Parker, Kathlyn A

Research Summary – October, 2007 &n= bsp; Kathlyn A. Parker

&= nbsp; &nbs= p; &= nbsp; &nbs= p; &= nbsp; &nbs= p; Professor, Stony Brook University

#80. Pa= rker, Kathlyn A.; Wang, Peng. Deconstruction-= Reconstruction Strategy for Accessing Valuable Polyketides. Preparation of the C15-C24 Stereopentad<= /span> of Discodermolide. Or= ganic Letters ACS= ASAP.

DOI: 10.1021/ol702144u

# 79. Parker, Kathlyn A.; Cao, Huanyan. Scalable, Catal= ytic Asymmetric Synthesis of Syn, Anti Stereotriad Building Blocks for Polypropionate Antibiotics.= Organic Letters (2006), 8(16), 3541-3544.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2006/8/i16/abs/= ol0612612.html

78. Parker, Kathl= yn A.; Wang, Zhongyu. Cleavable Chir= al Auxiliaries in 8p (8p= , 6p= ) El= ectrocyclizations. Organic Letters (2006), 8(16), 3553-3556.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2006/8/i16/abs/= ol061328l.html

77. Parker, Kathlyn A.; Mindt, Thomas L.; Koh<= /span>, Yung-hyo. TESOTf-Induced Rearrangemen= t of Quinols. Efficient Constru= ction of the Fully Functionalized Carbon Skeleton of the Griseu= sins by a Divergent-Reconvergent Approach. Organic Letters (2006), 8(9), 1759-1762.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2006/8/i09/abs/= ol060206q.html

# 76. Lee, Jae Chul; Parker, Kathlyn A.; Sampson, Nicole S. Amino Acid-Bear= ing ROMP Polymers with a Stereoregular Backbone.<= /b>    Journal of the American Chemical Society (2006), 128(14), 4578-4579.

http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/2006/128/i14/= abs/ja058801v.html

# 75. Parker, Kathlyn A.; Fokas, Demosthenes. Enantioselecti= ve Synthesis of (-)-Dihydrocodeinone: A Short Form= al Synthesis of (-)-Morphine.  = Journal of Organic Chemistry (2006), 71(2), 449-455.

http://pubs.acs.org/cgi-bin/abstract.cgi/joceah/2006/71/i02/ab= s/jo0513008.html

# 74. Parker, Kathlyn A.; Chang, Wonsuk. Regioselectivity of Rhodium Nitrene Insertion. Syntheses of Protected Glycals of= L-Daunosamine, D-Saccharosamine, and L-Ristosamine.    Organic Letters (2005), 7(9), 1785-1788.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2005/7/i09/abs/= ol050356l.html

# 73.<= /span> Parker, Kathl= yn A.; Su, Dai-Shi. Models for the synthesis of pluramycin antibiotics. Rearrangement of mono-protected aminogly= cal-substituted cyclohexadienediols.    Journal of Carbohydrat= e Chemistry (2005), 24(2), 199-208.

http://search.epnet.com/login.aspx?direct=3Dtrue&dp=3Daph= &an=3D17678372

# 72.<= /span> Parker, Kathl= yn A.; Su, Dai-Shi. The "reverse polarity" ap= proach to ravidomycin. Aryl C-aminoglycosides from a lithiated= aminoglycal.    Journal of Carbohydrat= e Chemistry (2005), 24(2), 187-197.

http://search.epnet.com/login.aspx?direct=3Dtrue&dp=3Daph= &an=3D17678372

# 71= . Parker, Kathl= yn A.; Lim, Yeon-Hee. The Total Synthesis of (-)-SNF4435 = C and (+)-SNF4435 D.    Journal of the American Chemical Society (2004), 126(49), 15968-15969.

http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/2004/126/i49/= abs/ja044733l.html

70. Parker, Kathl= yn A.; Katsoulis, A. A Strategy for Exploiting the Pseudosymmetry of the C1-C13 Str= etch of Discodermolide.    Organic Letters (2004), 6(9), 1413-1416.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2004/6/i09/abs/= ol049735p.html

# 69= . Parker, Kathl= yn A.; Lim, Yeon-Hee. "Endo" and "Exo" Bi= cyclo[4.2.0]-octadiene Isomers = from the Electrocyclization of Fully Substituted Tetraene Models for SNF 4435C and D. Control of Stereochemistry by Choice of a Functionalized Substitu= ent.    Organic Letters (2004), 6(2), 161-164.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2004/6/i02/abs/= ol036048+.html

68. Parker, Kathl= yn A.; Chang, Wonsuk. A Synthesis of L-Vancosamine Derivatives from Non-Carbohydrate Precursors by a Short Sequence Based on t= he Marshall, McDonald= , and Du Bois Reactions.    Organic Letters= (2003), 5(21),<= span style=3D'mso-spacerun:yes'> 3891-3893.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2003/5/i21/abs/= ol035479p.html

67. Parker, Kathl= yn A.; Mindt, Thomas L. Heterocycle Annulation of Enolizable Vinyl Quinone Imides. Dihydroquinolines and Quinolines from Thermal 6p -Electrocyclizat= ions and Indoles from Photochemical Cyclizations.    Organic Letters (2002), 4(24), 4265-4268.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2002/4/i24/abs/= ol026849x.html

66. Parker, Kathl= yn A.; Mindt, Thomas L. Electrocyclic<= /span> ring closure of the enols of vinyl quinones. A 2H-chromene synthesis= .    Organic Letters (2001), 3(24), 3875-3878.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2001/3/i24/abs/= ol0167199.html

65. Oliver, John S.; Parker, Kathlyn A.; Suggs, J. William. Effect of the U= niversal Base 3-Nitropyrrole on the Selectivity of Neighboring Natural Bases.=     Organic Letters (2001), 3(13), 1977-1980.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2001/3/i13/abs/= ol015966+.html

64. Parker, Kathl= yn A.; Ding, Qing-Jie. A general approach to angucyclines: synthesis of hatomarubigin = A, rubiginone B2, antibiotic X-1488E, 6-hydroxytetrangulol, and tetrangulol.    Te= trahedron (2000), 56(52), 10249-10254.

http://dx.doi.org

Enter 10.1016/S0040-4020(00)00869-3=

63. Parker, Kathl= yn A.; Ding, Qing-Jie. Relative reactivities of amino glycosides and their synthetic equivalents in the C-glycosylation of aromatics= . Synthesis of the pseudo-aglycon (D-C-glycoside) of the benzanthrins.=     Te= trahedron (2000), 56(52), 10255-10261.

http://dx.doi.org

Enter 10.1016/S0040-4020(00)00868-1

62. Parker, Kathl= yn A.; Georges, Asimina T. Reductive Aromatization of Quinols: Synthesis of the C-Aryl= glycoside Nucleus of the Papulacandins and Chaetiacandin.    Organic Letters (2000), 2(4), 497-499.

http://pubs.acs.org/cgi-bin/abstract.cgi/orlef7/2000/2/i04/abs/= ol991346l.html

61. Parker, Kathl= yn A.; Dermatakis, Apostolos<= /span>. Tetrahydroimidazo[1,5,4-ef][1,5]benzodiazepinones<= /span>: Synthesis and Evaluation as HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors.    J= ournal of Organic Chemistry&n= bsp; (1997), 62(12),= 4164-4167.

http://pubs.acs.org/cgi-bin/article.cgi/joceah/1997/62/i12/htm= l/jo962050l.html

60. Parker, Kathl= yn A.; Dermatakis, Apostolos<= /span>. Enantioselective Synthesis of the Enyne A-Ring Synthon of the 1a -Hydroxy Vitamins D.    Journal of Organic Chemistry (1997), 62(19), 6692-6696.

http://pubs.acs.org/cgi-bin/article.cgi/joceah/1997/62/i19/htm= l/jo970957t.html

59. Parker, Kathl= yn A.; Ledeboer, Mark W. Asymmetric Redu= ction. A Convenient Method for the Reduction of Alkynyl Ketones.    Journal of Organic Chemistry (1996), 61(9), 3214-17.

http://pubs.acs.org/cgi-bin/article.cgi/joceah/1996/61/i09/htm= l/jo951712o.html

58. Parker, Kathlyn A.; Su, Dai-Shi. Synthesis of C-= Aryl Furanosides by the "Reverse Polarity" Strat= egy.    Journal of Organic Chemistry (1996), 61(6), 2191-4.

http://pubs.acs.org/cgi-bin/article.cgi/joceah/1996/61/i06/htm= l/jo951344o.html

57. Parker, Kathl= yn A.; Resnick, Lynn. The First Total Synthesis of a Pyripyropene-type ACAT Inhibitor, (± )-GERI-BP001.    Journal of Organic Chemistry (1995), 60(17), 5726-8.

http://pubs3.acs.org/acs/journals/doilookup?in_doi=3D10.1021/jo00122= a074

56. Parker, Kathlyn A.; Coburn, Craig A.; Ko= h, Yung-hyo. Reductive and Nonreductive Aromatization of Quinol Ketal Glycals. Models for the Preparation of C-Aryl Glycoside Natural Produc= ts.    Journal of Organic Chemistry (1995), 60(9), 2938-41.

http://pubs3.acs.org/acs/journals/doilookup?in_doi=3D10.1021/jo00114= a057

# 55= . Parker, Kathl= yn A.; Koh, Yung-hyo.<= span style=3D'mso-spacerun:yes'> Methodology for= the Regiospecific Synthesis of Bis C-Aryl Glycosides. Models for Kidamycins.    Journal of the American Chemical Society (1994), 116(24)= , 11149-50.

http://pubs.acs.org/cgi-bin/archive.cgi/jacsat/1994/116/i24/p= df/ja00103a037.pdf

54. Parker, Kathlyn A.. Novel methods f= or the synthesis of C-aryl glycoside natural products.    Pure and Applied Chemistry (1994), 66(10/11), 2135-8.

http:= //www.iupac.org/publications/pac/1994/pdf/6610x2135.pdf

53. Parker, Kathl= yn A.; Fokas, Demosthenes. The Radical Cyclization Approach to Morphine. Models for Highly Oxygenated Ring-III Synthons.=     Journal of Organic Chemistry (1994), 59(14), 3933-8.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1994/59/i14/pdf= /jo00093a027.pdf

52. Parker, Kathlyn A.; Fokas, Demosthenes. Stereochemistry= of Radical Cyclizations to Side-Chain Olefinic Bonds. An Approach to Control of the C-9 Center of Morphine.    Journal of Organic Chemistry (1994), 59(14), 3927-32.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1994/59/i14/pdf= /jo00093a026.pdf

51. Parker, Kathlyn A.; Fokas, Demosthenes. Convergent synthesis of (± )-dihydroisocodeine in 11 steps by the tandem radical <= span class=3DSpellE>cyclization strategy. A formal total synthesis of (&= plusmn; )-morphine.    Journal of the American Chemical Society (1992), 114(24)= , 9688-9.

http://pubs.acs.org/cgi-bin/archive.cgi/jacsat/1992/114/i24/p= df/ja00050a075.pdf

# 50. Parker, Kathlyn A.; Coburn, Craig A.; Johnson, Paul D.;= Aristoff, Paul. Reductive aromatization of quinols. New convenient= methods for the regiospecific synthesis of p-hydroxy C-aryl glycals.    Journal of Organic Chemistry (1992), 57(20), 5547-50.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1992/57/i20/pdf= /jo00046a049.pdf

49. Parker, Kathl= yn A.; Kim, Ho Jin. A short stereospecific synthesis of (dl)-lycoramine. Control of rel= ative stereochemistry by dipole effects.    Journal of Organic Chemistry (1992), 57(2), 752-5.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1992/57/i02/pdf= /jo00028a066.pdf

48. Parker, Kathl= yn A.; Coburn, Craig A. Regioselectivity in intramolecular nucleophilic aromatic substitution. Synthesis of the potent anti HIV-I 8-halo TIBO analogs.    Journal of Organic Chemistry (1992), 57(1), 97-100.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1992/57/i01/pdf= /jo00027a019.pdf

47. Parker, Kathlyn A.; Coburn, Craig A. Reductive aromatization of quinol ketals: a new synthesis of C-aryl glycosid= es.    Journal of the American Chemical Society (1991), 113(22)= , 8516-18.

http://pubs.acs.org/cgi-bin/archive.cgi/jacsat/1991/113/i22/p= df/ja00022a046.pdf

46. Parker, Kathlyn A.; Coburn, Craig A. A four-step syn= thesis of TIBO R82150.  &nbs= p; Journal of Organic Chemistry (1991), 56(15), 4600-1.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1991/56/i15/pdf= /jo00015a007.pdf

45. Parker, Kathl= yn A.; Coburn, Craig A. A strategy for = the convergent synthesis of gilvocarcins via chromi= um carbene benzannulation. 1-O-Methyldefu= cogilvocarcin V in seven steps.  &n= bsp; Journal of Organic Chemistry (1991), 56(4), 1666-8.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1991/56/i04/pdf= /jo00004a058.pdf

[Erratum to document cited in CA114(9):82308r].    Journal of Organic Chemistry (1992), 57(4), 1318.

44. Parker, Kathlyn A.; Ruder, Suzanne M. Vinylquinone ketals as Diels-Alder dienes. = Construction of functionalized naphthale= nes and nonlinear polycyclic aromatics.    Journal of the American Chemical Society (1989), 111(15)= , 5948-9.

http://pubs.acs.org/cgi-bin/archive.cgi/jacsat/1989/111/i15/p= df/ja00197a069.pdf

43. Parker, Kathl= yn A.; Spero, Denice M= .; Van Epp, James. Radical cyclizations in conformationally= restrained systems. Generation of the cis,cis-hexahydrophenanthro[4,5-bcd]furan tetracycle of morphine.    Journal of Organic Chemistry (1988), 53(19), 4628-30.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1988/53/i19/pdf= /jo00254a053.pdf

42. Parker, Kathl= yn A.; Casteel, Dee Ann. Isoquinoline quinones. Preparation of= saframycin intermediates and a total synthesis of mimosamycin.    Journal of Organic Chemistry (1988), 53(12), 2847-50.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1988/53/i12/pdf= /jo00247a038.pdf

41. Parker, Kathlyn A.; Meschwitz, Su= san M. Short stereoselective synthesis of L-n= ogalose.    Carbohydrate Research (1988), 172(2), 319-26.

http://dx.doi.org

Enter 1= 0.1016/S0008-6215(00)90867-X

40. Parker, Kathlyn A.; Iqbal, Tahir. = New approaches = to the synthesis of vitamin D metabolites.= 2. Effect of some substituents on stereochemistry in the intramolecular cycloadditions of nonatrie= nes.    Journal of Organic Chemistry (1987), 52(19), 4369-77.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1987/52/i19/pdf= /jo00228a040.pdf

39. Parker, Kathl= yn A.. Cyclization approaches to the synthesis of natural products.    Nat. Prod. Chem., Proc. Int. Symp. Pak.-U.S. Binatl. Workshop= , 1st (198= 6), Meeting Date 1984,     307-17.

38. Parker, Kathl= yn A.; Iqbal, Tahir. N,N-Dimethylaniline as a solvent for intramolecular Diels-Alder reactions. Improved yields and changes in stereoisomer ratios.    Tetrahedron Letters (1986), 27(52), 6291-4.

http://dx.doi.org

Enter 1= 0.1016/S0040-4039(00)87789-8

37. Parker, Kathl= yn A.; Koziski, Kathleen A. Directed hydrox= ylation of aromatics.    Journal of Organic Chemistry (1987), 52(4), 674-6.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1987/52/i04/pdf= /jo00380a034.pdf

36.&nbs= p; Parker, Kathlyn A.; Spero, Denice M.; Koziski, Kathleen A. Evaluation of s= ome preparations of trialkoxyphthalic acid derivati= ves.    Journal of Organic Chemistry (1987), 52(2), 183-8.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1986/51/i21/pdf= /jo00371a020.pdf

35. Lawler, Ronald G.; Parker, Kathlyn A.. Efficient disti= llation in the microscale laboratory.    Journal of Chemical Education (1986), 63(11), 1012.

34. Parker, Kathl= yn A.; Farmar, James G. A stereocontro= lled synthesis of dl-biflora-4,10(19),15-triene.<= span style=3D'mso-spacerun:yes'>    Journal of Organic Chemistry (1986), 51(21), 4023-8.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1986/51/i21/pdf= /jo00371a020.pdf

33. Parker, Kathl= yn A.; Breault, Gloria A. Strategies and intermediates for fredericamycin A synthesis= . A 3-substituted 9-alkoxycyclopenta[g]isoquinoline-1,8(2H)-dione. &nbs= p; Tetrahedron Letters (1986), 27(33), 3835-8.

http://dx.doi.org

Enter 1= 0.1016/S0040-4039(00)83892-7

32. Parker, Kathl= yn A.; Spero, Denice M= .; Inman, Karen C. Aryl radical-initiated cyclizations: effect of aryl substituents on ring-size= .    Tetrahedron Letters (1986), 27(25), 2833-6.

http://dx.doi.org

Enter 1= 0.1016/S0040-4039(00)84654-7

31. Parker, Kathl= yn A.; Farmar, James G. Regioselectivi= ty in the Claisen rearrangement of bis-allylic alcohols: electronic and steric effects of C-4 substituen= ts.    Tetrahedron Letters (1985), 26(31), 3655-8.

http://dx.doi.org

Enter 1= 0.1016/S0040-4039(00)89215-1

30. Parker, Kathl= yn A.; Koziski, Kathleen A.; = Breault, Gloria. Synthesis of 2,= 2-disubstituted 4,9-dihydroxy-1H-benz[f]indene-1,3(2H)-diones. = A model sequence for the synthesis of fr= edericamycin.    Tetrahedron Letters (1985), 26(18), 2181-2.

http://dx.doi.org

Enter = 10.1016<= span class=3DMsoHyperlink>/S= 0040-4039(00)98956-1

29. Parker, Kathl= yn A.; Tallman, Elizabeth A. = Annelative phenol synthesis.&nb= sp; Preparation of 7-methyljuglone and 7,9,11= -trideoxydaunomycinone.    Te= trahedron (1984), 40(22), 4781-8.

http://dx.doi.org

Enter 1= 0.1016/S0040-4020(01)91540-6

28. Parker, Kathl= yn A.; Cohen, Isaac D.; Padwa, Albert; Dent, William. Cycloadditions of non-stabilized azomethine ylides and quinones. Synthesis of t= he Reniera isoindole.=     Tetrahedron Letters (1984), 25(43), 4917-20.

http://dx.doi.org

Enter 1= 0.1016/S0040-4039(01)91258-4

27. Parker, Kathl= yn A.; Cohen, Isaac D.; Babine, Robert E.&nbs= p; Approaches to the isoquinoline quinon= e antibiotics. Additions of an amino acid derivative to a quinone monoacetal.    Tetrahedron Letters (1984), 25(33), 3543-6. C

http://dx.doi.org

Enter <= span style=3D'mso-spacerun:yes'> 1= 0.1016/S0040-4039(01)91071-8

26. Parker, Kathl= yn A.; O'Fee, Robert. Halonium-initiated cyclizations of allylic urethanes: stereo- and regioselectivity in functionalizing the olefinic bond.    Journal= of the American Chemical Society (1983), 105(3), 654-5.

http://pubs.acs.org/cgi-bin/archive.cgi/jacsat/1983/105/i03/p= df/ja00341a073.pdf

25. Parker, Kathl= yn A.; Babine, Robert E. Revision of ass= ignment of structure to the pyrrolodiazepinone antitumor antibiotic sibiromycin= .    Journal of the American Chemical Society (1982), 104(25)= , 7330-1.

http://pubs.acs.org/cgi-bin/archive.cgi/jacsat/1982/104/i25/p= df/ja00389a079.pdf

24. Parker, Kathl= yn A.; O'Fee, Robert P. Amidopalladation of tertiary allylic amines and of terminal olefins with phthalimide and N-methyltoluenesulfonamide.    Journal of Organic Chemistry (1983), 48(9), 1547-50.

http://pubs.acs.org/cgi-bin/archive.cgi/joceah/1983/48/i09/pdf= /jo00157a037.pdf

23. Parker, Kathl= yn A.; Babine, Robert E. Revision of the assignment of relat= ive stereochemistry in sibirosamine: synthesis of m= ethyl N-toluenesulfonyl-a= -D-sibirosaminopyranoside.    Tetrahedron Letters (1982), 23(17), 1763-6.