Info for Students and Course of Study
The two institutions participating in the Biochemistry and Structural Biology Program—Stony Brook University and Brookhaven National Laboratory—each have world-class facilities for modern biochemical and structural research.
At Stony Brook University
There are a number of core facilities that support and enhance the research productivity of investigators at Stony Brook. These include the Center for Analysis and Sequencing of Macromolecules (CASM); a DNA sequencing facility; a mass spectrometer facility; the University Microscopy Imaging Center (UMIC), with high-resolution equipment for performing light, confocal microscopy, and transmission/scanning electron microscopy; numerous shared computer facilities; a transgenic mouse facility; a spacious and expertly operated animal research laboratory; a monoclonal antibody tissue culture center; and a microarray facility.
An important facility at Stony Brook is the Center for Structural Biology (CSB). The CSB is housed on the first and ground floors of the Centers for Molecular Medicine. The research activities of the CSB revolve around three major biophysical approaches for studying the structure and dynamics of complex biological macromolecules: NMR spectroscopy, X-ray crystallography, and computer simulation. In addition, research laboratories in the CSB are well equipped with biophysical instrumentation for Fourier transform infrared, fluorescence, and circular dichroism spectroscopy, as well as atomic force microscopy. The Keck NMR Center for Structural Biology houses three NMR spectrometers: a standard bore 700 MHz spectrometer for solution NMR studies and wide bore 500 MHz and 600 MHz spectrometers for solid-state NMR studies. The X-ray facility is equipped with two RU-H3R X-ray generators and two R-Axis IV++ imaging plate detectors. In addition to this in-house facility, X-ray crystallographers at Stony Brook have access to beamline X26C at Brookhaven National Laboratory. The CSB computational facility is comprised of graphics workstations linked to two multiprocessor servers: the Seawulf Cluster is a custom-built 470-processor Linux Cluster and the Blue Gene supercomputer at BNL. All students have their own computer accounts with access to campus e-mail, electronic journals, and Web services.
At Brookhaven National Laboratory
Brookhaven National Laboratory (BNL) has world-class facilities for structural biology that are available to students in the BSB Program. The National Synchrotron Light Source (NSLS) at BNL has high-energy beamlines for X-ray crystallography, as well as for UV, CD, and IR spectroscopy. An important aspect of inter-institutional cooperation is a dedicated beamline (X26C) at the NSLS that is shared by Stony Brook, BNL, and Cold Spring Harbor Laboratory. This dedicated line greatly facilitates structural biology at all three institutions. Other facilities include a Scanning Transmission Electron Microscope (STEM) in the Department of Biology. For high-level computational applications, Stony Brook University has access to a IBM Blue Gene/L massively parallel supercomputer located at BNL. It is the centerpiece of the New York Center for Computational Sciences (NYCCS), a cooperative effort between BNL and Stony Brook University. Each of the 18 racks consists of 1024 compute nodes (a total of 18432 nodes) with each node containing two 700 MHz PowerPC 440 core processors and 1 GB of memory (a total of 36864 processors and 18.4 TB of memory).
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