PhD Candidate in Molecular and Cellular Biology
'PI3K p110β Maintains Bioenergetic Homeostasis by Regulating Endocytic
Synopsis: Nutrient sensing and uptake is essential for cellular catabolic and anabolic processes and is tightly regulated in response to growth factor availability. The aberrant trafficking of nutrient transporters can facilitate nutrient uptake, often associated with oncogenic transformation. We show that the PI3K p110β catalytic subunit functions as a positive regulator for endocytic turnover of glucose transporter 1 (GLUT1). Cells deficient in p110β fail to internalize GLUT1 during growth factor starvation and correlates with increased glucose metabolism. This metabolic reprogramming may be important for the oncogenic potential seen in cells lacking p110β. Thus, p110β is an important regulator of bioenergetics homeostasis by regulating the Rab5-associated endocytic turnover of nutrient transporters.
Biography: Jennifer DeLeon is a PhD candidate in the program for molecular and cellular biology in the laboratory of Dr. Wei-Xing Zong. Her thesis work shows the relationship between signaling enzymes and cancer cell metabolism. She is also the founder of the MCB Department Research Newsletter and co-founder of the PhD Career Ladder Program. Jennifer is an active member of the Center for Inclusive Education; she is a Turner Fellow, participates in the Community of Student Mentors Program and teaches a research methods course for incoming summer interns.