Eszter Boros, Assistant Professor, starting Fall 2017
M.S. University of Zurich, 2007
Ph.D. University of British Columbia, 2011
Postdoctoral Fellow at Harvard Medical School/ MGH, 2011-2015
The Boros Group Website
In our lab, we harness the rich structural diversity of metal complexes paired with
their versatile luminescent and radioactive properties for the design of new metal-based
molecular imaging probes and therapeutics for personalized medicine. We are interested
in developing probes for the following applications:
Imaging and treatment of bacterial infections with siderophores
Antibiotic resistance is an imminent global health threat. Accelerated diagnosis and
new life-saving treatments are needed to overcome resistance. Most pathogens have
developed sophisticated mechanisms to sequester the essential metal ion Fe(III) from
their host. This process involves Fe(III) chelators called siderophores. Naturally
occurring and synthetic siderophores can act as Trojan horses to deliver antibiotics
to the site of infection. These conjugates are referred to as sideromycins. We are
exploring sideromycins as new therapeutic and imaging tools for the treatment of bacterial
Metal-based probes for the multimodal imaging of cancer
The prognosis and survival of patients with aggressive cancers depends on the presence
of positive tumor margins (defined as the presence of tumor cells in the surrounding
area) post surgical resection. Combining radioactive and luminescent reporters in
a targeted molecular probe has the potential to provide pre-operative nuclear imaging,
real-time luminescence-guided surgery followed by ex vivo imaging with one single
probe. The goal of this project is the design, synthesis and evaluation of metal-based
bimodal probe systems that allow more thorough characterization of aggressive cancers
for improved treatment plans and outcome.
ImmunoPET probes for the imaging of pulmonary fibrosis
Idiopathic Pulmonary Fibrosis (IPF) is a fatal lung disease, with death occurring
on average within 3 years of diagnosis. IPF is markedly heterogeneous both in its
progression and pathogenesis. ImmunoPET imaging with radiolabeled antibodies and antibody
fragments could assess and monitor drug target abundance, target accessibility and
drug uptake in individual patients, which provides an invaluable tool for a personalized
medicine approach to IPF. For this purpose, we label antibodies targeting and inhibiting
pro-fibrotic pathways with positron emitters using optimized radiolabeling and immunoconjugation
techniques. The output of this work will be an immunoPET probe for pulmonary fibrosis
that can be translated clinically, as well as improved radiolabeling technology for
general immunoPET applications.
Work in our lab is multidisciplinary and encompasses: Organic and inorganic chemical
synthesis, radiochemistry, analytical chemistry, biological chemistry, in vitro and
in vivo imaging. We are interested in exploring and understanding the structure-activity
relationships of the metal complexes we synthesize, placing us in the realm of medicinal
chemistry with an inorganic twist!
Meimetis LG, Boros E, Carlson JC, Ran C, Caravan P, Weissleder, R. Bioorthogonal Fluorophore
Linked DFO-Technology Enabling Facile Chelator Quantification and Multimodal Imaging
of Antibodies. Bioconjugate Chem. 2016, 27, 257-63.
Boros E, Bowen AM, Josephson L, Vasdev N, Holland JP. Chelate-free metal ion binding and heat-induced radiolabeling of iron oxide nanoparticles. Chem. Sci. 2015, 1, 225-36.
Boros E, Rybak-Akimova, E, Holland J, Rietz TA, Rotile NJ, Blasi F, Day H, Latifi
R, Caravan P. Pycup – A bifunctional, cage-like ligand for 64Cu radiolabeling. Mol. Pharmaceutics. 2014, 11, 617–29.
Boros E, Polasek M, Zhang Z, Caravan P. Gd(DOTAla) – A single amino acid Gd-complex as a modular tool for high relaxivity
MR contrast agent development. J. Am. Chem. Soc. 2012, 134, 19858–68.
Boros E, Ferreira CL, Cawthray JF, Price EW, Patrick BO, Wester DW, Adam MJ, Orvig
C. Acyclic Chelate with Ideal Properties for 68Ga PET Imaging Agent Elaboration. J. Am. Chem. Soc. 2010, 132, 15726-33.
For complete publication list, click here.