Wen-Tien
Chen, Department of Medicine
& Subramanyam Swaminathan, Dept. of Biology, BNL
"Regulation
of Tumor Angiogenesis by Membrane Proteases."
The
long-term goal of this collaborative project is to understand the molecular
mechanisms that control extracellular matrix degradation on the surface of
endothelial cells during tumor angiogenesis. The specific aim of this seed
grant project is to obtain primary data on x-ray crystallography of recombinant
seprase at atomic resolution, which may lead to new approaches toward
identifying potential inhibitor and substrate-binding molecules for cell
surface seprase and its complexes as therapeutic agents in controlling
angiogenesis of human cancer.
Patricia
Coyle, Dept. of Neurology
& William Rooney, Dept. of Chemistry, BNL
"Blood
Brain Barrier Permeability and the Menstrual Cycle."
The goal of this pilot study is to examine blood brain barrier permeability
during the menstrual cycle. This study will involve control as well as women
suffering from Multiple Sclerosis in order to attempt to document blood brain
barrier impairment related to the menstrual cycle, and possible links to
relapses of MS disease activity.
Robert
Crease, Dept. of Philosophy, Historian, BNL
"Science
Studies at Stony Brook - a Plan for Interdisciplinary Program."
The continuation of a project begun last year, the funding will be used on
various activities designed to bolster the interest in the Science Study Forum.
These include a faculty reading seminar in science studies, a visiting lecture
series in science and ethics, a workshop of science studies, and the continuation
of the technoscience research seminar series.
Axel
Drees, Dept. of Physics
"Measurement
of Low Mass Electron Pairs Using the PHENIX Detector at RHIC."
The
focus of this project is the investigation of extending the scope of physics
accessible at Brookhaven National Lab's RHIC by the measurement of low mass
electron pairs. This could possibly lead to future upgrade possibilities of the
PHENIX equipment.
David
Ferguson, Director of CELT, Thomas Liao, Director of PEP
& Karl Swyler, Science Education Center, BNL
"A
Pre-Service 7-12 Science Teacher Development Program: Summer Research
Institute."
This
project seeks to enhance the training of pre-service teachers by building on
the academic priorities at Stony Brook and to improve the preparedness of
future college students. Summer institute activities hope to achieve these
goals by providing pre-service teachers with an inquiry-based research
experience that they can take back to the classroom with them.
Arie
Kaufman, Dept. of Computer Science
& Hong Ma, Dept. of Environmental Sciences, BNL
"Parallel
Volume Terrain Modeling and Rendering with Applications to Long Island Beach
Geomorphology"
The purpose of this project is to apply advanced parallel computing, terrain
modeling, and rendering techniques to gain a spatiotemporal understanding of
the geomorphic development of the Long Island coastline. This study will have
important applications in protecting our regional socioeconomic activities and
natural habitats from coastline erosion caused by storms and possible global
warning.
William
Lennarz, Dept. of Biochemistry
& Paul Freimuth, Dept. of Biology, BNL
"Recent
Advances in Proteomics - Joint SB/BNL Symposium on Molecular
Biology"
This grant will support the combined two-day symposium on Recent Advances in
Proteomics. Topics covered include: DNA and protein chip technologies,
protein-protein interactions and protein modifications, and structural and
computational aspects of proteomics.
Andreas
Mayr, Dept. of Chemistry
&
Bruce Brunschwig, Dept. of Chemistry, BNL
"Metal-Carbon Multiple Bonds as Building Blocks for
Molecular Materials"
This is a continuation of a project begun last year on the use of metal-carbon multiple bonds as functional and structural components in molecular materials. The development of molecular materials has become an active area of research, especially with regard to the potential to modify or even control the materials properties via the nature of molecular building blocks.
E.
Troy Rasbury, Dept. of Geosciences
& Antonio Lanzirotti, Dept. of Applied Science, BNL
"Use
of NSLS X-Ray Microprobe and FTIR Beam Lines to Evaluate the Distribution of
Trace Elements and Organic Materials in Caliche Paleosols."
This project is a microbeam/trace element study of calcite from soils at micron
resolution. This has implications for the determination of how areas
contaminated with radioactive waste should be cleaned up and how where such
waste should be stored.
Suzanne
Scarlata, Dept. of Physiology
& Biophysics John Sutherland, Dept. of Biology, BNL
"Role
of Lipid Membranes in the Initiation and Formation of Protein Synuclein
Fibrils."
This
project will study the processes involved in the binding of alpha-synucleins to
membranes. Alpha-Synuclein is of particular interest as it has been found to be
associated with Parkinson and Alzheimer Disease.
Wei
Zhao, Dept. of Radiology, Barbara Jacak, Dept. of Physics and
Astronomy
& Paul O'Connor and Bo Yu, Instrumental Division, BNL
"Investigating
the X-Ray Response of Photoconductors for Real-Time Flat-Panel Detectors in
Medical Imaging."
This project will investigate the properties of liquid xenon and
thick-deposition amorphous selenium in order to make improvements in
photoconduction materials. This could result in minimizing the exposure to
radiation during x-rays.
