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Faculty of the Genetics Program by Department

 

Anesthesiology

Dubnau, JoshLearning, memory, genetics, and behavior

Enikolopov, Grigori, Stem cells, neurogenesis, and signal transduction

 

Biochemistry and Cell Biology

Bingham, Paul, Novel approaches to cancer chemotherapy; genetic control of development and gene expression in animals

Citovsky, Vitaly, Genetic transformation, intercellular transport, and chromatin remodeling in plants

Gergen, J. Peter, Transcriptional regulation in Drosophila

Hu, Chi-Kuo, The biology of dormancy and its interaction with development and aging

Karzai, A. Wali, Structure and function of RNA-binding proteins; SmpB-SsrA quality control system

Luk, Ed, Cellular organization of chromatin structure for accommodation and control of gene expression

Martin, Benjamin, Stem cell maintenance and differentiation; developmental mechanisms of cancer pathogenesis

Matus, David, Evolutionary, cellular, and developmental study of nematode uterine-vulval attachment and morphogenesis

Neiman, Aaron, Vesicle trafficking and membrane-cytoskeletal interactions

Nelson, Jonathan,  Understanding the impact of retrotransposons and repetitive DNA maintenance in germline genome stability

Pisconti, Dada, Muscle stem cells; muscular dystrophy; muscle development; muscle regeneration; muscle aging; extracellular matrix; biology of proteoglycans

Thomsen, Gerald, The transforming growth factor-ß family in embryonic development

Zachar, Zuzana, Cancer chemotherapy drug discovery

 

Ecology and Evolution

Davalos, Liliana, Environmental change and its relationship to phylogeny, population genetics, and biodiversity conservation

Eanes, Walter, Molecular evolution and phylogenetic analysis

Rest, Joshua, Computational, comparative, and experimental approaches to study linkage of genotype and phenotype

True, John, Evolutionary genetics in Drosophila

Veeramah, Krishna, Evolutionary genomics

 

Family, Population, and Preventive Medicine

Williams, Jennie, Cancer chemotherapuetics; cancer health disparity; tumor biology; chemoresistance/chemoresponse in racial and ethnic populations

 

Medicine

Bahou, Wadie,Genetic disorders of hemostasis and thrombosis

Bialkowska, Agnieszka, Acute and chronic pancreatitis; pancreatic cancer; animal models; pancreatic stromal and immune cell interactions,;single-cell and bulk next-generation sequencing

Ghebrehiwet, Berhane, Structure-function of C1q receptors and their role in infection, inflammation, and cancer

Hannun, YusufMechanisms and functions of bioactive sphingolipids in cancer

 

Microbiology and Immunology

Carpino, Nicholas, Positive and negative regulation of T cell receptor signaling

Carter, Carol A., Retroviral assembly and post-assembly events

Del Poeta, Maurizio, Sphingolipid metabolism and signaling in fungal and mammalian cells

Futcher, A. Bruce, Cancer, cell cycle, cyclins, microarrays, computational biology, and yeast genetics

Hearing, Patrick, Adenovirus regulation of cellular proliferation and; adenovirus vectors for human gene therapy

Kim, Hwan, Rickettsial pathogenesis and vaccine assembly for tick-borne rickettsioses

Konopka, James, Genetic analysis of the fungal pathogen Candida albicans

Krug, Laurie, Virus-host interactions during chronic γherpesvirus infection

Mackow, Erich, Rotavirus and hantavirus genetics and pathogenesis

Reich (Marshall), Nancy, Signaling switches in gene expression by hormones or viral infection

Sheridan, Brian, Mucosal immunology; T cell memory; vaccine design; host-pathogen interactions

Thanassi, David, Secretion of bacterial virulence factors and their roles in pathogenesis

Van der Velden, Adrianus, The mammalian T cell response to Salmonella enterica serovar Typhimurium

 

Neurobiology and Behavior

Ge, Shaoyu, Functional integration of new neurons into brain circuits

Kernan, Maurice, Mechanical senses in Drosophila; ciliary signaling

Kritzer, Mary, Effects of the gonadal hormones on the structure, biochemistry, and function of the cerebral cortex

Shelly, Maya, Molecular mechanisms of embryonic brain development; axon regeneration; neurodegenerative disorders

Sher, Roger, Neurobiology; neurodegenerative diseases; amyotrophic lateral sclerosis; Alzheimer's; dementias

Sirotkin, Howard, Specification and patterning of the neural plate; vertebrate developmental genetics

 

Pathology

Chen, Jiang, Planar cell polarity and primary cilia in skin and hair follicle development and skin cancers

Chung, Jun, Mechanisms of tumor invasion and metastasis

Damaghi, Medhi, Tumor evolution in its microenvironment using single-cell multi omics and spatial omics connecting genotype to phenotype

Furie, Martha B., Interactions of bacterial pathogens with host cells of innate immunity

Ju, Jingfang, miRNAs in proliferation, cell-cycle control, chemoresistance of tumor stem cells, and epithelial-to-mesenchymal transition

Martinez, Luis, Gain of function of mutant p53 oncogene

Moll, Ute, The p53/p73/p63 gene family in human cancer; transcription-independent mitochondrial apoptosis program of p53

Powers, R. Scott, Cancer gene discovery; cancer diagnostics and therapeutics; cancer biology

Shroyer, Kenneth, Molecular characterization of benign, premalignant, and malignant lesions of the female genital tract

Talos, Flaminia, Intra-tumor heterogeneity in prostate cancer; tissue reprogramming in the urinary bladder

 

Pharmacological Sciences

Bogenhagen, Daniel, Mitochondrial molecular biology

Brownlee, Christopher, Molecular mechanisms of spindle orientation, ciliogenesis, polarity, actin cortex formation, and axonogenesis

Colognato, Holly, Extracellular matrix in the brain: roles during development and neurodegeneration

Demple, Bruce, Cellular systems to counteract oxidative damage

Frohman, Michael, Lipid signaling in normal physiology, diabetes, and cancer

Kim, Hyungjin, Mechanisms of mammalian DNA replication and repair in cancer development and therapy

Malbon, Craig, Signal transduction in differentiation and development: roles of molecular scaffold molecules

Rahme, Gilbert, Cancer epigenetics with a focus on brain tumors

Seeliger, Jessica, Mechanisms of cell wall and membrane assembly in Mycobacterium tuberculosis

Seeliger, Markus, Molecular mechanisms of protein kinase and ubiquitin ligase signaling in cancer and aging

Takemaru, Ken-Ichi, Cell signaling and ciliogenesis in mammalian development, health, and disease

Tsirka, Styliana-Anna, Cross-talk between the nervous and immune systems in health and disease

Wan, Ledong, RNA metabolism; inflammation; cancer

 

Physiology and Biophysics

Acosta-Martinez, Maricedes, Neuroendocrine regulation of the hypothalamus-pituitary-gonad (HPG) axis

Cheung, Leonard, Genetic control of pituitary cell fate throughout life using animal and pluripotent cell models and single-cell technologies

Lin, Richard, Physiological functions and pathological roles of phosphoinositide 3-kinases (PI3Ks)

Luberto, Chiara, Sphingolipid metabolism and signaling

White, Thomas, Gap junction functions defined by genetic diseases and gene knockouts

 

Psychology

Canli, Turhan, Genomic imaging of emotion, personality, and individual differences

 

Brookhaven National Laboratory

Freimuth, Paul, Virus-receptor interactions

 

Cold Spring Harbor Laboratory

Amor Vegas, Corina, Cellular senescence and immune surveillance in cancer and aging 

Beyaz, Semir, Dietary regulation of immunity and cancer; epigenetics; metabolism

Cheadle, Lucas, Neuro-immune mechanisms of brain development and disease

Dobin, Alexander, Computational multi-omics; biological big data; bioinformatics tools

dos Santos, Camila, Epigenetic dependencies of normal and malignant breast development; gene expression in prevention and treatment of cancer

Egeblad, Mikala, Tumor microenvironment, tumor-associated myeloid cells, and breast cancer

Fearon, Douglas, Cancer immunology; immunotherapy; host response to cancer

Gingeras, Thomas, Genome-wide organization of transcription and functional roles of non-protein coding RNAs

Hammell, Christopher, Genetic regulation of temporal development and the function of animal microRNAs

Hammell, Molly, Computational and functional genomics; control of transposable elements; neurodegenerative disease

Jackson, David, Plant development; stem cell signaling; genomics and imaging

Janowitz, Tobias, Host response to cancer: metabolic, endocrinological, neurological, and immunological consequences and treatment strategies in cancer medicine

Joshua-Tor, Leemor, Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography

Koo, Peter, Computational biology; artificial intelligence; interpretable deep learning for genomics

Krainer, Adrian R., Posttranscriptional control of gene expression; pre-mRNA splicing mechanisms, fidelity and genetic diseases

Li, Bo, Glutamatergic synapses; synaptic plasticity; schizophrenia; depression; rodent models of psychiatric disorders

Lukey, Michael, Metabolic reprogramming during tumorigenesis and metastasis

Martienssen, Robert, Epigenetics; chromatin and chromosome biology; stem cells; plant genomics; plant evolution; aquatic plants

McCombie, Richard, Genomics of psychiatric disorders; genomics of cancer; computational genomics; plant genomics

Meyer, Hannah, Tolerance induction and generation of diversity in the developing immune system; systems immunology; transcriptomics; bioinformatics

Mills, Alea, Cancer; development; aging; senescence; epigenetics; autism

Pedmale, Ullas, Organism-environment interactions; photobiology; signal transduction; genomics; cellular growth; decision-making in plants

Schorn, Andrea,  Non-coding and small RNA; transposable elements; stem cells; epigenetics

Sheltzer, Jason, Consequences of aneuploidy and gene dosage imbalances in development and cancer

Siepel, Adam, Computational biology; population genetics; computational genomics; molecular evolution; transcriptional regulation

Spector, David, Cell biology; gene expression; nuclear structure; non-coding RNAs

Stillman, Bruce, Cancer; cell cycle; DNA replication; chromatin assembly; biochemistry; yeast genetics

Tollkuhn, Jessica, Regulation of gene expression in the brain by estrogen and testosterone

Tonks, Nicholas, Posttranslational modification; phosphorylation; phosphatases; signal transduction; protein structure and function

Trotman, Lloyd, Cancer modeling and treatment; senescence and tumor progression; cancer visualization; PTEN regulation

Tuveson, David, Pancreatic cancer; experimental therapeutics; diagnostics; mouse models; cancer genetics

Vakoc, Christopher, Transcriptional regulation of mammalian cell growth

Van Aelst, Linda, Signal transduction; Ras and Rho proteins; tumorigenesis; neuronal development

Westcott, Peter,  Cancer genomics and immunology; Evolution of immune surveillance and dysfunction during cancer progression and metastasis

Zhang, Lingbo, Normal and malignant stem and progenitor cells; self-renewal; metabolism; therapeutic targets