Research Cafe


 Daphne Meza

Daphne Meza

PhD candidate in the Department of Biomedical Engineering

'Understanding the Mechanobiology behind Atherosclerosis Formation'

Synopsis: Atherosclerosis formation in the coronary arteries is the main cause of Coronary Artery Disease (CAD), which is the leading cause of death in the US.  Coronary arteries are subject to various mechanical stresses/strains, including blood flow induced shear stress and blood vessel motion (dilation, contraction, and bending) induced tensile (or compressive) stress/strain.  It has been well documented that mechanical stress/strain plays an important role in regulating vascular endothelial cell physiology, function, and the pathological development of vascular diseases such as atherosclerosis. My work focuses on understanding how these different mechanical conditions work together to regulate multiple aspects of vascular physiology, function, and disease initiation. A better understanding of this process can lead to more targeted preventive and therapeutic solutions for cardiovascular diseases.

Biography: Daphne was born and raised in Honduras. She completed her bachelor’s degree in mechanical engineering at the University of New Orleans where she participated in three biomedical research internships at Brookhaven National Laboratory during the summer months. That research experience brought her here to Stony Brook, where she is continuing her work in the biomedical sciences. Her PhD dissertation focuses on understanding the impact pathological hemodynamics has on atherosclerosis formation. Daphne is an AGEP-T FRAME, Bridge to the Doctorate, Turner and GEM Fellow.


Wednesday, July 27, 2016 at 12:00 PM



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