Distinguished Professor Emeritus
Department of Biochemistry and Cell Biology
Life Sciences Building
Stony Brook University
Stony Brook, NY 11794-5215
Office telephone: 631-632-8565
Our lab uses the budding yeast, Saccharomyces cerevisiae to identify mutants and characterize genes affecting structure and function of the nucleus. This includes genes encoding proteins involved in gene regulation, DNA replication or chromatin structure. Current effort is focused on: 1) the mechanism of transcriptional silencing of the mating-type loci (i.e., a study of the yeast equivalent of heterochromatin), 2) identification of genes encoding histone acetyltransferases, deacetylases and other histone modifying enzymes, and 3) the role of the conserved KEOPS complex in tRNA modification and other cellular processes.
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