Department of Biochemistry
and Cell Biology |
| Paul M. Bingham
|
Genetic control of development and gene expression in
animals |
| Deborah Brown |
Cholesterol/sphingolipid-rich domains in membrane signaling |
| Kevin Czaplinski |
Post-transcriptional control of gene expression in the nervous system |
| Vitaly Citovsky |
Nuclear targeting and intercellular communication in plants |
| Neta Dean |
Glycosylation; fungal pathogenesis |
| Dale G. Deutsch |
Marijuana; molecular neurobiology of anandamide |
| J. Peter Gergen |
Gene expression and development in Drosophila |
Steven Glynn |
Structure and mechanism of protein-unfolding machines in mitochondria |
| Robert Haltiwanger |
Glycobiology; biosynthesis, structure, and function |
| Bernadette C. Holdener |
Genetic regulation of early mammalian development |
| Nancy Hollingsworth |
Meiotic synapsis, recombination, and segregation in yeast |
| Wali
Karzai |
Structure and function of RNA-binding proteins and biochemical studies
of the SmpB•tmRNA quality control system |
| William J. Lennarz |
Biosynthesis and function of glycoproteins in cell-cell
interactions |
| Huilin Li |
Structure and function of large protein machines |
| Erwin London |
Membrane protein structure/translocation/folding |
| Ed Luk |
Chromosome biology and genome regulation |
| Harvard Lyman |
Photocontrol of chloroplast development |
| Kenneth B. Marcu |
Antibody class switch mechanism; NFkB kinases; Myc gene
control |
| Benjamin Martin |
Stem cell maintenance and differentiation, Developmental mechanisms of cancer pathogenesis |
| Aaron Neiman |
Vesicle trafficking and membrane/cytoskeletal interactions |
| Nisson Schechter |
Homeobox and filament proteins in neuronal differentiation |
| Sanford Simon |
Extracellular degradation by neutrophil proteases |
| Steven Smith |
Structure and function of membrane proteins |
| Rolf Sternglanz |
Chromatin structure and function; gene expression; HATs |
| Gerald H. Thomsen |
Growth factors /signal transduction in early vertebrate
development |
| |
Department of Chemistry |
| Elizabeth Boon |
Nitric oxide regulation of quorum sensing and biofilm formation in bacteria |
| Isaac Carrico |
Site-specific protein labeling; glycoproteins. |
| Carlos Simmerling |
Development of tools for efficient and simulation of chemical systems and using them to study the structure and dynamics of molecules involved in biological processes. |
| Peter Tonge |
Spectroscopic insights into enzyme mechanisms and structure |
| |
|
Department of Medicine |
| Jian Cao, M.D. |
Biology and prevention of cancer metastasis |
| Wen-Tien Chen |
Proteases / integrins in cancer invasion, metastasis,
angiogenesis |
| Berhane Ghebrehiwet |
Biochemistry; function of the complement system |
| Ian Hitchcock |
|
| Yaacov Hod |
Hormonal control of gene expression; mRNA turnover |
| Yusaf Hannun |
Bioactive lipids in cancer pathogenesis and therapeutics |
| Richard Lin |
Kinase signaling and cell proliferation |
| Cungui Mao |
Bioactive sphingolipids in cell growth, differentiation, apoptosis, and autophagy |
| Lina M. Obeid |
Bioactive lipids in Inflammation, Aging and Cancer |
| Mario Rebecchi |
Phospholipases and signal transduction |
| Roy Steigbigel |
Immune dysfunction induced by HIV infection |
| William Van Nostrand |
Vascular functions of Alzheimer's disease amyloid beta-protein |
| |
Department of Molecular Genetics & Microbiology |
Jorge Benach
|
Pathogenesis of spirochetal infections and their host
responses |
| Nicolas Carpino |
Positive and Negative Regulation of T cell Receptor Signaling |
| Bruce Futcher |
Cell cycle, cyclins, and yeast genetics |
| Michael Hayman |
Viral/cellular oncogenes; differentiation of erythroid
cells |
| Patrick Hearing |
Adenovirus regulation of cellular proliferation and
gene expression; adenovirus vectors for human gene therapy |
| James Konopka |
Signal transduction, morphogenesis and genetics of pathogenic fungi |
| Laurie Krug |
Herpesviruses establish a life-long infection in their hosts. This chronic infection at the host level is comprised of both lytic (productive) and latent (quiescent) phases. Lytic replication leads to infectious particle production and is essential for dissemination and transmission. Latency is characterized by the maintenance of the viral genome with a restricted gene expression program in long-lived host cells. The latent program of gammaherpesviruses Epstein-Barr Virus (EBV) and Kaposi’s sarcoma associated-herpesvirus (KSHV) in cellular reservoirs is associated with lymphomas and neoplasms. My research interests lie in understanding the molecular determinants of virus-host interactions during chronic gammaherpesvirus infections using a mouse model pathogen. |
| Janet Leatherwood |
Cell cycle control and DNA replication in fission yeast |
| Erich R. Mackow |
Viral Pathogenesis, Regulation of Innate Immunity, Hantavirus, Dengue Virus and Rotavirus Regulation of Cell Signaling Responses, miRNAs and Endothelial cell functions. |
| Nancy Reich |
Cytokine and Innate Immune Responses |
| David Thanassi |
Secretion of virulence factors by bacterial pathogens;
pilus biogenesis by uropathogenic Escherichia coli |
| Eckard Wimmer |
RNA virus genetics, replication, pathogenicity, cellular
receptors |
| Wei-Xing Zong |
Molecular regulation of apoptotic and necrotic cell death. |
| |
Department of Neurobiology
and Behavior |
| Simon Halegoua |
Molecular control of the neuronal phenotype |
| Maurice Kernan |
Molecular basis of mechanical senses |
| Joel Levine |
Cell-surface molecules of the developing nervous system |
| David McKinnon |
Molecular physiology of sympathetic neurons and cardiac
muscle |
| Howard Sirotkin |
Genetic and molecular analysis of early vertebrate
development |
| Lonnie Wollmuth |
Molecular mechanisms of synaptic transmission |
| |
Department of Oral Biology
and Pathology |
| Soosan Ghazizadeh |
Epithelial stem cell biology; Skin bioengineering and gene therapy. |
| |
Department of Pathology |
| Jiang Chen |
Skin and hair follicle development, maintenance and malignancy |
| Howard B. Fleit |
Leukocyte Fc receptors; macrophage differentiation |
| Martha Furie |
Our laboratory studies the role of inflammation in defending against bacterial infections, with emphasis on recruitment of protective leukocytes by the vascular endothelium. Bacteria under investigation include Borrelia burgdorferi, the agent of Lyme disease, and Francisella tularensis, a potential bioweapon. |
| Jingfang Ju |
Post-transcriptional control of non-coding RNAs and RNA binding proteins in cancer |
| Richard R. Kew |
Leukocyte chemotaxis/inflammation |
| Toni Koller |
|
| Ute Moll |
Tumor suppressor genes; mechanism of p53 inactivation |
| Kenneth Shroyer |
Cancer biomarkers as diagnostic adjuncts in cervical pathology and cytopathology; cervical cancer and HPV |
| Eric Spitzer |
Molecular biology of Cryptococcus neoformans |
| Gary Zieve |
Assembly/transport of snRNP particles |
| |
Department of Pharmacological
Sciences |
| Miguel Berrios |
Cell structure and function; the cell biology of DNA damage and repair. |
| Daniel Bogenhagen |
Mitochondrial DNA; DNA repair |
| Emily Chen |
Breast Cancer Metastasis & Shotgun Proteomics |
| Holly Colognato |
Extracellular matrix in the brain; roles during development and during neurodegeneration. |
| Michael A. Frohman |
Our lab explores roles for lipid signaling pathways in cellular and physiological settings. More specifically, we focus on functions mediated by members of the Phospholipase D (PLD), PI4P Kinase, and Lipin enzyme families. Areas of interest include: Mitochondrial fusion & fission and the ability of mitochondria to serve as scaffolds for biogenesis of a specialized form of RNAi known as piRNA; and Subcellular trafficking of membrane vesicles during signaling-activated exocytosis and endocytosis. Disease-related topics include fertility (spermatogenesis), neurodegeneration, diabetes, pathological thrombus formation, cancer, and impaired immune responses. |
| Miguel Garcia-Diaz |
Deficiencies in mitochondrial gene expression cause multiple human pathologies. Our lab combines structural, genetic and biochemical studies to understand the mechanism and function of proteins that are key for mitochondrial protein production, and investigate how the alteration of different gene expression processes can result in mitochondrial disfuction and disease. |
| Arthur Grollman |
Mechanisms of chemical mutagenesis/carcinogenesis |
| Craig C. Malbon |
Heterotrimetric G-proteins in development and cancer |
| Masaaki Moriya |
Cellular responses to DNA damage. |
| Joav Prives |
Cytoskeletal membrane interactions in muscle cells |
| Jessica C. Seeliger |
We are applying biochemical, microbiological and biophysical methods to fundamental questions in bacterial membrane biogenesis as they relate to Mycobacterium tuberculosis, the bacterium that causes tuberculosis, and to bacterial pathogenesis in general: How is lipid biosynthesis accomplished at the cytosol-membrane interface? What are the molecular mechanisms underlying bacterial membrane assembly? How can we subvert lipid biosynthesis and membrane assembly pathways for antimicrobial therapy? |
| Markus Seeliger |
Mechanism of Protein kinases and Ubiquitin Ligases in Cancer and Aging |
| Orlando Schärer |
Chemical Biology of DNA damage and repair. |
| Ken-Ichi Takemaru |
Wnt Signaling in Development and Disease |
| Styliani-Anna Tsirka |
Neuronal-microglial interactions in the central nervous
system |
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Department of Physiology and
Biophysics |
| Mark Bowen |
Single molecule spectroscopy; Coordination of post-synaptic glutamate receptor signaling by the MAGUK family of scaffolds |
| W. Todd Miller |
Tyrosine phosphorylation and signal transduction |
| Suzanne Scarlata |
Cell signaling through heterotrimeric G proteins |
| Ilan Spector |
Neuronal differentiation and microfilaments |
| Hsien-yu Wang |
Wnt signaling pathways conserved from fly to human control early development. Abnormal activation of Wnt pathway induces cancer. Our research focuses on (1) regulation of cell signaling stimulated by Wnt at molecular level; (2) differentiation of embryonic stem cell modulated by Wnt signaling. |
| Thomas White |
Molecular biology and physiology of gap junction channels |
| |
Brookhaven National Laboratory |
| Richard Setlow |
DNA damage and repair; carcinogenesis in fish |
| F. William Studier |
Phage T7 replication; large-scale nucleotide sequencing |
| |
Cold Spring Harbor Laboratory |
| Gregory Hannon |
Growth control in mammalian cells; post-transcriptional gene silencing |
| Leemor Joshua-Tor |
Structural biology; nucleic acid regulation; RNAi; molecular recognition; X-ray crystallography |
| Adrian Krainer |
mRNA splicing; gene expression; RNA-protein interaction |
| Robert Martienssen |
Plant genetics; transposons; development; gene regulation; DNA methylation |
| Alea Mills |
Cancer; development; aging; senescence; epigenetics |
| Scott Powers |
Cancer gene discovery; cancer diagnostics and therapeutics; cancer biology |
| David L. Spector |
Spatial organization of gene expression |
| Arne Stenlund |
DNA replication of papillomaviruses |
| Bruce Stillman |
DNA replication and chromatin assembly in human and yeast
cells |
| Nicholas K. Tonks |
Characterization of protein tyrosine phosphatases |
| Christopher Vakoc |
Chromatin; epigenetics; acute myeloid leukemia; self-renewal; RNAi screening; mouse models of cancer |
| Linda Van
Aelst |
Signal transduction; Ras and Rac proteins, tumorigenesis |
| Michael H. Wigler |
Growth control in yeast and mammalian cells |
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