Wali Karzai, Ph. D. Associate Professor of Biochemistry Department of Biochemistry and Cell Biology And Center for Infectious Diseases Stony Brook University Phone: (631) 632-1688 Fax: (631) 632-8575 E-mail: a.karzai@ms.cc.sunysb.edu
	Wali Karzai is a PEW SCHOLAR.
Research Interests

Post-transcriptional Regulation of Gene Expression

Post-transcriptional processing events play a crucial role in controlling gene expression. Our research is aimed at elucidating post-transcriptional gene regulatory processes in prokaryotes. We are particularly interested in investigating: 1) Molecular mechanisms that govern translation quality control; 2) Molecular basis for nonstop mRNA decay; 3) The mechanisms by which RNases and small non-coding RNAs (ncRNAs) regulate gene expression and RNA stability; 4) Biochemical mechanism of targeted proteolysis and the role of AAA+ proteases in bacterial pathogenesis; 5) Discovery of novel antibiotics and vaccines.

Our Approach

We use a combination of protein biochemistry, molecular genetics, functional genomics, bioinformatics, and structural approaches to determine the biological function and mechanism of action of RNA-protein complexes that participate in regulation of gene expression.

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