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Faculty of the Genetics Program by Department

 

Anesthesiology

Enikolopov, Grigori, Stem cells, neurogenesis, and signal transduction

 

Applied Mathematics and Statistics

MacCarthy, Thomas, Computational immunology and evolutionary systems biology

 

Biochemistry and Cell Biology

Bingham, Paul, Novel approaches to cancer chemotherapy; genetic control of development and gene expression in animals

Brown, Deborah, Function of lipid rafts; endocytosis

Citovsky, Vitaly, Genetic transformation, intercellular transport, and chromatin remodeling in plants

Czaplinski, Kevin, Post-transcriptional control of gene expression in the nervous system

Gergen, J. Peter, Transcriptional regulation in Drosophila

Hollingsworth, Nancy, Chromosome behavior in meiosis

Karzai, A. Wali, Structure and function of RNA-binding proteins; SmpB-SsrA quality control system

Levy, Sasha, Evolutionary dynamics; network dynamics; yeast genomics; high-throughput technology development

Luk, Ed, Cellular organization of chromatin structure for accommodation and control of gene expression

Martin, Benjamin, Stem cell maintenance and differentiation; developmental mechanisms of cancer pathogenesis

Matus, David, Evolutionary, cellular, and developmental study of nematode uterine-vulval attachment and morphogenesis

Neiman, Aaron, Vesicle trafficking and membrane-cytoskeletal interactions

Smith, Steven O., Structure and function of membrane proteins

Sternglanz, Rolf, Proteins and enzymes affecting chromatin

Thomsen, Gerald, The transforming growth factor-ß family in embryonic development

Zachar, Zuzana, Cancer chemotherapy drug discovery

 

Ecology and Evolution

Davalos, Liliana, Environmental change and its relationship to phylogeny, population genetics, and biodiversity conservation

Eanes, Walter, Molecular evolution and phylogenetic analysis

Henn, Brenna, Human evolution, population genetics, and genomics

Rest, Joshua, Computational, comparative, and experimental approaches to study linkage of genotype and phenotype

True, John, Evolutionary genetics in Drosophila

Veeramah, Krishna, Evolutionary genomics

 

Internal Medicine

Bahou, Wadie, Genetic disorders of hemostasis and thrombosis

Cao, Jian, Cancer cell invasion and migration; anti-cancer drug discovery

Ghebrehiwet, Berhane, Structure-function of C1q receptors and their role in infection, inflammation, and cancer

Kaushansky, Kenneth, Gene expression, growth control, hematopoesis, megakaryocyte development, and stem cell transplantation

 

Molecular Genetics and Microbiology

Benach, Jorge, Pathogenesis of bacterial infections

Bliska, James B., Molecular and cellular basis of bacterial-host cell interactions; pathogenesis

Carpino, Nicholas, Positive and negative regulation of T cell receptor signaling

Carter, Carol A., Retroviral assembly and post-assembly events

Del Poeta, Maurizio, Sphingolipid metabolism and signaling in fungal and mammalian cells

Futcher, A. Bruce, Cancer, cell cycle, cyclins, microarrays, computational biology, and yeast genetics

Hearing, Patrick, Adenovirus regulation of cellular proliferation and; adenovirus vectors for human gene therapy

Konopka, James, Cell growth and development in yeast; G protein signal transduction

Krug, Laurie, Virus-host interactions during chronic γherpesvirus infection

Leatherwood, Janet, Cell cycle control of replication and gene expression; control of meiotic differentiation

Mackow, Erich, Rotavirus and hantavirus genetics and pathogenesis

Reich (Marshall), Nancy, Signaling switches in gene expression by hormones or viral infection

Sheridan, Brian, Mucosal immunology; T cell memory; vaccine design; host-pathogen interactions

Thanassi, David, Secretion of bacterial virulence factors and their roles in pathogenesis

Van der Velden, Adrianus, The mammalian T cell response to Salmonella enterica serovar Typhimurium

Wimmer, Eckard, Molecular biology of poliovirus replication and basis of picornaviral pathogenesis

Zong, Wei-Xing, Molecular regulation of apoptotic and necrotic cell death

 

Neurobiology and Behavior

Ge, Shaoyu, Functional integration of new neurons into brain circuits

Kernan, Maurice, Mechanical senses in Drosophila; ciliary signaling

Kritzer, Mary, Effects of the gonadal hormones on the structure, biochemistry, and function of the cerebral cortex

Shelly, Maya, Molecular mechanisms of embryonic brain development; axon regeneration; neurodegenerative disorders

Sirotkin, Howard, Specification and patterning of the neural plate; vertebrate developmental genetics

 

Pathology

Chen, Jiang, Planar cell polarity and primary cilia in skin and hair follicle development and skin cancers

Chung, Jun, Mechanisms of tumor invasion and metastasis

Furie, Martha B., Interactions of bacterial pathogens with host cells of innate immunity

Girnun, Geoffrey, Metabolic control of hepatocellular carcinoma by PGC1α; PPARγ coactivation in obesity and colon cancer

Ju, Jingfang, miRNAs in proliferation, cell-cycle control, chemoresistance of tumor stem cells, and epithelial-to-mesenchymal transition

Martinez, Luis, Gain of function of mutant p53 oncogene

Moll, Ute, The p53/p73/p63 gene family in human cancer; transcription-independent mitochondrial apoptosis program of p53

Powers, R. Scott, Cancer gene discovery; cancer diagnostics and therapeutics; cancer biology

Shroyer, Kenneth, Molecular characterization of benign, premalignant, and malignant lesions of the female genital tract

Talos, Flaminia, Intra-tumor heterogeneity in prostate cancer; tissue reprogramming in the urinary bladder

 

Pediatrics

Bhaduri-McIntosh, Sumita, Pediatrics; Molecular Genetics & Microbiology.  Interactions of the immune system with Epstein-Barr virus

 

Pharmacological Sciences

Aguirre, Adan, Endogenous NG2-progenitor cells ('neural stem cells') for cell-based replacement in brain diseases

Bogenhagen, Daniel, Mitochondrial molecular biology

Chan, Chia-Hsin (Lori), Molecular mechanisms of cancer development; cancer metabolism and stemness

Colognato, Holly, Extracellular matrix in the brain: roles during development and neurodegeneration

Demple, Bruce, Cellular systems to counteract oxidative damage

Frohman, Michael, Lipid signaling in normal physiology, diabetes, and cancer

Malbon, Craig, Signal transduction in differentiation and development: roles of molecular scaffold molecules

Seeliger, Markus, Molecular mechanisms of protein kinase and ubiquitin ligase signaling in cancer and aging

Takemaru, Ken-Ichi, Cell signaling and ciliogenesis in mammalian development, health, and disease

Tsirka, Styliana-Anna, Cross-talk between the nervous and immune systems in health and disease

 

Physiology and Biophysics

Acosta-Martinez, Maricedes, Neuroendocrine regulation of the hypothalamus-pituitary-gonad (HPG) axis

Lin, Richard, Physiological functions and pathological roles of phosphoinositide 3-kinases (PI3Ks)

Luberto, Chiara, Sphingolipid metabolism and signaling

White, Thomas, Gap junction functions defined by genetic diseases and gene knockouts

 

Psychology

Canli, Turhan, Genomic imaging of emotion, personality, and individual differences

 

Brookhaven National Laboratory

Freimuth, Paul, Virus-receptor interactions

 

Cold Spring Harbor Laboratory

Dubnau, Josh, Learning, memory, genetics, and behavior

Egeblad, Mikala, Tumor microenvironment, tumor-associated myeloid cells, and breast cancer

Gingeras, Thomas, Genome-wide organization of transcription and functional roles of non-protein coding RNAs

Hammell, Christopher, Genetic regulation of temporal development and the function of animal microRNAs

Huang, Z. Josh, Development and function of the GABAergic inhibitory circuitry in neocortex; neurogenomics; autism

Jackson, David, Plant development; stem cell signaling; genomics and imaging

Joshua-Tor, Leemor, Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography

Krainer, Adrian R., Posttranscriptional control of gene expression; pre-mRNA splicing mechanisms, fidelity and genetic diseases

Lee, Jay, Functional genomics; spatial reconstruction of gene expression and cell lineage information; technology development

Li, Bo, Glutamatergic synapses; synaptic plasticity; schizophrenia; depression; rodent models of psychiatric disorders

Lyon, Gholson, Human genetics; neuropsychiatric diseases; whole-genome sequencing

Martienssen, Robert, Epigenetics; chromatin and chromosome biology; stem cells; plant genomics; plant evolution; aquatic plants

McCombie, Richard, Genomics of psychiatric disorders; genomics of cancer; computational genomics; plant genomics

Mills, Alea, Cancer; development; aging; senescence; epigenetics; autism

Schatz, Michael, Genomics; genome assembly and validation; sequence alignment; high performance and multicore computing

Sheltzer, Jason, Consequences of aneuploidy and gene dosage imbalances in development and cancer

Siepel, Adam, Computational biology; population genetics; computational genomics; molecular evolution; transcriptional regulation

Sordella, Rafaella, Molecular therapeutics; signal transduction

Spector, David, Cell biology; gene expression; nuclear structure; non-coding RNAs

Stillman, Bruce, Cancer; cell cycle; DNA replication; chromatin assembly; biochemistry; yeast genetics

Tonks, Nicholas, Posttranslational modification; phosphorylation; phosphatases; signal transduction; protein structure and function

Trotman, Lloyd, Cancer modeling and treatment; senescence and tumor progression; cancer visualization; PTEN regulation

Tuveson, David, Pancreatic cancer; experimental therapeutics; diagnostics; mouse models; cancer genetics

Vakoc, Christopher, Transcriptional regulation of mammalian cell growth

Van Aelst, Linda, Signal transduction; Ras and Rho proteins; tumorigenesis; neuronal development

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