Nadine Pernodet

At the interface between chemistry, physics, materials science and biology, Dr. Nadine Pernodet’s research is based on the effects of surfaces on protein organizations and cell behaviors, relevant to tissue engineering, but also on the effects of nanostructures (drug delivery) to living organisms.
- By controlling surface properties (such as chemistry, topography…) and designing surfaces and patterns, the molecular response relative to protein organization and cellular response are followed in order to explore the structure of protein molecules related to the functioning of a cell, the growth and regeneration of tissue. The control of protein organization gives a powerful tool to reproduce and construct the natural extracellular matrix. By identifying normal extracellular matrix behavior on a surface and determining the importance of protein fibers orientation and mechanics relative to cell functions, my ultimate goal is to be able to reverse (for example, aging process) or ultimately cure some pathologies (such as diabetes, lack of blood clotting), and in direct application for tissue engineering. Biomineralization of proteins is closely associated to protein assembly and organization as well, and is investigated in relation to bone formation.

- Finally, another area of my research is to characterize the impact of nanostructures on cell behavior and functions, to define a safe size range of nanoparticles in order to fully benefit from the nanotechnological advancements and also to specifically target certain types of cells in order to reach efficient drug delivery.