of Papers of the American Chemical Society 245 (2013).

14.           Awasthi, D. et al. Synthesis and biological evaluation of novel antitubercular trisubstituted benzimidazoles targeting FtsZ. Abstracts of Papers of the American Chemical Society 245 (2013).

15.           Zheng, S.Q. et al. Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents. Abstracts of Papers of the American Chemical Society 244 (2012).

16.           Zang, Y. & Ojima, I. Pd-catalyzed asymmetric allylic etherification using chiral biphenol-based diphosphonite ligands and its application for the formal total syntheses of (-)-galanthamine. Abstracts of Papers of the American Chemical Society 244 (2012).

17.           Wang, T., Teng, G.Y.H. & Ojima, I. Synthesis of a novel asymmetrical bow-tie PAMAM dendrimer-based drug conjugate bearing biotin and a second-generation taxoid. Abstracts of Papers of the American Chemical Society 244 (2012).

18.           Vineberg, J.G., Zuniga, E.S. & Ojima, I. Synthesis and biological evaluation of novel dual-warhead tumor-targeting drug conjugates bearing a taxoid and a camptothecin. Abstracts of Papers of the American Chemical Society 244 (2012).

19.           Seitz, J.D. et al. Preclinical evaluation of PUFA conjugates of next generation taxoid SB-T-1214. Abstracts of Papers of the American Chemical Society 244 (2012).

20.           Lin, C.F., Chien, C.W. & Ojima, I. Asymmetric synthesis of an advanced key intermediate to (-)-Huperzine A via Pd-catalyzed intermolecular tandem allylic alkylation using chiral biphenol-based phosphoramidites. Abstracts of Papers of the American Chemical Society 244 (2012).

21.          Kumar, K. et al. Design, synthesis, optimization, and biological evaluation of novel trisubstituted-benzimidazoles as efficacious antitubercular and antimicrobial agents, targeting FtsZ. Abstracts of Papers of the American Chemical Society 244 (2012).

22.          Kamath, B.A., Das, M., Kuznetsova, L., Longtin, J. & Ojima, I. Functionalized-SWNT as a versatile platform for tumor-targeted drug delivery and dual therapy. Abstracts of Papers of the American Chemical Society 244 (2012).

23.          Chien, C.W., Athan, A.A., Teng, Y.H.G. & Ojima, I. Rapid access to novel colchicinoids through Rh-catalyzed 2+2+2+1 cycloaddition of ortho-phenylenetriynes. Abstracts of Papers of the American Chemical Society 244 (2012).

24.          Berger, W.T. et al. Synthesis and biological evaluation of novel DARPin-PEG(3)-SB-T-1214 bioconjugates targeting CD-326 (EpCAM). Abstracts of Papers of the American Chemical Society 244 (2012).

25.          Athan, A.A., Lin, C.F., Kaloko, J.J., Teng, G.Y.H. & Ojima, I. Formation of 5-7-7-5 tetracycles and 5-7-5 tricyclic gama-lactams via Rh-catalyzed 2+2+2+1 cycloaddition of enediynes. Abstracts of Papers of the American Chemical Society 244 (2012).

 


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Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400 Phone: (631) 632-7890
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