PhD Candidate in the Department of Molecular & Cellular Biology
'The Role of Dystrophin in Myelination of the Central Nervous System'
Synopsis: Along with severe muscle atrophy, Duchenne muscular dystrophy (DMD), which is caused by mutations in the dystrophin gene, also results in attention/learning disabilities, seizures and other kinds of cognitive impairments; however, the cellular dysfunction triggering these brain impairments remains unknown. Myelination is critical for the speed and coordinated timing required for all complex nervous system function, however, it also remains unknown if oligodendrocytes, the myelinating cells of the brain, contain dystrophin, and if so, whether it is required for normal oligodendroglial development. Here we will determine if oligodendrocytes have both dystrophin and an associated dystrophin-associated glycoprotein complex (DGC) that contribute to successful myelination and brain function.
Biography: Azeez Aranmolate earned his undergraduate degree in biology at Brandeis University. He chose biology because he found living organisms and nature to be fascinating. As a Turner and AGEP-T FRAME Fellow at Stony Brook University, Aranmolate is pursuing his PhD in Molecular and Cellular Biology and conducting research in the lab of Dr. Holly Colognato.
Monday, November 16, 2015 at 12:00 PM