Aaron Neiman, Ph.D.
Department of Biochemistry and Cell Biology
Life Sciences Building
Stony Brook University
Stony Brook, NY 11794-5215
Office telephone: 631-632-1543
Lab telephone: 631-632-1421
In response to starvation, diploid cells of the baker’s yeast
Saccharomyces cerevisiae differentiate into haploid spores. The process of
spore formation involves a form of cell division in which the four daughter
nuclei produced by meiosis are encapsulated within newly formed plasma membranes
termed prospore membranes. Subsequent to the closure of the prospore membrane,
a complex coat called a spore wall is formed around each spore, which provides
the spore with resistance to environmental stresses. Our lab is studying the
molecular mechanisms underlying both the formation and growth of the prospore
membrane as well as the assembly of the spore wall. These studies take us into
a variety of areas of cell biology including vesicle trafficking, membrane
fusion, cytokinesis, signal transduction, and extracellular matrix assembly.
spore formation: Blue indicates
the plasma membrane, red the nuclear envelope, and green the prospore
membrane. The black “T”s
on the periphery of the nucleus indicate the spindle poles and the thick
gray represents the spore wall.
Top of Page