Ed Luk Ph.D
Assistant Professor
Department of Biochemistry and Cell Biology |
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Selected Publications |
Luk, E., Ranjan, A., FitzGerald, P.C., Mizuguchi, G., Huang, Y., Wei, D., and Wu, C. (2010) Stepwise histone replacement by SWR1 requires dual activation with histone H2A.Z and canonical nucleosome. Cell. 143, 725-736.
Wu, W.H., Wu, C.H., Ladurner, A., Mizuguchi, G., Wei, D., Xiao, H., Luk, E., Ranjan, A., and Wu, C. (2009) N-terminus of Swr1 binds to histone H2AZ and provides a platform for subunit assembly in the chromatin remodeling complex. J Biol Chem. 284, 6200-6207.
Zhou, Z., Feng, H., Hansen, F.D., Kato, H., Luk, E., Freedberg, D.I., Kay, L.E., Wu, C., Bai, Y. (2008) NMR structure and function of chaperone Chz1 complexed with histones H2A.Z-H2B. Nat Struct Mol Biol. 15, 868-869.
Luk, E., Vu, N.D., Patteson, K., Mizuguchi, G., Wu, W.H., Ranjan, A., Backus, J., Sen, S., Lewis, M., Bai, Y. and Wu, C. (2007) Chz1, a chaperone for histone H2AZ. Mol Cell. 25, 357-368.
Wu, W.H., Alami, S., Luk, E., Wu, C.H., Sen, S., Mizuguchi, G., Wei, D. and Wu, C. (2005) Swc2 is a widely conserved H2AZ-binding module essential for ATP-dependent histone exchange. Nat Struct Mol Biol. 12, 1064-1071.
Luk, E., Yang, M., Jensen, L.T., Bourbonnais, Y. and Culotta, V.C. (2005) Manganese activation of superoxide dismutase 2 in the mitochondria of Saccharomyces cerevisiae. J Biol Chem. 280, 22715-22720.
Luk, E., Carroll, M., Baker, M., and Culotta, V.C. (2003) Manganese activation of superoxide dismutase 2 in Saccharomyces cerevisiae requires MTM1, a novel member of the mitochondrial carrier family. Proc Natl Acad Sci U S A. 100, 10353-10357.
Luk, E., Jensen, L. and Culotta, V.C. (2003) The many highways for intracellular trafficking of metals. J Biol Inorg Chem. 8, 803-809.
Field, L.S., Luk, E. and Culotta, V.C. (2002) Copper chaperones: personal escorts for metal ions. J Bioenerg Biomembr. 34, 373-379.
Luk, E. and Culotta, V.C. (2001) Manganese superoxide dismutase in Saccharomyces cerevisiae acquires its metal co-factor through a pathway involving the Nramp metal transporter, Smf2p. J Biol Chem. 276, 47556-47562.
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