Chemistry (Chemical Biology) Research Sponsors

ACADEMIC YEAR (Fall & Spring)

Faculty Sponsor   Course   Sect.   Research Interests

Boon, Elizabeth           Fundamentals and applications in biological sensing. Prokaryotic nitric oxide biology. Fundamentals and applications of the H-NOX family. Peptide and protein engineering for novel sensing applications.

Carrico, Isaac           Introduction of small molecules into biological systems for the purpose of tracking or perturbing cellular processes. Metabolic engineering. Protein engineering. Bioorthogonal reaction development.

Druekhammer, Dale           Computer-based design and synthesis of receptors and sensors for biomolecules. Design and synthesis of enzyme inhibitors. Enzyme reaction mechanisms

Fowler, Joanna           BNL: Biochemical effects of drugs, aging and selected diseases on the brain

Green, David           AMS: "How can macromolecular interactions be engineered in a rational manner to have the desired effects in a complex environment, such as a living organism?" Answering this question is a major focus of much of the work carried out in the Green Lab.

Johnson, Frank           PHARM: The major research interests of this laboratory are concerned with a) chemical aspects of genetic toxicology and b) a program of synthesis aimed at rationally designed drugs to inhibit viral enzymes associated with HIV-1 (AIDS), c) new methods of synthesis involving organo-alkali chemistry.

Laughlin, Scott           Our research uses chemistry to examine how the brain works. Neural synapse-crossing fluorophores. Fluorescent indicators of neural activity. Small molecule control of behavior.

London, Erwin           BIOCHEM: Our group is studying membrane protein structure and function by combining spectroscopic methods, such as fluorescence, with chemical, biochemical, immunochemical and molecular biological approaches.

Miller, Lisa      
  BNL: The study of the chemical makeup of cells and tissues using synchrotron-based infrared and x-ray imaging. Her work has three primary research areas: (1) understanding how the nanostructure and chemical composition of bone affect its mechanical properties in osteoarthritis and osteoporosis, (2) elucidating the role of metal ions in protein misfolding and neurodegeneration in Alzheimer's disease and amyotrophic lateral sclerosis, and (3) optimizing nutrient availability in the rhizosphere of plants for improved biomass production.

Ngai, Ming-Yu           The Ngai lab focuses on (i) developing novel and practical synthetic methodologies to address unmet challenges in organic synthesis and medicinal chemistry, and (ii) identifying and developing new radiotracers for Positron Emission Tomography (PET) imaging to elucidate disease mechanisms, identify drug targets, assess treatment efficacy, and accelerate drug discovery and development.

Ojima, Iwao           Design, synthesis, and structure-activity relationships of medicinally-active compounds, especially for the drug design and discovery of anticancer agents and antimicrobials. Development of new and efficient methods for the synthesis of biologically active compounds of medicinal interests.

Raleigh, Dan           Experimental studies of protein folding and amyloid formation.

Rizzo, Robert           AMS: The Rizzo Research Group employ computational techniques to drug discovery projects.  We are interested in both application and method development.  We use two primary tools: docking and molecular dynamics (MD). 

Rudick, Jon           Design and synthesis of bioactive oligomers, peptides and bioconjugates. Molecular recognition of biomacromolecules. Nanostructured materials for biotechnology applications (e.g., sensors and diagnostics).

Sampson, Nicole   BIO 487   T94   Bioorganic chemistry and mechanistic enzymology. Investigation of the structure and function of cholesterol oxidase protein-membrane interactions, and its relationship to Mycobacterium tuberculosis pathogenesis. Synthesis of peptides and polymers to probe the role of ADAM proteins in mammalian fertilization.

Scharer, Orlando           PHARM: Our research program combines organic chemistry, biochemistry and molecular and cell biology to investigate the mechanisms of DNA repair in higher eukaryotes and the relationship of these processes to carcinogenesis and anti-tumor therapy.

Seeliger, Jessica           PHARM: Membrane biosynthesis, structure & behavior in bacterial pathogenesis

Simmerling, Carlos   BIO 487   T04    Development of tools for efficient simulation of chemical systems and using them to study the structure and dynamics of molecules involved in biological processes.

Tonge, Peter   BIO 487   T64   Biological chemistry and enzymology. Quantitating substrate strain in enzyme-catalyzed reactions using vibrational and NMR spectroscopies. Rational drug design. Pathogenesis of Mycobacterium tuberculosis. Structure-function studies of fluorescent proteins.

Wang, Jin           Theoretical biophysics and biophysical chemistry; protein folding; molecular recognition; biomolecular reaction dynamics; single molecules.

Undergraduate Biology, 107-112 CMM/BLL, Stony Brook University, Stony Brook, NY 11794-5110 - 631 632-8530, 631-632-1680 (fax)

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