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Faculty

Ed Luk Ph.D
Assistant Professor
Department of Biochemistry and Cell Biology

 

Selected Publications


Luk, E., Ranjan, A., FitzGerald, P.C., Mizuguchi, G., Huang, Y., Wei, D., and Wu, C. (2010) Stepwise histone replacement by SWR1 requires dual activation with histone H2A.Z and canonical nucleosome. Cell. 143, 725-736.

Wu, W.H., Wu, C.H., Ladurner, A., Mizuguchi, G., Wei, D., Xiao, H., Luk, E., Ranjan, A., and Wu, C. (2009) N-terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex. J Biol Chem. 284, 6200-6207.

Zhou, Z., Feng, H., Hansen, F.D., Kato, H., Luk, E., Freedberg, D.I., Kay, L.E., Wu, C., Bai, Y. (2008) NMR structure and function of chaperone Chz1 complexed with histones H2A.Z-H2B. Nat Struct Mol Biol. 15, 868-869.

Luk, E., Vu, N.D., Patteson, K., Mizuguchi, G., Wu, W.H., Ranjan, A., Backus, J., Sen, S., Lewis, M., Bai, Y. and Wu, C. (2007) Chz1, a chaperone for histone H2AZ. Mol Cell. 25, 357-368.

Wu, W.H., Alami, S., Luk, E., Wu, C.H., Sen, S., Mizuguchi, G., Wei, D. and Wu, C. (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol. 12, 1064-1071.

Luk, E., Yang, M., Jensen, L.T., Bourbonnais, Y. and Culotta, V.C. (2005) Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae. J Biol Chem. 280, 22715-22720.

Luk, E., Carroll, M., Baker, M., and Culotta, V.C. (2003) Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a novel member of the mitochondrial carrier family. Proc Natl Acad Sci U S A. 100, 10353-10357.

Luk, E., Jensen, L. and Culotta, V.C. (2003) The many highways for intracellular trafficking of metals. J Biol Inorg Chem. 8, 803-809.

Field, L.S., Luk, E. and Culotta, V.C. (2002) Copper chaperones: personal escorts for metal ions. J Bioenerg Biomembr. 34, 373-379.

Luk, E. and Culotta, V.C. (2001) Manganese superoxide dismutase in Saccharomyces cerevisiae acquires its metal co-factor through a pathway involving the Nramp metal transporter, Smf2p. J Biol Chem. 276, 47556-47562.


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