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Diana Guimet   

Diana Guimet

Ph.D. Candidate in the Department of Molecular Genetics and Microbiology

The Adenovirus L4-22K Protein has Distinct Functions in Post-transcriptional Regulation of Gene Expression and Encapsidation of the Viral Genome

  

Synopsis: Adenovirus (Ad) infection is generally associated with mild respiratory, gastrointestinal diseases, or ocular diseases, but recently, Ad has been recognized as an important pathogen in immunocompromised individuals. Recombinant Ad vectors are being utilized in ~25% of current human gene therapy trials. There is no virus-specific therapy for Ad infection and there is still much to learn about the basic biology of Ads to construct engineered viruses for targeted therapies. Therefore, it has become increasingly important to understand the molecular mechanisms of the viral life cycle. My research focuses on the L4-22K virus encoded protein of human Ad5 serotype. Since the L4-22K protein serves as the master regulator to coordinate late gene expression and is essential for Ad genome encapsidation, this protein may serve as a useful target for antiviral therapy.  

Biography: Diana Guimet is from San Diego, California. She received her Undergraduate degree in Biology from the University of San Diego in 2007 and joined the Genetics program at Stony Brook in 2009 as a SUNY STEM Diversity fellow, then became a Turner Fellow, and is currently an AGEP-T Frame fellow. She has also earned the prestigious Department of Molecular Genetics and Microbiology award for Outstanding Scientific Achievement by a Graduate Student.

 

Wednesday, September 10th at 12:30pm

rsvp

 

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